88 patents
Utility
GHB Formulation and Method for Its Manufacture
18 Jan 24
The present application relates to GHB formulations and methods for manufacturing the same.
Clark ALLPHIN, Scott BURA
Filed: 25 Sep 23
Utility
Fused bicyclic RAF inhibitors and methods for use thereof
2 Jan 24
The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof.
Andrew Belfield, Clifford David Jones, Jean-François Margathe, Chiara Colletto
Filed: 28 Jul 21
Utility
Sodium Oxybate to Treat Idiopathic Hypersomnia
21 Dec 23
The present disclosure relates to methods of treating idiopathic hypersomnia with oxybate, preferably sodium oxybate.
Franck SKOBIERANDA, Dan CHEN, Amanda Leigh STERKEL
Filed: 8 Oct 21
Utility
Treatment Methods Using GHB
7 Dec 23
Provided herein are methods of treating fibromyalgia, post-traumatic stress disorder, irritable bowel syndrome, and irritable bowel disease in a patient with a slow wave sleep deficit by administering oxybate or a pharmaceutically acceptable salt thereof.
Franck SKOBIERANDA, Mark Toddman KIRBY
Filed: 18 Oct 21
Utility
Euglobulin-based Method for Determining the Biological Activity of Defibrotide
9 Nov 23
It is disclosed a method for determining the biological activity of defibrotide, which comprises the steps of: a) bringing into contact defibrotide, mammalian euglobulin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide.
Terenzio IGNONI, Vijay KUMAR, Khalid ISLAM
Filed: 12 Jul 23
Utility
Ras Inhibitors and Methods of Using the Same
26 Oct 23
Provided herein are compounds identified as inhibitors of KRAS protein activity that can be used to treat various diseases and disorders, such as cancer.
Andrew BELFIELD, Nicolas Emmanuel Stephane GUISOT, Clifford David JONES, Chiara COLLETTO
Filed: 29 Jan 21
Utility
Euglobulin-based method for determining the biological activity of defibrotide
5 Sep 23
It is disclosed a method for determining the biological activity of defibrotide, which comprises the steps of: a) bringing into contact defibrotide, mammalian euglobulin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed at successive times, to thereby determine the biological activity of the defibrotide.
Terenzio Ignoni, Vijay Kumar, Khalid Islam
Filed: 6 Aug 21
Utility
Defibrotide Treatment for the Prevention of Organ Rejection and Injury
23 Mar 23
The present disclosure provides methods of preventing, lessening the effects, or treating organ injury and/or organ rejection optionally associated with organ transplant comprising administering defibrotide.
Polly Rae PINE, Ranjesh HANVESAKUL
Filed: 16 Apr 21
Utility
Methods for Treating Patients Having Sinusoidal Obstruction Syndrome
16 Mar 23
In various embodiments, the present disclosure teaches methods of treating patients diagnosed as having sinusoidal obstruction syndrome with defibrotide.
Massimo IACOBELLI
Filed: 8 Aug 22
Utility
Defibrotide for the prevention and treatment of cytokine release syndrome and neurotoxicity associated with immunodepletion
7 Feb 23
The present disclosure provides method of preventing, lessening the effects, or treating cytokine release syndrome (CRS) or related disorders, and/or neurotoxicity associated with immunotherapy comprising administering defibrotide.
Sarah McMahon, Yasuhiro Oki
Filed: 12 Apr 19
Utility
Gamma-hydroxybutyrate compositions and their uses for the treatment of disorders
17 Jan 23
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB).
Clark P. Allphin, Michael DesJardin
Filed: 12 May 20
Reissue
Fused bicyclic (hetero)aromatic compounds useful for the treatment of cancers
10 Jan 23
This invention relates to novel compounds.
Matilda Bingham, Richard Testar, Camille Gignoux
Filed: 24 Nov 20
Utility
Gamma-hydroxybutyrate Compositions and Their Use for the Treatment of Disorders
17 Nov 22
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB).
Clark P. ALLPHIN, Gunjan JUNNARKAR, Roman SKOWRONSKI, Cuiping CHEN, Katayoun ZOMORODI, Mark ELLER
Filed: 8 Jul 22
Utility
Sensitive drug distribution systems and methods
27 Sep 22
A drug distribution system and method utilizes a central pharmacy and database to track all prescriptions for a sensitive drug.
Prasheel Vashdev Lillaney, Sherice Reneé Mills, Gary Joseph Appio
Filed: 11 Jul 18
Utility
Gamma-hydroxybutyrate compositions and their use for the treatment of disorders
30 Aug 22
Provided herein are pharmaceutical compositions and formulations comprising mixed salts of gamma-hydroxybutyrate (GHB).
Clark P. Allphin, Gunjan Junnarkar, Roman Skowronski, Cuiping Chen, Katayoun Zomorodi, Mark Eller
Filed: 22 Dec 20
Utility
Carbamoyl phenylalaninol analogs and uses thereof
16 Aug 22
The present invention relates to carbamoyl phenylalaninol analogs and methods of using the same to treat disorders.
Fionn Hurley
Filed: 31 Jul 18
Utility
Sensitive drug distribution systems and methods
9 Aug 22
A drug distribution system and method utilizes a central pharmacy and database to track all prescriptions for a sensitive drug.
Prasheel Vashdev Lillaney, Sherice Reneé Mills, Gary Joseph Appio
Filed: 11 Jul 18
Utility
Alcohol-resistant drug formulations
2 Aug 22
The invention relates to modified release oral formulations of therapeutic agents, including gamma hydroxybutyrate (GHB), paracetamol, codeine or oxycodone, which are resistant to alcohol induced dose dumping.
Edwin Walsh, Clark Patrick Allphin
Filed: 19 Nov 19
Utility
Method of Administration of Gamma Hydroxybutyrate with Monocarboxylate Transporters
23 Jun 22
One embodiment of the present invention is to improve the safety and efficacy of the administration of GHB or a salt thereof to a patient.
Mark ELLER
Filed: 27 Dec 21
Utility
GHB formulation and method for its manufacture
21 Jun 22
The present application relates to GHB formulations and methods for manufacturing the same.
Clark Allphin, Scott Bura
Filed: 5 Apr 21