33 patents
Utility
High-strength Oral Taxane Compositions and Methods
12 Oct 23
Methods for improving bioavailability and solubility of taxanes provided as solids in compressed tablet form are described.
Weng Li YOON, Ming Tsung LEE, Jiahao LI, Denise So Bik CHAN, Johnson Yiu-Nam LAU
Filed: 22 May 23
Utility
Therapeutic combinations of orally administered irinotecan and a p-gp inhibitor for the treatment of cancer
12 Sep 23
The present disclosure provides pharmaceutical combinations of orally administered irinotecan and a P-gp inhibitor.
Min-Fun Rudolf Kwan, E. Douglas Kramer, David Lawrence Cutler, Johnson Yiu-Nam Lau, Wing Kai Chan
Filed: 16 Dec 19
Utility
Compositions and methods for treating hyperproliferative skin disorders
12 Sep 23
Compositions and methods are provided that are effective in treating skin hyperproliferative disorders.
Johnson Yiu-Nam Lau, Alissa Rae Verone-Boyle, Chun-Ho Wong, Yahao Bu, Murray John Cutler, Krista Elizabeth Belko, Min-Fun Rudolf Kwan
Filed: 6 Mar 19
Utility
Therapeutic Combinations of Orally Administered Docetaxel and a P-GP Inhibitor for the Treatment of Cancer
16 Feb 23
The present disclosure provides pharmaceutical combinations of orally administered docetaxel and a P-gp inhibitor.
Min-Fun Rudolf KWAN, E. Douglas KRAMER, David Lawrence CUTLER, Johnson Yiu-Nam LAU, Wing Kai CHAN
Filed: 13 Jun 22
Utility
Methods of treating and/or preventing actinic keratosis
15 Nov 22
Min-Fun Rudolf Kwan, Johnson Yiu-Nam Lau, E. Douglas Kramer, David Lawrence Cutler, Jane Fang
Filed: 28 Feb 20
Utility
Methods of Treating And/or Preventing Psoriasis
29 Sep 22
Johnson Yiu-Nam LAU, Wing Kai CHAN, Min-Fun Rudolf KWAN
Filed: 5 Jun 20
Utility
Therapeutic combinations of orally administered docetaxel and a P-gp inhibitor for the treatment of cancer
19 Jul 22
The present disclosure provides pharmaceutical combinations of orally administered docetaxel and a P-gp inhibitor.
Min-Fun Rudolf Kwan, E. Douglas Kramer, David Lawrence Cutler, Johnson Yiu-Nam Lau, Wing Kai Chan
Filed: 29 Oct 20
Utility
Pharmaceutical Compositions for Modulating a Kinase Cascade and Methods of Use Thereof
26 May 22
The invention relates to a pharmaceutical composition comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
David G. Hangauer, JR.
Filed: 29 Sep 21
Utility
Biaryl Compositions In Combination with Tamoxifen and Methods for Modulating a Kinase Cascade
21 Apr 22
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
David G. HANGAUER, JR.
Filed: 31 Aug 21
Utility
Solid Forms of 2-(5-(4-(2-MORPHOLINOETHOXY)PHENYL)PYRIDIN-2-YL)-N-BENZYLACETAMIDE
31 Mar 22
The present application provides solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide, and methods of preparing and using the same for the treatment of a cell proliferative disorder in which a tyrosine kinase plays a role.
Michael P. SMOLINSKI
Filed: 9 Dec 21
Utility
Solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-n- benzylacetamide
25 Jan 22
The present application provides solid forms of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide, and methods of preparing and using the same for the treatment of a cell proliferative disorder in which a tyrosine kinase plays a role.
Michael P. Smolinski
Filed: 27 Apr 20
Utility
Biaryl Piperidine Amide Compounds and Methods of Use Thereof
11 Nov 21
The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.
Michael P. SMOLINSKI, Sameer URGAONKAR, James Lindsay CLEMENTS, David G. HANGAUER, JR.
Filed: 8 Dec 20
Utility
Therapeutic Combinations of Orally Administered Docetaxel and a P-GP Inhibitor for the Treatment of Cancer
23 Sep 21
The present disclosure provides pharmaceutical combinations of orally administered docetaxel and a P-gp inhibitor.
Min-Fun Rudolf KWAN, E. Douglas KRAMER, David Lawrence CUTLER, Johnson Yiu-Nam LAU, Wing Kai CHAN
Filed: 29 Oct 20
Utility
Biaryl Compositions and Methods for Modulating a Kinase Cascade
19 Aug 21
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
David G. HANGAUER, JR.
Filed: 19 Jan 21
Utility
Composition and Methods for Modulating a Kinase Cascade
15 Jul 21
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
David G. HANGAUER, Jr.
Filed: 24 Aug 20
Utility
Biaryl Compositions and Methods for Modulating a Kinase Cascade
1 Jul 21
The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.
Michael P. SMOLINSKI, Nader N. NASIEF ABDEL SAYED, David G. HANGAUER, JR.
Filed: 1 Mar 21
Utility
Compositions for Modulating a Kinase Cascade and Methods of Use Thereof
1 Jul 21
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts.
David G. HANGAUER, JR., Debasis PATRA, Jeremy A. CODY, Grant J. PALMER, Paul K. ISBESTER, Jonathon SALSBURY
Filed: 17 Mar 21
Utility
Pharmaceutical Compositions of Ramelteon and Methods of Use Thereof
22 Apr 21
The present invention relates to pharmaceutical compositions of ramelteon and methods of use thereof.
Yanfeng WANG, Liang XU, Juan CHEN, Benjamin Tak Kwong LEE
Filed: 12 Jul 18
Utility
Biaryl compositions and methods for modulating a kinase cascade
13 Apr 21
The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.
Michael P. Smolinski, Nader N. Nasief Abdel-Sayed, David G. Hangauer, Jr.
Filed: 26 Dec 18
Utility
Compositions and Methods for Treating Hyperproliferative Skin Disorders
11 Feb 21
Compositions and methods are provided that are effective in treating skin hyperproliferative disorders.
Johnson Yiu-Nam Lau, Alissa Rae Verone-Boyle, Chun-Ho Wong, Yahao Bu, Murray John Cutler, Krista Elizabeth Belko, Min-Fun Rudolf Kwan
Filed: 6 Mar 19