818 patents
Utility
A Wearable Medical Device
18 Jan 24
A wearable medical device includes: a spatial sensor configured to determine distance to objects in an environment in front of the spatial sensor; an acoustic signal generator operable to generate an acoustic signal; a processor; and a memory configured to store instructions which, when executed the processor, cause the wearable medical device to: detect, using the spatial sensor, objects in the environment, calculate the distance to objects detected in the environment, and when the distance to an object is less than a predetermined value, control the acoustic signal generator to generate a first alert.
Michael Helmer, Martin Vitt
Filed: 1 Nov 21
Utility
Drug Delivery Device
18 Jan 24
A drug delivery device includes a housing element, a protection member, a moveable member, a first stop feature, a second stop feature configured to interact with the first stop feature, wherein the drug delivery device is configured to perform a drug delivery operation, wherein the drug delivery device is configured to be switchable from an initial state into a released state, wherein in the released state (i) the protection member is in a proximal position, and (ii) the moveable member moves into a locking position, and wherein the drug delivery device is configured to be switchable from the released state into a post-released state by moving the protection member from the proximal position in a distal direction into a post-release position, wherein in the post-released state (i) the protection member is in the post-release position and (ii) the moveable member is in the locking position.
Uwe Dasbach, Timothy Denyer, Thomas Mark Kemp, Chris Rosier, Robbie Wilson
Filed: 1 Dec 21
Utility
Methods for Purification of Multi-specific Antibodies
18 Jan 24
Provided are multivalent binding proteins comprising four polypeptide chains, wherein a first heavy chain polypeptide and a first light chain polypeptide associate to form one or more antigen binding domains and a second heavy chain polypeptide and a second light chain polypeptide associate to bind one or more antigen binding domains.
Ercole RAO, David J. Reczek, Tingwan Sun, Lena Wahl
Filed: 8 Jun 23
Utility
Drive train for dial of a torsion-spring assisted wind-up injection device
16 Jan 24
A drive train for a wind-up injection device is described.
Michael Jugl, Stefan Blancke, Axel Teucher, Ralph Donald Quentin Collings, James Robert Coop, James Anthony West, Stephen Francis Gilmore, Daniel David Higgins, Mark Digby Teucher, Anthony Paul Morris, Matthew Meredith Jones, William Geoffrey Arthur Marsh, Samuel Keir Steel
Filed: 22 Jan 18
Utility
A User Device Configured to Communicate Wirelessly With a Storage Device
11 Jan 24
A user device configured to communicate wirelessly with a storage device is described.
Hardy Kietzmann, Pablo Prados
Filed: 1 Dec 21
Utility
Therapeutic RNA
9 Jan 24
This disclosure relates to the field of therapeutic RNAs for treatment of solid tumor cancers.
Friederike Gieseke, Ugur Sahin, Timothy R. Wagenaar, Dmitri G. Wiederschain, Christian Hotz
Filed: 30 Apr 21
Utility
Injection device
9 Jan 24
A handheld injection device includes a housing containing a cartridge, a dose setting means being operable in a first direction to set a desired dose to be dispensed, a piston rod being adapted to cooperate with a piston so as to cause a set dose to be injected from the cartridge, and a first clicker component, which is largely rotationally constrained to the housing, and a second clicker component, which is rotatable relative to the housing during dose dispensing.
Anthony Paul Morris
Filed: 18 Jun 19
Utility
Injection device with dose size adjuster
9 Jan 24
The present disclosure relates to an injection device configured to expel a dose of a medicament, the injection device comprising: an elongated housing extending in a longitudinal direction, a piston rod movable relative to the housing in a longitudinal distal direction to exert a dispensing pressure onto a bung of a cartridge at least partially filled with an injectable medicament, a rod extension movably arranged on or in a distal end of the piston rod, a driver operably engaged with the piston rod and movable relative to the housing in a longitudinal proximal direction for setting of the dose and movable relative to the housing in the longitudinal distal direction for dispensing of the dose, and an adjuster arranged on or in the driver and operably engaged with the rod extension to move the rod extension in longitudinal direction relative to the piston rod.
Michael Jugl, Stefan Blancke
Filed: 27 Feb 19
Utility
RFID dose tracking mechanism for injection devices
9 Jan 24
Described is a dose tracking mechanism for a drug delivery device, including a moveable component configured to move with respect to a housing during operation of the drug delivery device and an RFID device with an electric circuit having a resonance frequency.
