51 patents
Utility
Method of preparing pyrimidine cyclohexyl glucocorticoid receptor modulators
28 Nov 23
The present invention provides methods of preparing 2-amino-6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidin-4(3H)-one, and 2-amino-6-((1r,4r)-4-phenylcyclohexyl)-5-(3-(trifluoromethyl)benzyl)pyrimidin-4(3H)-one monohydrate, as well as new intermediate compounds.
Jeffrey Mark Dener, Hazel Joan Hunt, Nicholas David Tyrrell
Filed: 20 Dec 21
Utility
Methods of treating neuroepithelial tumors using selective glucocorticoid receptor modulators
24 Oct 23
Applicant discloses methods for treating a glucocorticoid receptor positive (GR+) neuroepithelial tumor in a subject, comprising administering a selective glucocorticoid receptor modulator (SGRM) in an amount effective to reduce the tumor load in subject.
Andreas G. Moraitis
Filed: 19 Nov 21
Utility
Quaternary indazole glucocorticoid receptor antagonists
17 Oct 23
The present disclosure provides compounds of Formula I or II.
Hazel Hunt, Lorna Duffy, Ian Strutt, Morgan Jouanneau, Thomas Hornsby, Mark Mills, Andrew William Phillips, Jon-Paul Ward
Filed: 21 Jun 21
Utility
Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
19 Sep 23
The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.
Hazel Joan Hunt, Lorraine Donaghy, Keith Lorimer, Nathan Jay Dixon, Jeffrey Mark Dener
Filed: 5 Dec 22
Utility
Use of cortisol in assessment and prophylactic treatment of hypokalemia associated with glucocorticoid receptor modulator treatment of Cushing's syndrome patients
5 Sep 23
This invention provides new methods for a) identifying Cushing's Syndrome patients at high risk of developing hypokalemia during glucocorticoid receptor modulator (GRM) treatment, and b) for prophylactically treating such patients to prevent, or reduce the severity of, hypokalemia.
Andreas Moraitis
Filed: 31 Jul 20
Utility
Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
27 Jun 23
Andreas Moraitis
Filed: 20 Dec 22
Utility
Glucocorticoid receptor modulators to treat cervical cancer
30 May 23
Methods for treating a subject having a cancerous tumor are disclosed.
Hazel Hunt
Filed: 2 Dec 20
Utility
Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
16 May 23
The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators, including their use for treating amyotrophic lateral sclerosis (ALS).
Hazel Hunt, Tony Johnson, Nicholas Ray, Iain Walters
Filed: 28 Jul 21
Utility
Glucocorticoid receptor modulators to treat pancreatic cancer
9 May 23
Hazel Hunt, Thaddeus S. Block
Filed: 21 Oct 20
Utility
Systems and methods of managing treatment of a chronic condition by symptom tracking
21 Mar 23
Devices, systems, and methods for use in managing treatment of a chronic disorder with pharmaceutical or therapeutic compounds by tracking symptoms associated with the disorder.
Steven Lo, David Penake, John Lyons, Lisa Saginian
Filed: 16 Apr 18
Utility
Therapeutic uses of relacorilant, a heteroaryl-ketone fused azadecalin glucocorticoid receptor modulator
28 Feb 23
Andreas Moraitis
Filed: 9 Jun 21
Utility
Fatty liver disease treatment using glucocorticoid and mineralocorticoid receptor antagonists
28 Feb 23
The present invention provides treatment of fatty liver disease using a class of pyrimidinedione cyclohexyl compounds.
Joseph K. Belanoff, Hazel Hunt, Onno C. Meijer, José van den Heuvel
Filed: 3 Dec 20
Utility
Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
14 Feb 23
The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Hazel Hunt, Tony Johnson, Nicholas Ray, Iain Walters
Filed: 12 Jan 21
Utility
Octahydro fused azadecalin glucocorticoid receptor modulators
24 Jan 23
The present invention provides octahydro fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
Hazel Hunt, Iain Walters, Benoit Gourdet
Filed: 12 Jan 21
Utility
Polymorphs of pyrimidine cyclohexyl glucocorticoid receptor modulators
10 Jan 23
The present invention provides crystalline forms of (E)-6-(4-Phenylcyclohexyl)-5-(3-trifluoromethylbenzyl)-1H-pyrimidine-2,4-dione, and methods of making and using the same.
Hazel Joan Hunt, Lorraine Donaghy, Keith Lorimer, Nathan Jay Dixon, Jeffrey Mark Dener
Filed: 5 May 21
Utility
Pyrimidine cyclohexenyl glucocorticoid receptor modulators
3 Jan 23
The present invention provides a class of pyrimidinedione cyclohexenyl compounds and methods of using these compounds as glucocorticoid receptor modulators.
Hazel Hunt, Damien Francis Philippe Crepin, Joseph Thomas Hill-Cousins, Thomas Matthew Baker, Lorna Duffy
Filed: 3 Jun 19
Utility
Treatment of hypercoagulopathy in Cushing's syndrome by administration of glucocorticoid receptor modulators
13 Dec 22
Andreas G. Moraitis
Filed: 20 Dec 19
Utility
Pharmaceutical formulations containing relacorilant, a heteroaryl-ketone fused azadecalin compound
11 Oct 22
Disclosed herein are novel formulations containing relacorilant ((R)-(1-(4-fluorophenyl)-6-((1-methyl-1H-pyrazol-4-yl)sulfonyl)-4,4a,5,6,7,8-hexahydro-1H-pyrazolo[3,4-g]isoquinolin-4a-yl)(4-(trifluoromethyl)pyridin-2-yl)methanone) that are suitable for administration, including oral administration, to patients suffering from disorders amenable to treatment by glucocorticoid receptor modulators (GRMs).
Ian Scott, Travis Lemons, Yip-Fong Chia
Filed: 18 Dec 19
Utility
Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
19 Jul 22
Andrew Greenstein, Stacie Shepherd, Andreas G. Moraitis
Filed: 18 Dec 19
Utility
Treatment and differential diagnosis of Cushing's disease and ectopic Cushing's syndrome
10 May 22
Improved methods and systems for diagnosing and for treating Cushing's syndrome and Cushing's Disease are provided herein, including methods and systems for concurrently treating Cushing's syndrome and differentially diagnosing Cushing's Disease from Ectopic Cushing's Syndrome in a patient with an established diagnosis of ACTH-dependent Cushing's syndrome.
Andreas G. Moraitis
Filed: 12 Oct 18