33 patents
Page 2 of 2
Utility
Bispecific CD123 x CD3 Diabodies for the Treatment of Hematologic Malignancies
23 Dec 21
The present invention is directed to a method of treating a hematologic malignancy such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), including hematologic malignancies that are refractive to chemotherapeutic and/or hypomethylating agents.
Jan Kenneth Davidson, Sara Church, Sergio Rutella
Filed: 29 Oct 19
Utility
Molecular Gene Signatures and Methods of Using Same
25 Nov 21
The invention provides methods of using expression levels of one or more cell gene signatures and/or combinations of cell gene signatures as selection criteria for selecting a patient having a cancer for treatment with a therapeutic.
Sarah WARREN, Patrick DANAHER
Filed: 20 May 19
Utility
Methods and apparatuses for gene purification and imaging
24 Aug 21
The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging.
Dwayne Dunaway, Rustem Khafizov, Qian Mei, Lucas Dennis, Michael Krouse, Joseph M. Beechem, Isaac Sprague
Filed: 11 Feb 19
Utility
Gene Expression Assay for Measurement of Dna Mismatch Repair Deficiency
1 Jul 21
The present disclosure relates to methods using gene expression measurements to identify mismatch repair deficiency, microsatellite instability and hypermutation in a subject.
Patrick DANAHER, Sarah WARREN
Filed: 2 Nov 20
Utility
Obinutuzumab Treatment of a DLBCL Patient Subgroup
7 Oct 20
The present invention relates to obinutuzumab (or its functional equivalents) for use in the treatment of a particular biomarker-defined DLBCL patient and a novel DLBCL patient subgroup, respectively.
Mikkel Zahle OESTERGAARD
Filed: 5 Feb 20
Utility
Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
4 May 20
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Joseph M. Beechem, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder, Kristina Sorg, Gordon B. Mills
Filed: 14 Jul 16
Utility
Simultaneous Quantification of a Plurality of Proteins In a User-defined Region of a Cross-sectioned Tissue
5 Feb 20
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Joseph M. BEECHEM, Gordon B. MILLS, Charles WARREN, Chris MERRITT, Jaemyeong JUNG, Dwayne L. DUNAWAY, Scott CROWDER
Filed: 7 Oct 19
Utility
Simultaneous Quantification of Gene Expression In a User-defined Region of a Cross-sectioned Tissue
5 Feb 20
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Joseph M. BEECHEM, Charles WARREN, Chris MERRITT, Jaemyeong JUNG, Dwayne L. DUNAWAY, Scott CROWDER, Kristina SORG, Gordon B. MILLS
Filed: 7 Oct 19
Utility
Enzyme- and Amplification-free Sequencing
8 Jan 20
The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplification-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate.
Joseph M. BEECHEM, Rustem KHAFIZOV
Filed: 31 Jul 19
Utility
Chemical Compositions and Methods of Using Same
25 Dec 19
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
Dwayne L. DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG
Filed: 3 Sep 19
Utility
Simultaneous quantification of a plurality of proteins in a user-defined region of a cross-sectioned tissue
9 Dec 19
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Joseph M. Beechem, Gordon Mills, Charles Warren, Chris Merritt, Jaemyeong Jung, Dwayne L. Dunaway, Scott Crowder
Filed: 14 Jul 16
Utility
Chemical Compositions and Methods of Using Same
13 Nov 19
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
Dwayne DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG, Matthew WALSH, Gavin MEREDITH, Mark MCELWAIN, Peter Skene, Cassandra Burke
Filed: 13 May 19
Utility
Methods and Apparatuses for Gene Purification and Imaging
16 Oct 19
The present disclosure is directed to systems, devices and methods for nucleic acid or protein purification and imaging.
Dwayne Dunaway, Rustem Khafizov, Qian Mei, Lucas Dennis, Michael Krouse, Joseph M. Beechem, Isaac Sprague
Filed: 10 Feb 19