Markus Ploch, Maurice Toporek
Filed: 18 Dec 18
Utility
Panel of ER Regulated Genes for Use in Monitoring Endocrine Therapy in Breast Cancer
4 Jan 24
The present disclosure relates to a panel of ER regulated genes and method for using the panel for monitoring the response of an individual having cancer to treatment with amcenestrant, the method comprising determining a first ER activity score from a sample from the individual at a first time point before treatment with amcenestrant using the panel, then determining a second ER activity score from a sample from the individual at a second time point following administration of amcenestrant using the panel, and comparing the first ER activity score with the second ER activity score, wherein a decrease in the second ER activity score relative to the first ER activity score is predictive of target engagement of amcenestrant.
Monsif Bouaboula, Hui Cao, Joon Sang Lee, Vasiliki Pelekanou, Maysoun Shomali
Filed: 22 Nov 21
Utility
Drug Delivery Device
4 Jan 24
A drug delivery device includes a housing element, a protection member, a movable member, wherein the drug delivery device has an initial state, in which (i) the protection member is in an extended position to cover the drug delivery element, (ii) the protection member is movable in a proximal direction from the extended position into a retracted position in order to expose the drug delivery element, and (iii) the protection member is coupled to the movable member in distal direction and proximal direction such that an axial movement of the protection member in both, the distal and proximal direction, results in an axial movement of the movable member in the same direction.
Uwe Dasbach, Thomas Mark Kemp, Timothy Denyer, Robbie Wilson, Chris Rosier
Filed: 1 Dec 21
Utility
Method and Device for Determining or Testing the Mechanical Integrity of Medicament Containers
4 Jan 24
The present disclosure relates to a method of determining or estimating a burst pressure resistance of a batch of medicament containers, wherein each medicament container of the batch of medicament containers includes a vitreous barrel filled with a liquid substance and is sealed by a stopper slidably disposed inside of the vitreous barrel.
Christophe Agut, Paolo Mangiagalli, Stefano Martini, Cinzia Rotella
Filed: 15 Nov 21
Utility
User Device and Method for Monitoring Use of an Injection Device and for Monitoring a Disease Progression
4 Jan 24
A user device configured to monitor use of an injection device and disease progression is described.
Hardy Kietzmann, Pablo Prados
Filed: 1 Dec 21
Utility
Classifying Images of Dose-Response Graphs
4 Jan 24
A computer-implemented method of classifying images comprising dose-response graphs obtained from dose-response experiments.
Marc Bianciotto, Kun Mi
Filed: 29 Nov 21
Utility
Device for attachment to an injection device
2 Jan 24
A supplementary device configured to be attached to a drug delivery device, the supplementary device including: first means being adapted to mechanically couple the supplementary device to a dosage selector of the drug delivery device; second means being adapted to select a dosage to be delivered by the drug delivery device; third means being adapted to mechanically couple the second means to the first means such that a dosage selection made with the second means generates a torque being transferred via the third means to the first means; a sensor configured to output signals indicative of the generated torque; and electronics configured to receive the signals output from the sensor and to determine based on the signals the selected dosage.
Michael Helmer, Christian Rehbein
Filed: 17 Dec 18
Utility
Device for managing a medication regime
2 Jan 24
A device for communicating a driving ability level of a user, the device comprising at least a processor, a memory, and a wireless transceiver.
Michael Helmer
Filed: 3 Aug 22
Utility
Drug Delivery Device and Charging Device
28 Dec 23
A drug delivery device for delivering a medicament includes a housing arranged to contain a container, a receiver coil, and an energy storage unit.
Atul Nayak
Filed: 8 Sep 23
Utility
Arrangement for a Drug Delivery Device and Drug Delivery Device
28 Dec 23
An arrangement for a drug delivery device includes a housing element, a plunger rod that is axially movable with respect to the housing element, a feedback element that is axially movable with respect to the housing element and with respect to the plunger rod, a feedback energy member configured to provide energy to induce a movement of the feedback element relative to the plunger rod in a first axial direction, and a radially displaceable stop feature and an impact feature.
Uwe Dasbach, Thomas Mark Kemp, Timothy Denyer, Robbie Wilson, Chris Rosier
Filed: 1 Dec 21
Utility
MULTIFUNCTIONAL NATURAL KILLER (NK) CELL ENGAGERS BINDING TO NKp46 AND CD123
28 Dec 23
Marielle CHIRON, Angela Virone-Oddos, Laurent Gauthier
Filed: 28 Apr 23
Utility
ANTI-CD38 Antibodies and Formulations
28 Dec 23
Provided herein are antibodies that specifically bind human CD38, formulations and unit dosage forms comprising the antibodies, methods of preparing the antibodies and methods of using the antibodies.
Marielle CHIRON BLONDEL, Cendrine LEMOINE, Angela VIRONE-ODDOS, BĂ©atrice CAMERON, Jacques DUMAS, Alain FOURNIER, Jonathan KINGSBURY, Brian MURRAY, Nathan OSTBERG, Sanket PATKE, Zichuan ZHANG
Filed: 14 Apr 23