2 patents
Utility
Combination immunotherapy for treatment of triple-negative breast cancer
31 Jan 23
The present invention concerns a method for treating triple-negative breast cancer (TNBC) in an individual, and/or for inducing an immune response to HER2/neu in an individual with a triple-negative breast cancer expressing low levels of HER2/neu, the method comprising administering to the individual: (a) an effective amount of trastuzumab, or derivative thereof; and (b) an effective amount of nelipepimut-S, or variant thereof, optionally with an immunological adjuvant.
George E. Peoples, Angelos M. Stergiou, Nicholas J. Sarlis
Filed: 19 Oct 19
Utility
Multi-valent Immunotherapy Composition and Methods of Use for Treating WT1-POSITIVE Cancers
2 Jun 22
This invention provides methods of treating, reducing the incidence of, and inducing immune responses to a WT1-expressing cancer, by administering a combination of WT1 peptides including each of: YMFPNAPYL, RSDELVRHHNMHQRNMTKL, PGCNKRYFKLSHLQMHSRKHTG, SGQAYMFPNAPYLPSCLES, NLMNLGATL, WNLMNLGATLKGVAA, and WNYMNLGATLKGVAA, or cytotoxic T cells induced by the combination of WT1 peptides.
ANGELOS M. STERGIOU, NICHOLAS J. SARLIS, DAVID A. SCHEINBERG, TAO DAO
Filed: 10 Apr 20
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