1310 patents
Utility
Combination Therapy for the Treatment of Cancer
18 Jan 24
The present disclosure relates to a pharmaceutical combination comprising (1) a first agent which is a CDK inhibitor or a pharmaceutically acceptable salt thereof and (2) a second agent which is an anti-hormonal agent or a pharmaceutically acceptable salt thereof.
Yan CHEN, Xizhong HUANG, Sunkyu KIM
Filed: 19 Sep 23
Utility
Synthesis of Prostate Specific Membrane Antigen (Psma) Ligands
18 Jan 24
The present disclosure relates to the synthesis of prostate specific membrane antigen (PSMA) ligands that are useful in the treatment of diseases like cancer.
Fritz ANDREAE
Filed: 19 Nov 21
Utility
Manufacture of compounds and compositions for inhibiting the activity of SHP2
16 Jan 24
Zhongbo Fei, Huanqing Jia, Wei Li, Xiaohui Lin, Zhongcheng Min, Hui Wang, Jianhua Wang, Hao Zhang
Filed: 18 Sep 19
Utility
Method of treating cancer by administering immune effector cells expressing a chimeric antigen receptor comprising a CD20 binding domain
16 Jan 24
The invention provides compositions and methods for treating diseases associated with expression of CD20 or CD22.
Barbara Brannetti, Jennifer Brogdon, Boris Engels, Brian Walter Granda, Lu Huang, Ming Lei, Na Li, Jimin Zhang, Carla Patricia Pinto Guimaraes, Saar Gill, Marco Ruella, Regina M. Young
Filed: 30 Apr 21
Utility
Compounds and Compositions for Treating Solid Tumors by Intratumoral Administration
11 Jan 24
Michael Cooke, Shailaja Kasibhatla, Andrew T. Miller, Tom Yao-Hsiang Wu
Filed: 28 Jul 23
Utility
1,4-DISUBSTITUTED Pyridazine Quinolne Analogs There of and Methods for Treating Smn-deficiency-related Conditions
11 Jan 24
Atwood Kim CHEUNG, Natalie Alysia DALES, Timothy Brian HURLEY
Filed: 23 May 23
Utility
Drug Delivery Systems
11 Jan 24
The present invention relates to thermogelling peptide delivery systems which are injected as fluid sol at ambient temperature through thin injection needles and transform into a highly viscous gel once inserted into human or animal body warm tissue.
Stephanie SUPPER
Filed: 22 Sep 23
Utility
Synthesis of Prostate Specific Membrane Antigen (Psma) Ligands
11 Jan 24
The present disclosure relates to the synthesis of prostate specific membrane antigen (PSMA) ligands that are useful in the treatment of diseases like cancer.
Fritz ANDREAE
Filed: 19 Nov 21
Utility
Treatments for Retinal Degenerative Diseases
11 Jan 24
Methods for treating or improving a retinal degenerative disease or condition in a subject in need thereof are provided.
Yi BAO, Qian HUANG, Joshua SCHUSTAK, Michael Zbigniew TWAROG
Filed: 9 Aug 21
Utility
Formulations of (S)-3-amino-6-methoxy-N-(3,3,3-trifluoro-2-hydroxy-2-methylpropyl)-5-(trifluoromethyl)picolinamide
9 Jan 24
Provided herein are compounds and pharmaceutical compositions useful for treating bronchiectasis, chronic obstructive pulmonary disorder, cystic fibrosis, chronic bronchitis or asthma comprising administering to a subject in need thereof a therapeutically effective amount of a compound or pharmaceutical composition described herein.
Vivek Dubey, Rohit Lowalekar, Paulo G. Santos, Hubert Thoma, Xianbin Tian
Filed: 15 Jul 20
Utility
Treatment of cancer using humanized anti-EGFRvIII chimeric antigen receptor
9 Jan 24
The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII.
Jennifer Brogdon, Laura Alexandra Johnson, Carl H. June, Andreas Loew, Marcela Maus, John Scholler, Hideho Okada
Filed: 12 Apr 19
Utility
Optimized lentiviral transfer vectors and uses thereof
9 Jan 24
The invention features lentiviral transfer vectors that include heterologous nucleic acids to be introduced into a cell.
Vladimir Slepushkin, Dmitriy Lukashev
Filed: 23 Nov 21
Utility
Use of an Erk Inhibitor for the Treatment of Myelofibrosis
4 Jan 24
The invention relates to the use of an ERK inhibitor in the treatment of myelofibrosis (MF).
Sime BRKIC, Hans MENSSEN, Sara MEYER, Thomas RADIMERSKI, Simona STIVALA
Filed: 7 Oct 21
Utility
Compositions and Methods for the Treatment of Hemoglobinopathies
4 Jan 24
The present invention is directed to genome editing systems, reagents and methods for the treatment of hemoglobinopathies.
Anthony Edward BOITANO, Michael COOKE, Lloyd B. KLICKSTEIN, Reynald LESCARBEAU, Craig Stephen MICKANIN, Kabungo MULUMBA, Seshidhar Reddy POLICE, Jennifer SNEAD, Susan C. STEVENSON, Morag STEWART, Yi YANG
Filed: 13 Oct 22
Utility
Therapeutic Combinations Comprising a Craf Inhibitor
4 Jan 24
The present invention provides a pharmaceutical combination comprising a CRAF inhibitor in combination with (i) an ERK inhibitor or (ii) a MEK inhibitor or (iii) a CDK4/6 inhibitor, each as defined herein, or independently in each case a pharmaceutically acceptable salt thereof, for use in the treatment of NRAS-mutant melanoma and in the treatment of BRAF-mutant melanoma. wherein the melanoma may be unresectable and/or metastatic melanoma.
Giordano Caponigro, Vesselina Cooke, Uz Martin Stammberger, Darrin Stuart
Filed: 11 May 21
Utility
ANTIBODY Fc VARIANTS
4 Jan 24
The present invention relates to antibodies comprising Fc variants and their uses.
Brian Walter GRANDA, Darko SKEGRO
Filed: 4 Nov 21
Utility
Humanization of rabbit antibodies using a universal antibody framework
2 Jan 24
The present invention relates to an universal antibody acceptor framework and to methods for grafting non-human antibodies, e.g., rabbit antibodies, using a universal antibody acceptor framework.
Leonardo Borras, David Urech
Filed: 18 Dec 17
Utility
Bcma Chimeric Antigen Receptors and Uses Thereof
28 Dec 23
The invention provides compositions and methods for treating diseases associated with expression of BCMA.
Aida Abujoub, John Blankenship, Dexiu Bu, Tony Fleming, Brian Holmberg, Connie Hong, Lu Huang, Chonghui Zhang
Filed: 16 Mar 23
Utility
FGF21 Mimetic Antibodies and Uses Thereof
28 Dec 23
The present disclosure relates to monoclonal antibodies and antigen-binding fragments thereof that bind to human β-klotho, and pharmaceutical compositions and methods of treatment comprising the same.
Regis CEBE, Stephane OLLAND, David Langdon YOWE
Filed: 15 May 23
Utility
Compounds and Compositions for Treating Conditions Associated with NLRP Activity
28 Dec 23
Luigi FRANCHI, Shomir GHOSH, Gary GLICK, Jason KATZ, Anthony William OPIPARI, William ROUSH, Hans Martin SEIDEL, Dong-Ming SHEN, Shankar VENKATRAMAN, David Guenther WINKLER
Filed: 18 May 23