88 patents
Utility
Methods, systems, and devices for treating nerve spasticity
9 Jan 24
A method in which a nerve associated with a spasticity in a limb of a patient may be identified.
Jwala Karnik, John Allison, Clint Carnell
Filed: 7 Jan 22
Utility
Cryogenic needle with freeze zone regulation
2 Jan 24
A cryogenic needle of a cryogenic system is coupled to a heater.
Michael Fourkas, Ronald Williams, John Allison, Jesse Rosen
Filed: 28 Jan 19
Utility
Manufacturing of bupivacaine multivesicular liposomes
21 Nov 23
Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.
Jeffrey S. Hall, David J. Turnbull, John J. Grigsby, Jr., Soroush M. Ardekani, Kathleen D. A. Los
Filed: 13 Apr 22
Utility
Manufacturing of bupivacaine multivesicular liposomes
21 Nov 23
Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.
Jeffrey S. Hall, David J. Turnbull, John J. Grigsby, Jr., Soroush M. Ardekani, Kathleen D. A. Los
Filed: 13 Apr 22
Utility
Treatment of pain by administration of sustained-release liposomal anesthetic compositions
21 Nov 23
Kathy Los, Vladimir Kharitonov
Filed: 3 Oct 22
Utility
Treatment of hip pain with sustained-release liposomal anesthetic compositions
21 Nov 23
In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.
Jonathan H. Slonin, Roy Winston, Stan Dysart
Filed: 2 Mar 22
Utility
Treatment of hip pain with sustained-release liposomal anesthetic compositions
14 Nov 23
In some embodiments provided herein is a method of treating hip pain in a subject, the method comprising administering into the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.
Jonathan H. Slonin, Roy Winston, Stan Dysart
Filed: 17 May 22
Utility
Display Device and Interfaces for Cryogenic Devices
2 Nov 23
The disclosure describes a cryogenic device with a display device for displaying one of a plurality of user-interfaces associated with a plurality of cryogenic device states.
Eric Theodore Johansson, Jeff Gamelsky, Pierre-Andre Mugnier
Filed: 10 Jul 23
Utility
Stabilizing pressure in cryogenic devices
10 Oct 23
Methods for stabilizing pressure within a cryogenic device include receiving a flow rate value corresponding to an expected average mass flow rate of a cryogen through a needle probe of the cryogenic device during a cryotherapy treatment cycle; determining, based on the flow rate value, a target heater power to be applied to a heater associated with the cryogenic device for a treatment cycle, wherein the heater is configured to heat the cryogen; receiving an input for the treatment cycle; causing the cryogen to flow for a period of time toward the needle probe in response to the input; and apply the target heater power to the heater during the treatment cycle so as to heat the cryogen and stabilize pressure within the cryogenic device.
Eric Theodore Johansson
Filed: 24 Nov 20
Utility
Manufacturing of Bupivacaine Multivesicular Liposomes
28 Sep 23
Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.
Jeffrey S. Hall, David J. Turnbull, John J. Grigsby, JR., Soroush M. Ardekani, Kathleen D. A. Los
Filed: 30 May 23
Utility
Manufacturing of Bupivacaine Multivesicular Liposomes
21 Sep 23
Embodiments of the present application relate to batches of bupivacaine multivesicular liposomes (MVLs) prepared by a commercial manufacturing process using independently operating dual tangential flow filtration modules.
Jeffrey S. Hall, David J. Turnbull, John J. Grigsby, JR., Soroush M. Ardekani, Kathleen D.A. Los
Filed: 30 May 23
Utility
Treatment of pain by subarachnoid administration of sustained-release liposomal anesthetic compositions
19 Sep 23
In some embodiments provided herein is a method of treating pain, the method comprising injecting into the subarachnoid space of the subject a pharmaceutical composition comprising: a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and b) an aqueous phase comprising bupivacaine phosphate, wherein the aqueous phase is encapsulated within the multivesicular liposome.
Roy Winston, Kathy Los, Vladimir Kharitonov
Filed: 3 Oct 22
Utility
Secure Cryosurgical Treatment System
7 Sep 23
A method for cryogenically treating tissue.
Corydon A. Hinton, Kyler Mikhail Connelly, Bijy Zachariah, Jesse Rosen
Filed: 12 May 23
Utility
Cryogenic Therapy Systems and Methods
7 Sep 23
A method of interrupting sympathetic stimulation to the cardiovascular system of a patient in need thereof includes navigating a probe of a hand-held cryogenic therapy apparatus to a stellate ganglion or an autonomic tissue area peripheral to the stellate ganglion of the patient, the probe including a needle configured to produce a cooling zone for focused cryogenic therapy, aligning the needle with one or more desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion, and producing the cooling zone to provide cryogenic therapy to the desired nerves of the stellate ganglion or the autonomic tissue area peripheral to the stellate ganglion at a temperature sufficient to cause axonotmesis of the nerves.
John Spranger, Roy Winston, Jared Ham, Jonathan Slonin
Filed: 21 Feb 23
Utility
Uses of Bupivacaine Multivesicular Liposomes As Stellate Ganglion Block
7 Sep 23
Embodiments of the present disclosure relate to the use of bupivacaine multivesicular liposomes (MVLs) as stellate ganglion block (SGB) for treating or ameliorating various diseases and conditions, including but not limited to cardiac electrical storm or cardiac arrythmia/dysrhythmia following heart surgery.
John Spranger, Roy Winston, Jared Ham, Jonathan Slonin
Filed: 21 Feb 23
Design
Cryogenic device
15 Aug 23
Jeffrey N. Gamelsky, Pierre-Andre Mugnier, Eric T. Johansson, Andrew Huffmaster
Filed: 26 Apr 21
Utility
Compositions of Bupivacaine Multivesicular Liposomes
10 Aug 23
Embodiments of the present application relate to compositions of multivesicular liposomes (MVLs) and manufacturing processes for making bupivacaine MVLs.
Jeffrey S. Hall, David J. Turnbull, John J. Grigsby, JR., Soroush M. Ardekani, Kathleen D. A. Los
Filed: 14 Sep 22
Utility
Cryogenic Enhancement of Joint Function, Alleviation of Joint Stiffness and/or Alleviation of Pain Associated With Osteoarthritis
13 Jul 23
Embodiments include a cryogenic device for alleviating pain by cryogenically treating a nerve, the cryogenic device including a handpiece; a needle coupled to a distal end of the handpiece, the needle including a needle lumen, the needle being configured for insertion into a skin of a patient along an insertion axis at a site laterally displaced from a treatment zone proximate to the nerve.
Jwala Karnik, Jason Reynolds, John Allison, Clint Carnell
Filed: 22 Mar 23
Utility
Secure cryosurgical treatment system
4 Jul 23
A method for cryogenically treating tissue.
Corydon A. Hinton, Kyler Mikhail Connelly, Bijy Zachariah, Jesse Rosen
Filed: 6 Nov 20
Design
Dock for a cryogenic device
27 Jun 23
Jeffrey N. Gamelsky, Pierre-Andre Mugnier, Eric T. Johansson, Andrew Huffmaster
Filed: 23 Apr 21