206 patents
Page 4 of 11
Utility
Fret-labeled Compounds and Uses Therefor
11 Aug 22
Reaction mixtures are provided having at least a first nucleotide analog and a second nucleotide analog that produce signals in response to excitation illumination.
Xiangxu Kong, Gene Shen
Filed: 25 Oct 21
Utility
Recombinant Polymerases for Incorporation of Protein Shield Nucleotide Analogs
28 Jul 22
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification.
Satwik Kamtekar, Erik Miller
Filed: 10 Nov 21
Utility
Integrated illumination of optical analytical devices
12 Jul 22
Optical analytical devices and their methods of use are provided.
Paul Lundquist, Stephen Turner
Filed: 24 Feb 20
Utility
Recombinant polymerases with increased phototolerance
5 Jul 22
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing.
Satwik Kamtekar, Lei Jia, Erik Miller
Filed: 18 Sep 20
Utility
Synthetic nucleic acids having non-natural structures
5 Jul 22
Nucleic acid compositions having nucleotide sequences that do not occur in nature are provided.
Arnold Oliphant, James Yu
Filed: 16 Jul 20
Utility
Modified nucleotide reagents
14 Jun 22
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Gene Shen, Stephen Yue, Lubomir Sebo, Louis Brogley
Filed: 13 Jun 19
Utility
Multi-amplitude Modular Labeled Compounds
2 Jun 22
Sets of compounds bearing detectably different groups of labels are provided.
Erik Miller, Satwik Kamtekar
Filed: 29 Oct 21
Utility
Intermittent Detection During Analytical Reactions
2 Jun 22
Methods, devices, and systems for performing intermittent detection during analytical reactions are provided.
Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid
Filed: 5 Nov 21
Utility
Illumination of Optical Analytical Devices
2 Jun 22
Optical analytical devices and their methods of use are provided.
Annette GROT, Shang WANG, Hans CALLEBAUT, Paul LUNDQUIST, Stephen TURNER
Filed: 4 Oct 21
Utility
Method and System for Sequencing Nucleic Acids
26 May 22
Provided are compositions, methods and systems for determining the sequence of a template nucleic acid using a polymerase-based, sequencing-by-binding procedure.
Kandaswamy VIJAYAN, Corey M. DAMBACHER, Eugene TU, Mark A. BERNARD, Joseph ROKICKI, Kerry WILSON
Filed: 6 Oct 21
Utility
Increased signal to noise in nucleic acid sequencing
24 May 22
A method for identifying a nucleotide in a template nucleic acid by (a) providing a plurality of primer-template nucleic acid hybrids, wherein the primers have an extendable 3′ end; (b) contacting the plurality with: (i) blocked nucleotides to produce a first subset of the primer-template nucleic acid hybrids that include a blocked nucleotide at the 3′ end, and (ii) a ternary complex inhibitor to produce a second subset of the primer-template nucleic acid hybrids that include a ternary complex inhibitor; (c) forming ternary complexes that each include a polymerase, a primer-template nucleic acid hybrid of the first subset, and a cognate nucleotide; and (d) detecting the ternary complexes, thereby identifying a nucleotide in the template nucleic acid.
Chad Fleischer, Denis Malyshev
Filed: 12 Apr 19
Utility
Methods and compositions for delivery of molecules and complexes to reaction sites
17 May 22
The present invention provides methods, compositions, and systems for distributing molecules and complexes into reaction sites.
Jaime Juan Benitez-Marzan, Natasha Popovich, Lei Sun
Filed: 28 Jun 19
Utility
Reversible Modification of Nucleotides
12 May 22
Denis Malyshev, Aaron W. Feldman
Filed: 17 Sep 21
Utility
Methods of quantifying target nucleic acids and identifying sequence variants
10 May 22
The present disclosure provides compositions, methods and systems for quantifying target sequences and identifying target sequence variants.
Yi Zhang, Steven Brentano, Eugene Tu, Kandaswamy Vijayan
Filed: 6 Apr 17
Utility
Compositions and Techniques for Nucleic Acid Primer Extension
5 May 22
A method of characterizing a nucleic acid that includes steps of (a) contacting a primer-template nucleic acid hybrid with a polymerase and a mixture of nucleotides to produce an extended primer hybrid and to form a stabilized ternary complex including the extended primer hybrid, the polymerase and a nucleotide cognate of the next base in the template, wherein the mixture contains nucleotide cognates of four different base types, wherein the nucleotide cognate of the first base type has a reversible terminator, and wherein nucleotide cognates of the second, third and fourth base types are extendable; (b) detecting the stabilized ternary complex to distinguish the next base from other base types in the template; and (c) determining the presence of a base multiplet in the template nucleic acid, the base multiplet including the first base type followed by the next base.
Denis Malyshev, Arnold Oliphant
Filed: 2 Aug 21
Utility
Articles Having Localized Molecules Disposed Thereon and Methods of Producing Same
31 Mar 22
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate.
David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron L. Cicero
Filed: 18 Oct 21
Utility
Temporal differential active pixel sensor
8 Mar 22
Provided are pixels, devices, systems, and methods relating to active pixel sensor in which each active pixel puts out a signal that represents a temporal differential.
Annette Grot, Stephen Turner, Steven Benjamin Warren
Filed: 5 Jun 20
Utility
Producing bragg gratings in optical waveguides
8 Mar 22
We describe methods of producing gratings such as Bragg gratings with optical waveguides.
Mark McDonald, Aaron Rulison, Paul Lundquist, Tsuei-Lian Wang, Deborah Pao-Tung Kwo, Shang Wang
Filed: 11 Apr 19
Utility
Single-molecule Nanofet Sequencing Systems and Methods
3 Mar 22
Real time electronic sequencing devices, chips, and systems are described.
Stephen Turner, Jonas Korlach, Satwik Kamtekar, Jeremiah Hanes
Filed: 10 Sep 21
Utility
Classification of Nucleic Acid Templates
27 Jan 22
Methods, compositions, and systems are provided for characterization of modified nucleic acids.
Benjamin Flusberg, Stephen Turner, Jon Sorenson, Kevin Travers, Cheryl Heiner
Filed: 26 Aug 20