23 patents
Utility
Methods, Systems and Devices for Processing Sequence Data
18 Jan 24
Embodiments of the present disclosure are directed to systems, apparatuses, devices and methods for processing sequencing data for determining the identity of DNA fragments from a plurality of reads contained in a sequencing data file.
Peter ASKOVICH
Filed: 8 Oct 21
Utility
Chemical Compositions and Methods of Using the Same
16 Nov 23
The present disclosure provides compositions and methods for the detection and identification of target nucleic acids within a tissue sample using fluorescent probes, wherein the probes comprise a target-binding domain and a barcode domain.
Shanshan HE, Dwayne L. DUNAWAY, Isabel LEE, Dae KIM, Joseph M. BEECHEM, Lidan WU
Filed: 16 Sep 21
Utility
Obinutuzumab Treatment of a DLBCL Patient Subgroup
2 Nov 23
The present invention relates to obinutuzumab (or its functional equivalents) for use in the treatment of a particular biomarker-defined DLBCL patient and a novel DLBCL patient subgroup, respectively.
Mikkel Zahle OESTERGAARD
Filed: 2 Feb 23
Utility
Chemical Compositions and Methods of Using Same
17 Aug 23
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
Dwayne L. DUNAWAY, Elizabeth A. Manrao, Joseph M. Beechem, Rustem Khafizov, Sanghamithra Korukonda, Yi Deng, Dae Kim, Mark Gregory, Margaret Hoang
Filed: 7 Mar 23
Utility
Compositions and Methods for In Situ Single Cell Analysis Using Enzymatic Nucleic Acid Extension
27 Jul 23
The present disclosure is based in part on probes, compositions, methods, and kits for simultaneous, multiplexed spatial detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.--
Jonathan CHENG, Dwayne DUNAWAY, Mark GREGORY, Jaemyeong JUNG, Rustem KHAFIZOV, Dae KIM, Evan Paul PERILLO, Tushar RANE, Lidan WU
Filed: 17 Jun 21
Utility
Chemical Compositions and Methods of Using Same
13 Jul 23
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
Dwayne DUNAWAY, Elizabeth A. MANRAO, Joseph M. BEECHEM, Rustem KHAFIZOV, Sanghamithra KORUKONDA, Yi DENG, Dae KIM, Mark GREGORY, Margaret HOANG, Matthew WALSH, Gavin MEREDITH, Mark MCELWAIN, Peter SKENE, Cassandra Burke
Filed: 21 Dec 22
Utility
Chemical Compositions and Methods of Use
25 May 23
The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplification-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate.
Joseph M. BEECHEM, Rustem KHAFIZOV
Filed: 29 Jul 22
Utility
Bioassay Substrate Having Fiducial Domains and Methods of Manufacture Thereof
18 May 23
Embodiments of the present disclosure are directed to an array substrate which can be used in nucleic acid sequencing, which includes a plurality of fiducial domains (FDs).
Camelia RUSU, Huawen WU, Joshua Dale BAKER, Jeffrey MARKS, Wesley C. CHANG, Dae KIM
Filed: 23 Apr 21
Utility
Chemical Compositions and Uses Thereof
8 Sep 22
The present disclosure relates to chemical compositions, kits, and apparatuses and methods for using these compositions, kits and apparatuses in various assays.
Rustem KHAFIZOV, Dwayne DUNAWAY, Mark GREGORY
Filed: 7 Mar 22
Utility
Biomolecular Probes and Methods of Detecting Gene and Protein Expression
14 Jul 22
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
Joseph M. BEECHEM, Dae KIM, Margaret HOANG, Mark GREGORY, Erin PIAZZA, Denise ZHOU
Filed: 28 Mar 22
Utility
Methods, Apparatuses, Systems and Devices for Mobile Digital Spatial Profiling of Pathological Specimens
10 Mar 22
Embodiments of the present disclosure are directed to a compact, mobile, digital spatial profiling (DSP) system, and associated apparatuses, devices and methods, which are configured to image one or more regions-of-interest (ROIs), and then using UV light to cleave, for example, oligos off antibodies in one or more ROIs (“photocleaving”), and collect the photocleaved oligos for later hybridization and counting.
Joseph M. BEECHEM, Dwayne DUNAWAY, Jaemyeong JUNG, Peter G. SCHULTZ, Eliot SOSIN, Grant TREMEL
Filed: 20 Dec 19
Utility
Chemical Compositions and Uses Thereof
30 Dec 21
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
Joseph M. BEECHEM, Dae KIM, Margaret HOANG, Mark GREGORY, Erin PIAZZA, Denise ZHOU
Filed: 16 Sep 21
Utility
Chemical Compositions and Uses Thereof
30 Dec 21
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell that are adaptable for use with existing sequencing technologies.
Joseph M. BEECHEM, Dae KIM, Margaret HOANG, Mark GREGORY, Erin PIAZZA, Denise ZHOU
Filed: 16 Sep 21
Utility
Bispecific CD123 x CD3 Diabodies for the Treatment of Hematologic Malignancies
23 Dec 21
The present invention is directed to a method of treating a hematologic malignancy such as acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), including hematologic malignancies that are refractive to chemotherapeutic and/or hypomethylating agents.
Jan Kenneth Davidson, Sara Church, Sergio Rutella
Filed: 29 Oct 19
Utility
Molecular Gene Signatures and Methods of Using Same
25 Nov 21
The invention provides methods of using expression levels of one or more cell gene signatures and/or combinations of cell gene signatures as selection criteria for selecting a patient having a cancer for treatment with a therapeutic.
Sarah WARREN, Patrick DANAHER
Filed: 20 May 19
Utility
Gene Expression Assay for Measurement of Dna Mismatch Repair Deficiency
1 Jul 21
The present disclosure relates to methods using gene expression measurements to identify mismatch repair deficiency, microsatellite instability and hypermutation in a subject.
Patrick DANAHER, Sarah WARREN
Filed: 2 Nov 20
Utility
Obinutuzumab Treatment of a DLBCL Patient Subgroup
7 Oct 20
The present invention relates to obinutuzumab (or its functional equivalents) for use in the treatment of a particular biomarker-defined DLBCL patient and a novel DLBCL patient subgroup, respectively.
Mikkel Zahle OESTERGAARD
Filed: 5 Feb 20
Utility
Simultaneous Quantification of Gene Expression In a User-defined Region of a Cross-sectioned Tissue
5 Feb 20
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein and/or nucleic acid expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Joseph M. BEECHEM, Charles WARREN, Chris MERRITT, Jaemyeong JUNG, Dwayne L. DUNAWAY, Scott CROWDER, Kristina SORG, Gordon B. MILLS
Filed: 7 Oct 19
Utility
Simultaneous Quantification of a Plurality of Proteins In a User-defined Region of a Cross-sectioned Tissue
5 Feb 20
The present invention relates to, among other things, probes, compositions, methods, and kits for simultaneous, multiplexed detection and quantification of protein expression in a user-defined region of a tissue, user-defined cell, and/or user-defined subcellular structure within a cell.
Joseph M. BEECHEM, Gordon B. MILLS, Charles WARREN, Chris MERRITT, Jaemyeong JUNG, Dwayne L. DUNAWAY, Scott CROWDER
Filed: 7 Oct 19
Utility
Enzyme- and Amplification-free Sequencing
8 Jan 20
The present invention relates to sequencing probes, methods, kits, and apparatuses that provide enzyme-free, amplification-free, and library-free nucleic acid sequencing that has long-read-lengths and with low error rate.
Joseph M. BEECHEM, Rustem KHAFIZOV
Filed: 31 Jul 19