52 patents
Utility
Lipo-glycopeptide cleavable derivatives and uses thereof
2 Jan 24
The present invention provides certain lipo-glycopeptide cleavable derivatives and methods for using the same for the treatment of bacterial infections, for example, pulmonary bacterial infections.
Ryan Heckler, Donna Konicek, Adam Plaunt, Vladimir Malinin, Walter Perkins
Filed: 10 Jun 21
Utility
Systems for Treating Pulmonary Infections
26 Oct 23
Provided herein are systems for treating a subject with a pulmonary infection, for example, a nontuberculous mycobacterial pulmonary infection, a Burkholderia pulmonary infection, a pulmonary infection associated with bronchiectasis, or a Pseudomonas pulmonary infection.
Walter PERKINS, Vladimir MALININ, Xingong LI, Brian MILLER, Dominique SEIDEL, Philipp HOLZMANN, Harald SCHULZ, Michael HAHN
Filed: 2 May 23
Utility
Prostacyclin compounds, compositions and methods of use thereof
24 Oct 23
Prostacyclin compounds and compositions comprising the same are provided herein.
Vladimir Malinin, Walter Perkins, Franziska Leifer, Donna Konicek, Zhili Li, Adam Plaunt
Filed: 26 Feb 21
Utility
Methods for Treating Pulmonary Non-tuberculous Mycobacterial Infections
19 Oct 23
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle.
Gina EAGLE, Renu GUPTA
Filed: 8 Aug 22
Utility
Methods for Extracting Neutrophil Serine Proteases and Treating Dipeptidyl Peptidase 1-MEDIATED Conditions
5 Oct 23
Jessica BASSO, Jimin ZHANG, David C. CIPOLLA
Filed: 19 Jul 21
Utility
Dry powder compositions of treprostinil prodrugs and methods of use thereof
19 Sep 23
Ju Du, Adam Plaunt, Vladimir Malinin
Filed: 23 Aug 22
Utility
Methods of Manufacturing Treprostinil and Treprostinil Derivative Prodrugs
10 Aug 23
Methods for making prodrugs of trepreostinil and treprostinil derivatives are provided.
Vladimir MALININ, Walter PERKINS, Fraziska LEIFER, Donna M. KONICEK, Zhili LI, Adam PLAUNT
Filed: 18 Apr 23
Utility
Methods for Continuous Manufacture of Liposomal Drug Products
13 Jul 23
Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes.
Robert WORSHAM
Filed: 30 Dec 22
Utility
Antibodies and methods of making same
16 May 23
Provided are variants of a chimeric anti-EGFR antibody.
Karl Edwin Griswold, Chris Bailey-Kellogg, Yoonjoo Choi
Filed: 24 May 17
Utility
Lipid-based Compositions of Antiinfectives for Treating Pulmonary Infections and Methods of Use Thereof
4 May 23
A system for treating or providing prophylaxes against a pulmonary infection is disclosed comprising: a) a pharmaceutical formulation comprising a mixture of free antiinfective and antiinfective encapsulated in a lipid-based composition, and b) an inhalation delivery device.
Jeff WEERS
Filed: 22 Dec 22
Utility
Methods for Treating Pulmonary Non-tuberculous Mycobacterial Infections
9 Feb 23
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle.
Gina EAGLE, Renu GUPTA
Filed: 7 Oct 22
Utility
Methods for continuous manufacture of liposomal drug products
7 Feb 23
Provided herein are methods for making liposomal API formulations via continuous in-line diafiltration processes.
Robert Worsham
Filed: 29 Mar 19
Utility
Sustained Release of Antiinfectives
12 Jan 23
Provided are lipid antiinfective formulations substantially free of anionic lipids with a lipid to antiinfective ratio is about 1:1 to about 4:1, and a mean average diameter of less than about 1 µm.
Lawrence T. BONI, Brian S. MILLER, Vladimir MALININ, Xingong LI
Filed: 9 Sep 22
Utility
Dry Powder Compositions of Treprostinil Prodrugs and Methods of Use Thereof
29 Dec 22
Ju DU, Adam PLAUNT, Vladimir MALININ
Filed: 23 Aug 22
Utility
Methods for Treating Pulmonary Non-tuberculous Mycobacterial Infections
15 Dec 22
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle.
Gina EAGLE, Renu GUPTA
Filed: 21 Jun 22
Utility
Dry powder compositions of treprostinil prodrugs and methods of use thereof
4 Oct 22
Ju Du, Adam Plaunt, Vladimir Malinin
Filed: 28 Apr 20
Utility
Methods for treating pulmonary non-tuberculous mycobacterial infections
20 Sep 22
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle.
Gina Eagle, Renu Gupta
Filed: 15 Jul 20
Utility
Methods for treating pulmonary non-tuberculous mycobacterial infections
26 Jul 22
Provided herein are methods for treating a pulmonary infection in a patient in need thereof, for example, a nontuberculous mycobacterial pulmonary infection for at least one treatment cycle.
Gina Eagle, Renu Gupta
Filed: 24 Sep 20
Utility
Methods of Manufacturing Treprostinil and Treprostinil Derivative Prodrugs
5 May 22
Methods for making prodrugs of treprostinil and treprostinil derivatives are provided.
Vladimir MALININ, Walter PERKINS, Franziska LEIFER, Donna M. KONICEK, Zhili LI, Adam PLAUNT
Filed: 9 Sep 21
Utility
Certain (2S)-N-[(1S)-1-CYANO-2-PHENYLETHYL]-1,4-OXAZEPANE-2-CARBOXAMIDES for Treating Bronchiectasis
5 May 22
Hans Roland LONN, Stephen CONNOLLY, Steven SWALLOW, Reinilde HEYRMAN, Eugene SULLIVAN, Carlos FERNANDEZ
Filed: 14 Jan 22