206 patents
Page 5 of 11
Utility
Intermittent detection during analytical reactions
4 Jan 22
Methods, devices, and systems for performing intermittent detection during analytical reactions are provided.
Stephen Turner, Jon Sorenson, Kenneth Mark Maxham, John Eid
Filed: 21 Oct 19
Utility
Protected dye-labeled reagents
21 Dec 21
Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided.
Lubomir Sebo, Honey Osuna, Stephen Yue, Yuri Lapin
Filed: 31 Jan 20
Utility
Hierarchical silica lamella for magnetic nucleic acid extraction
14 Dec 21
Disclosed herein is a novel method to fabricate magnetic silica nanomembranes using thin polymer cores based on silica deposition and self-wrinkling induced by thermal shrinkage.
Kelvin Jeng-Fang Liu, Jeffrey Michael Burke
Filed: 30 Jun 20
Utility
Recombinant polymerases for incorporation of protein shield nucleotide analogs
14 Dec 21
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing or nucleic acid amplification.
Satwik Kamtekar, Erik Miller
Filed: 9 Mar 20
Utility
FRET-labeled compounds and uses therefor
30 Nov 21
FRET-labeled compounds are provided for use in analytical reactions.
Xiangxu Kong, Gene Shen
Filed: 27 Jan 20
Utility
Articles having localized molecules disposed thereon and methods of producing same
30 Nov 21
Methods of producing substrates having selected active chemical regions by employing elements of the substrates in assisting the localization of active chemical groups in desired regions of the substrate.
David R. Rank, Jeffery Wegener, Jonas Korlach, Daniel Roitman, Yue Xu, John Lyle, Stephen Turner, Paul Peluso, Geoff Otto, Ron L. Cicero
Filed: 14 Apr 20
Utility
Fluorescent Polymerase Enzyme Substrates Having Protein Shields
11 Nov 21
Compositions, methods, and systems are provided for fluorescent polymerase enzyme substrates comprising protein shields for improving enzyme photostability in single molecule real time sequencing.
Keith Bjornson, Jeremiah Hanes, Erik Miller, Satwik Kamtekar, Lubomir Sebo, Louis Brogley
Filed: 14 Apr 21
Utility
Illumination of Integrated Analytical Systems
4 Nov 21
An analytical device including an optically opaque cladding, a sequencing layer including a substrate disposed below the cladding, and a waveguide assembly for receiving optical illumination and introducing illumination into the device.
Adrian FEHR, Nathaniel Joseph McCAFFREY, Stephen TURNER
Filed: 30 Mar 21
Utility
Multi-amplitude modular labeled compounds
2 Nov 21
Sets of compounds bearing detectably different groups of labels are provided.
Erik Miller, Satwik Kamtekar
Filed: 24 Oct 18
Utility
Arrays of Integrated Analytical Devices
21 Oct 21
Arrays of integrated analytical devices and their methods for production are provided.
Annette GROT, Ravi SAXENA, Paul LUNDQUIST
Filed: 7 Dec 20
Utility
Methods and Compositions for Generating Asymmetrically-tagged Nucleic Acid Fragments
14 Oct 21
The present disclosure provides improved methods for generating asymmetrically-tagged nucleic acid constructs, compositions comprising such constructs, and kits and systems for generating such constructs.
Joan Wilson
Filed: 25 Jun 21
Utility
Single-molecule nanoFET sequencing systems and methods
12 Oct 21
Real time electronic sequencing devices, chips, and systems are described.
Stephen Turner, Jonas Korlach, Satwik Kamtekar, Jeremiah Hanes
Filed: 20 Sep 18
Utility
Nucleic acid sequencing with nanoscale electrode pairs
12 Oct 21
Sequencing methods, devices, and systems are described.
Stephen Turner, Jeremiah Hanes, Keith Bjornson
Filed: 30 Oct 19
Utility
Systems, Devices, and Methods for Improved Optical Waveguide Transmission and Alignment
7 Oct 21
Provided herein are systems, devices, and methods for improved optical waveguide transmission and alignment in an analytical system.
Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Russell BERMAN
Filed: 15 Mar 21
Utility
Illumination of optical analytical devices
5 Oct 21
Optical analytical devices and their methods of use are provided.
Annette Grot, Shang Wang, Hans Callebaut, Paul Lundquist, Stephen Turner
Filed: 1 Mar 20
Utility
Substrates and Optical Systems and Methods of Use Thereof
23 Sep 21
This invention provides devices for use in various analytical applications including single-molecule analytical reactions.
Cheng Frank Zhong, Paul Lundquist, Mathieu Foquet, Jonas Korlach, Hovig Bayandorian
Filed: 16 Mar 21
Utility
Highly Multiplexed Nucleic Acid Sequencing Systems
16 Sep 21
Provided herein are highly multiplexed optical analytical systems for improved nucleic acid sequencing.
Alexey KURITSYN, Mark MCDONALD, Aaron RULISON, Annette GROT
Filed: 18 Feb 21
Utility
Methods for Isolating Nucleic Acids
2 Sep 21
Compositions, methods and systems are provided for isolating nucleic acids.
Thang Pham, Arunashree Bhamidipati, Kevin Travers, Eric Olivares, Tyson A. Clark, Jonas Korlach
Filed: 26 Feb 21
Utility
Recombinant Polymerases for Improved Single Molecule Sequencing
26 Aug 21
Provided are compositions comprising recombinant DNA polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing.
Satwik Kamtekar, Lei Jia, Robin Emig, Erik Miller, Walter H. Lee, Molly He, Insil Park
Filed: 3 Mar 21
Utility
Methods and compositions for generating asymmetrically-tagged nucleic acid fragments
27 Jul 21
The present disclosure provides improved methods for generating asymmetrically-tagged nucleic acid constructs, compositions comprising such constructs, and kits and systems for generating such constructs.
Joan Wilson
Filed: 27 Jan 20