33 patents
Utility
Compositions and methods of treatment with amniotic fluid
9 Jan 24
The present disclosure provides compositions composed of amniotic fluid and/or modified amniotic fluid, a pharmaceutically acceptable carrier, and optionally a placental tissue graft, micronized placental tissue components, or extracts derived therefrom.
Thomas J. Koob, Michelle Massee
Filed: 27 May 21
Utility
Placental tissue grafts and improved methods of preparing and using the same
12 Sep 23
Described herein are tissue grafts derived from the placenta.
John Daniel, Randall Spencer, John Russo, Robert Tofe
Filed: 14 Dec 20
Utility
Non-surgical, localized delivery of compositions for placental growth factors
4 Jul 23
Described herewith are compositions comprising placental growth factors and methods for non-surgical, localized delivery thereof.
Thomas J. Koob, Rebeccah J. C. Brown
Filed: 10 Dec 19
Utility
Methods for treating cardiac conditions
16 May 23
Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
Thomas J. Koob, Hubbard Frank Burrows, III
Filed: 15 Jan 21
Utility
Tissue grafts composed of micronized placental tissue and methods of making and using the same
21 Mar 23
Described herein are dehydrated, laminated tissue grafts composed of two or more membrane layers of an amnion membrane, a chorion membrane, a Wharton's jelly, or an intermediate tissue layer, where a layer of micronized placental tissue is interposed between two of the layers.
Thomas J. Koob, John Daniel, Randall Spencer
Filed: 26 Mar 18
Utility
Laminated tissue grafts composed of Wharton's jelly and methods of making and using the same
14 Mar 23
Described herein are tissue grafts derived from the placenta with improved physical and biological properties.
Brenda S. Morse, Somaly Sith, Randall Spencer, John Daniel, Robert Tofe
Filed: 23 May 19
Utility
Methods of making collagen fiber medical constructs and related medical constructs, including patches
28 Feb 23
Implantable medical constructs formed by winding using winding support structures that can be flexible and can be integrated into the medical construct with biocompatible fiber(s) and/or yarn(s) and at least one continuous length collagen fiber.
Thomas J. Koob
Filed: 13 May 19
Utility
Collagen constructs and methods of making the same
21 Feb 23
The present disclosure describes a medical construct.
Chen-rei Wan, Thomas J. Koob, Kirk Joseph Naizer
Filed: 7 Aug 19
Utility
Placental tissue grafts and methods of preparing and using the same
22 Nov 22
A method for preparing placenta membrane tissue grafts for medical use, includes obtaining a placenta from a subject, cleaning the placenta, separating the chorion tissue from the amniotic membrane, mounting a selected layer of either the chorion tissue or the amniotic membrane onto a drying fixture, dehydrating the selected layer on the drying fixture, and cutting the selected layer into a plurality of tissue grafts.
John Daniel
Filed: 20 Feb 17
Utility
Isolated placental stem cell recruiting factors
15 Nov 22
Described herein are compositions and methods of using placental stem cell recruiting factors, more specifically, isolated placental stem cell recruiting factors.
Thomas J. Koob, Rebeccah J. C. Brown
Filed: 18 Feb 19
Utility
Placental tissue component compositions for treatment of skin defects and methods using same
26 Jul 22
The present disclosure provides methods of treating defects such as wrinkles or scars via a subdermal injection of placental tissue components.
Rick LeVaughn, Sivakkumar Arjunon, Olivia Taylor
Filed: 30 Nov 20
Utility
Molded placental tissue compositions and methods of making and using the same
19 Jul 22
Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof.
Thomas J. Koob, Guilhem Denoziere, Rebeccah J. C. Brown
Filed: 21 May 18
Utility
Placental tissue grafts modified with a cross-linking agent and methods of making and using the same
24 May 22
Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in wound healing applications.
John Daniel, Randall Spencer, Brenda Morse, Thomas J. Koob, Somaly Sith
Filed: 15 Mar 13
Utility
Micronized placental tissue compositions and methods of making and using the same
1 Feb 22
Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof.
Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
Filed: 18 Oct 18
Utility
Micronized placental tissue compositions and methods of making and using the same
11 Jan 22
Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof.
Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
Filed: 18 Oct 18
Utility
Micronized placental tissue compositions and methods of making and using the same
31 Aug 21
Described herein are compositions composed of micronized placental components and pharmaceutical compositions thereof.
Brenda S. Morse, Somaly Sith, Randall Spencer, Steven Ray, John Daniel, Robert Tofe
Filed: 24 Jul 19
Utility
Placental tissue composition for for treating cardiac tissue damage
11 May 21
Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
Thomas J. Koob, Hubbard Frank Burrows, III
Filed: 10 Sep 18
Utility
Compositions and methods of treatment with amniotic fluid
30 Mar 21
The present disclosure provides compositions composed of amniotic fluid and/or modified amniotic fluid, a pharmaceutically acceptable carrier, and optionally a placental tissue graft, micronized placental tissue components, or extracts derived therefrom.
Thomas J. Koob, Michelle Massee
Filed: 23 Mar 17
Utility
Synthetic collagen threads for cosmetic uses including skin wrinkle treatments and associated methods
2 Mar 21
Cosmetic threads for reducing wrinkle size include at least one synthetic collagen fiber that wells after placement under the skin.
Rebeccah Brown, Thomas J. Koob
Filed: 7 Jun 17
Utility
Placental tissue grafts and improved methods of preparing and using the same
28 Dec 20
Described herein are tissue grafts derived from the placenta.
John Daniel, Randall Spencer, John Russo, Robert Tofe
Filed: 25 Sep 17