196 patents
Page 4 of 10
Utility
High sample throughput differential scanning calorimeter
18 Oct 22
Described is a differential scanning calorimeter (DSC) instrument capable of performing analyses of multiple samples at the same time.
Donald J. Russell, David Serrell, Anthony E. Arnerich
Filed: 10 Oct 19
Utility
Method of using chemical tags to improve the identification, quantification and spatial localization of components in a sample
4 Oct 22
The present disclosure relates to a method for using chemical tags which have two or more sites for ionization to improve quantification and identification of components of interest from a complex mixture.
Giuseppe Astarita, Darryl W. Brousmiche
Filed: 17 Feb 17
Utility
Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
20 Sep 22
Reagents comprising MS active, fluorescent molecules with an activated functionality for reaction with amines useful in tagging biomolecules such as N-glycans and uses thereof are taught and described.
Darryl W. Brousmiche, Ying-Qing Yu, Matthew Lauber
Filed: 5 Sep 19
Utility
Hybrid material for chromatographic separations comprising a superficially porous core and a surrounding material
13 Sep 22
The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for their preparation and separations devices containing the chromatographic materials.
Nicole L. Lawrence, Beatrice W. Muriithi, Kevin D Wyndham
Filed: 6 Mar 17
Utility
Difluoroacetic acid ion pairing reagent for high sensitivity, high resolution LC-MS of biomolecules
6 Sep 22
The present disclosure relates to the determination of analytes in a sample using chromatography.
Matthew A. Lauber, Jennifer M. Nguyen, Ximo Zhang, Nilini Ranbaduge, Robert Birdsall, Henry Shion
Filed: 28 Jan 19
Utility
Immobilized enzymatic reactor
6 Sep 22
An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi.
Joomi Ahn, Moon Chul Jung, Kevin D. Wyndham
Filed: 16 Dec 19
Utility
Composite materials containing nanoparticles and their use in chromatography
30 Aug 22
Novel porous materials comprising nanoparticles, use in chromatographic separations, processes for its preparation, and separations devices containing the chromatographic material are described by the instant invention.
Kevin D. Wyndham, Nicole L. Lawrence
Filed: 1 Feb 16
Utility
Establishing fluidic connections between chromatography components
30 Aug 22
A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly.
Peter Kirby, Marcos O. Peroza, Steven D. Trudeau, Ryan Hill, Raymond P. Fisk, Jonathan Belanger, Wade P. Leveille
Filed: 17 May 19
Utility
Affinity resins and sample preparation devices based on cartilaginous fish IgNAR derived binding domains
16 Aug 22
The present disclosure relates to protein arrays and methods of using the same for the detection, quantification and characterization of biomolecules that specifically bind to the array among various other biomolecules in a biological sample.
Matthew A. Lauber, Xiaoxiao Liu, Beatrice Muriithi, Edouard S. P. Bouvier
Filed: 11 Aug 20
Utility
Mobile phase controller for supercritical fluid chromatography systems
2 Aug 22
The present disclosure relates to an apparatus for regulating the average mobile phase density or pressure in a carbon dioxide based separation system.
Joshua A. Shreve
Filed: 26 Aug 19
Utility
Chromatographic filter
19 Jul 22
The invention provides filters and methods of assembling filters.
Mathew H. Delano, Jonathan Belanger, Raymond P. Fisk
Filed: 6 Jun 14
Utility
Liquid chromatography/mass spectrometry methods for the analysis of polar molecules
19 Jul 22
A mixed-mode chromatography method for the determination of phosphorylated sugars in a sample is provided.
Paul D. Rainville, Kerri M. Smith
Filed: 25 Jul 19
Utility
Sorbent particles for sample treatment
5 Jul 22
Sorbents, devices, kits and methods useful for sample treatment are disclosed herein.
Darryl W. Brousmiche, Kevin D. Wyndham, Nicole L. Lawrence, Jacob N. Fairchild, Bonnie A. Alden
Filed: 2 Oct 19
Utility
System and method for controlling fluid flow within a chromatography system
5 Jul 22
The present disclosure relates to methodologies, systems, apparatus, and kits for controlling fluid flow within a chromatography system.
Michael O. Fogwill, Thomas S. McDonald, Joshua A. Shreve
Filed: 29 May 19
Utility
Interface module for two-dimensional liquid chromatography
14 Jun 22
Described are an interface module for two-dimensional chromatography and a method of performing a chromatographic separation that may use the interface module.
Sylvain Gilles Cormier, Charles H. Phoebe, Jr.
Filed: 30 Aug 19
Utility
Techniques for accelerating thermal equilibrium in a chromatographic column
7 Jun 22
Techniques are described for accelerating thermal equilibrium in a chromatographic column.
Edouard S. P. Bouvier, Joseph Kareh
Filed: 8 Oct 19
Utility
Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
7 Jun 22
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 25 Jan 16
Utility
Methods of enhancing MS detection of tagged glycans
7 Jun 22
Methods for derivatization of biomolecules including glycans or other biopolymers with one or more fluorescent, MS active compounds by reductive amination or rapid tagging in order to produce derivatized glycan having a pKa>7 and between about 200 Å2 and about 1000 Å2 of nonpolar surface area are described.
Darryl W. Brousmiche, Matthew A. Lauber
Filed: 19 Jun 17
Utility
Mechanisms and methods for liquid sample introduction into a chromatography system
24 May 22
The disclosure relates to a system for liquid sample introduction into a chromatography system.
Jason Hill, Abhijit Tarafder, Joshua Burnett, Michael O. Fogwill
Filed: 8 Nov 19
Utility
System and method for controlling fluid flow within a liquid chromatography system
24 May 22
The present disclosure relates to methodologies, systems, and apparatus for controlling fluid flow within a chromatography system.
Michael O. Fogwill, Theodore A. Dourdeville
Filed: 29 May 19