13 patents
Utility
ST-246 (tecovirimat monohydrate) suspension formulations
10 Oct 23
The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone.
Shanthakumar R. Tyavanagimatt, Kris Holt, Ying Tan, Melialani A. C. L. S. Anderson, Dennis E. Hruby
Filed: 14 Jul 22
Utility
ST-246 (tecovirimat monohydrate) SUSPENSION FORMULATIONS
19 Jan 23
The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone.
Shanthakumar R. TYAVANAGIMATT, Kris HOLT, Ying TAN, Melialani A.C.L.S. ANDERSON, Dennis E. HRUBY
Filed: 14 Jul 22
Utility
ST-246 (tecovirimat monohydrate) suspension formulations
6 Sep 22
The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone.
Shanthakumar R. Tyavanagimatt, Kris Holt, Ying Tan, Melialani A. C. L. S. Anderson, Dennis E. Hruby
Filed: 15 Feb 17
Utility
ST-246 (tecovirimat monohydrate) SUSPENSION FORMULATIONS
15 Jul 21
The present invention is directed to a dry suspension for reconstitution containing Tecovirimat (ST-246) powder and simethicone.
Shanthakumar R. TYAVANAGIMATT, Kris HOLT, Ying TAN, Melialani A.C.L.S. ANDERSON, Dennis E. HRUBY
Filed: 15 Feb 17
Utility
Polymorphic Forms of ST-246 and Methods of Preparation
13 May 21
Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
Filed: 29 Dec 20
Utility
Polymorphic forms of ST-246 and methods of preparation
2 Mar 21
Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William C. Weimers, Dylan Nelson, Toveā² C. Bolken, Dennis E. Hruby, Michael H. O'Neill, Gary Sweetapple, Kelley A. McCloughan
Filed: 24 Jul 19
Utility
ST-246 liquid formulations and methods
14 Dec 20
The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove C. Bolken, Dennis E. Hruby
Filed: 1 Jan 20
Utility
Rehydration of micronized tecovirimat monohydrate
20 Jul 20
Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
Shanthakumar R. Tyavanagimatt, Matthew Reeves, N K Peter Samuel, Steven Priebe, Ying Tan, Dennis E. Hruby
Filed: 22 Jul 19
Utility
Methods of preparing tecovirimat
25 May 20
Disclosed are methods for the preparation of Tecovirimat for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the orthopoxvirus.
Dongcheng Dai
Filed: 8 Nov 18
Utility
ST-246 Liquid Formulations and Methods
6 May 20
The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William WEIMERS, Gopi Krishna KASI, N K Peter SAMUEL, Tove C. Bolken, Dennis E. HRUBY
Filed: 1 Jan 20
Utility
ST-246 liquid formulations and methods
2 Mar 20
The present invention provides for a novel liquid formulation for solubilizing poorly soluble ST-246 in cyclodextrins and a novel process of making the formulation.
Shanthakumar R. Tyavanagimatt, Melialani A. C. L. S. Anderson, William Weimers, Gopi Krishna Kasi, N K Peter Samuel, Tove C. Bolken, Dennis E. Hruby
Filed: 10 Oct 18
Utility
Rehydration of Micronized Tecovirmimat Monohydrate
18 Dec 19
Disclosed are methods for hydration of ST-246 particles comprising exposing said particles to moisture by conveying volumes of air containing moisture.
Shanthakumar R. TYAVANAGIMATT, Matthew Reeves, N K Peter SAMUEL, Steven PRIEBE, Ying TAN, Dennis E. HRUBY
Filed: 22 Jul 19
Utility
Polymorphic Forms of ST-246 and Methods of Preparation
13 Nov 19
Polymorph forms of 4-trifluoromethyl-N-(3,3a,4,4a,5,5a,6,6a-octahydro-1,3-dioxo-4,6-ethenocycloprop[f]isoindol-2(1H)-yl)-benzamide are disclosed as well as their methods of synthesis and pharmaceutical compositions.
Shanthakumar R. TYAVANAGIMATT, Melialani A.C.L.S. ANDERSON, William C. WEIMERS, Dylan NELSON, Tove' C. BOLKEN, Dennis E. HRUBY, Michael H. O'NEILL, Gary SWEETAPPLE, Kelley A. McCLOUGHAN
Filed: 23 Jul 19
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