196 patents
Page 2 of 10
Utility
Coaxial introduction of calibrant in a flow path with analyte to an ion source
19 Sep 23
Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS).
Michael O. Fogwill, Joseph D. Michienzi, Sylvain Gilles Cormier
Filed: 14 Apr 21
Utility
RPLC-based peptide mapping chromatographic performance using metal chelators as mobile phase additives
19 Sep 23
The present technology relates to a method of analyzing a sample including an analyte.
Robert Birdsall, Ying Qing Yu, Jacob Kellett
Filed: 5 Jun 20
Utility
Methods for liquid chromatography calibration for rapid labeled N-glycans
5 Sep 23
Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography.
Michael F. Morris, Matthew A. Lauber, Darryl W. Brousmiche
Filed: 25 Oct 19
Utility
Fluidic configuration for a multidimensional liquid chromatography system
5 Sep 23
Multidimensional liquid chromatography (MDLC) systems include valve configurations that enable a flow containing analytes in the eluent of a first dimension liquid chromatography system to be modulated such that the analytes can be captured in fluidic loops and subsequently provided to a second dimension liquid chromatography system.
Michael O. Fogwill, Sylvain Gilles Cormier, Thomas Swann, Francis Patrick Tracey
Filed: 4 May 21
Utility
Methods of use for low-bind polypropylene plates and vials
5 Sep 23
The present disclosure relates to a method of analyzing a sample comprising a hydrophobic molecule.
Moon Chul Jung, Mary Elizabeth Lame, Caitlin Dunning, Christopher John Hughes, Xiaoxiao Liu, Paula Orens, Yun Wang Alelyunas, Erin E. Chambers, David Dao, Robert Birdsall
Filed: 3 Mar 20
Utility
Matching thermally modulated variable restrictors to chromatography separation columns
22 Aug 23
Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column.
Michael O. Fogwill, Joseph D. Michienzi, Geoff Gerhardt, James P. Murphy
Filed: 30 Jun 20
Utility
Variable fluidic restrictor having selective restriction
8 Aug 23
A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided.
Zongren Shang, Stanislaw Koziol, Joseph D. Michienzi, Michael Eggertson, Keith Fadgen
Filed: 8 Apr 22
Utility
Rotor for rheological measurements of material with variable volume
8 Aug 23
A rheological system includes a sample chamber, a compressed air system configured to provide compressed air to pressurize the sample chamber, and a rotor configured for rheological measurement of a material with variable volume, the rotor including an elongated shaft extending to a measurement portion having a widened geometry relative to the elongated shaft.
Reginald Lee, Amit Ahuja, Sally Childears
Filed: 8 Oct 20
Utility
Method and apparatus for high pressure sealing
25 Jul 23
The present technology generally relates to devices, systems and methods for providing robust sealing between surfaces in a pressurized system, such as a chromatography system.
Emily J. Berg, Joshua A. Shreve
Filed: 13 May 20
Utility
Method for determining a dwell volume of a chromatographic system
25 Jul 23
Described is a method for determining a dwell volume of a liquid chromatography system and a liquid chromatography system that can determined the system dwell volume.
Jason F. Hill, Martin Gilar, Abhijit Tarafder, Christopher DesJardins
Filed: 19 Aug 20
Utility
Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes
25 Jul 23
Matthew A. Lauber, Mathew H. DeLano, Scott A. McCall, Jonathan L. Belanger, Theodore A. Dourdeville, Kerri M. Smith, Paul D. Rainville, Dimple D. Shah, Stephen J. Shiner, Catalin Doneanu, Michael Donegan
Filed: 17 Sep 18
Utility
Use of vapor deposition coated flow paths for improved analytical analysis
25 Jul 23
Xiaoxiao Liu, Anna Boardman, Mathew H. DeLano, Matthew A. Lauber
Filed: 17 Jan 20
Utility
Rheometer having resistance heater and cooling device
4 Jul 23
Described are a method and device for controlling a temperature of a sample.
Scott Merrullo, Nigel Doe, Peter Foster
Filed: 21 May 21
Utility
Multi-injection mode valve module
23 May 23
A chromatography system includes a gradient delay volume defined as an overall fluid volume between where gradient is proportioned until an inlet of a chromatography column, a pump pumping a flow of gradient; and at least one valve located downstream from the pump, the at least one valve having a plurality of ports including an inlet port that receives the flow of gradient from the pump and an outlet port through which the flow of gradient exits the at least one valve, the at least one valve having at least two positions.
Sylvain Cormier, Richard W. Andrews, Peyton C. Beals
Filed: 19 Mar 21
Utility
Link chain, chain system and method
23 May 23
Described is a chain including a plurality of links pivotally connected to each other such that the chain is configured to bend in one direction without back-bending.
Jeffrey Musacchio
Filed: 28 Jul 20
Utility
Determination of dynamic parameters for adaptive actuator control
16 May 23
An actuator control system, mechanical testing system, and method for adaptive control of an actuator of a mechanical testing device is provided.
Kevin Alstrin
Filed: 25 Aug 21
Utility
Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material
9 May 23
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials.
Nicole L. Lawrence, Kevin Daniel Wyndham, Beatrice W. Muriithi
Filed: 6 Mar 17
Utility
Chromatographic dimension selection in multidimensional liquid chromatography
11 Apr 23
A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dimension, a second dimension column path configured to perform a separation process in a second dimension that is different than the first dimension, a valve system; and a sample injection system fluidically connected to the valve system.
Michael O. Fogwill
Filed: 28 Jun 21
Utility
Methods, compositions and kits useful for pH gradient cation exchange chromatography
28 Mar 23
The present disclosure relates to methods, compositions and kits useful for the enhanced pH gradient cation exchange chromatography of a variety of analytes.
Qi Wang, Matthew A. Lauber
Filed: 8 May 19
Utility
Solid phase extraction methods for enhanced removal of phospholipids from biological samples
14 Mar 23
In various aspects, the present disclosure pertains to methods of performing a sample enrichment procedure, which comprise: adding a sample fluid that comprises at least one phospholipid and at least one target analyte to a sorbent that comprises a hydrophobic component and a cation exchange component, thereby resulting in sorbent with bound phospholipid and bound target analyte; adding an aqueous solution comprising an acidic compound and a salt; adding an organic solution to the sorbent thereby desorbing at least a portion of the bound phospholipid from the sorbent; and adding an elution solution to the sorbent, thereby desorbing at least a portion of the bound target analyte from the sorbent and forming a solution of the target analyte in the elution solution.
Bonnie A. Alden, Kenneth Berthelette, Jon Finch, Donna Osterman, Thomas Swann, Thomas H. Walter
Filed: 21 Dec 18