45 patents
Utility
Inhibition and Reversion of Chronic Obstructive Pulmonary Disease (Copd) by Endothelial Cell Regeneration
16 Nov 23
Disclosed are means, treatment methods, and compositions of matter useful for prevention and/or reversion of chronic obstructive pulmonary disease (COPD).
Thomas E. ICHIM, Timothy G. DIXON, Zeeshan PIRACHA, James VELTMEYER
Filed: 11 May 23
Utility
Methods of Determining Risk of Suicide by Immunological Assessment
19 Oct 23
Disclosed are means and methods of identifying risk of suicide and/or suicidal ideation by assessment of immunologically related cytokines and cells.
Thomas E. ICHIM, Timothy G. DIXON, Kalina O'CONNOR, Famela RAMOS, James VELTMEYER, Wais KAIHANI
Filed: 23 Aug 21
Utility
Treatment of COVID-19 Associated Cognitive Dysfunction by Nutraceutical Preparations
28 Sep 23
Disclosed are means and methods of treating cognitive dysfunction associated with COVID-19 and/or other associated with inflammatory conditions.
Thomas ICHIM, Timothy G. DIXON
Filed: 7 Feb 23
Utility
Upregulation of therapeutic T regulatory cells and suppression of suicidal ideations in response to inflammation by administration of nutraceutical compositions alone or combined with minocycline
19 Sep 23
Disclosed are compositions of matter, treatments and protocols useful for induction of T regulatory cells in response to inflammation, as well as inhibition of suicidal ideations and/or neuroinflammation.
Thomas E. Ichim, Timothy G. Dixon, Kalina O'Connor
Filed: 30 Aug 21
Utility
Treatment of Trauma Associated Cognitive Dysfunction Using Mesenchymal Stem Cell Apoptotic Bodies and Compositions Thereof
7 Sep 23
Disclosed are means, treatments and compositions of matter useful for treatment of chemotherapy/radiotherapy associated cognitive dysfunction.
Santosh KESARI, Thomas ICHIM, Timothy Dixon, Kalina O'CONNOR, Wais KAIHANI, Duncan HUNTER
Filed: 6 Mar 23
Utility
Umbilical Cord Derived Regenerative and Immune Modulatory Stem Cell Populations
20 Jul 23
The present invention provides universal donor cellular populations derived from umbilical cords possessing ability to elicit immune modulation and evoke regeneration when administered into a mammalian host.
Thomas E. Ichim, Timothy G. Dixon
Filed: 2 Dec 22
Utility
Reduction of Neutrophil Extracellular Trap Formation by Mesenchymal Stem Cells and Their Exosomes
6 Apr 23
Disclosed are methods of reducing lung inflammation in acute respiratory distress syndrome elicited by various factors such as COVID-19 infection by reduction of neutrophil extracellular trap formation through administration of mesenchymal stem cells and/or exosomes thereof.
Thomas E. Ichim, Famela Ramos, James Veltmeyer, Timothy G. Dixon, Feng Lin, Wais Kaihani
Filed: 4 Oct 22
Utility
Stimulation of Mesenchymal Stem Cell Therapeutic Activities by T Regulatory Cells
23 Mar 23
Disclosed are novel means of enhancing mesenchymal stem cell regenerative activities including, intra alia, production from pulmonary leakage and suppression of scar tissue formation by co-administration with T regulatory cells.
Thomas E. Ichim, Famela Ramos, James Veltmeyer, Timothy G. Dixon, Feng Lin, Kalina O'Connor
Filed: 22 Sep 22
Utility
Ivermectin Compositions for Treatment of COVID-19
16 Mar 23
Disclosed are novel mechanisms of action of ivermectin therapy as related to treatment of COVID-19 and means of augmenting therapeutic activities by co-administration with one or more of the following: pterostilbene, thymoquinone, epigallocatechin-3-gallate, and sulforaphane.
Thomas E. Ichim, Famela Ramos, James Veltmeyer, Timothy G. Dixon, Feng Lin, Wais Kaihani
Filed: 13 Sep 22
Utility
Enhancement of Umbilical Cord Mesenchymal Stem Cell Therapeutic Activity by Stimulators of T Regulatory Cells And/or Cells Expressing CD73
23 Feb 23
Disclosed are means, compositions of matter and protocols useful for treatment of COVID-19 and/or other inflammatory pathologies through stimulation of T regulatory cells and/or T cells expressing CD73 using administration of umbilical cord derived mesenchymal stem cells such as JadiCells.
Thomas C. ICHIM, Famela RAMOS, James VELTMEYER, Timothy G. DIXON, Wais KAIHANI
Filed: 18 Aug 22
Utility
Umbilical Cord Mesenchymal Stem Cells for Treatment of Chronic Obstructive Pulmonary Disease and Lung Degeneration
23 Feb 23
The invention discloses means of treating lung degenerative diseases including chronic obstructive pulmonary disease (CODP) using umbilical cord mesenchymal stem cells such as JadiCells alone, and/or using said cells under conditions that are activated in order to endow enhanced regenerative activity.
Thomas E. ICHIM, Timothy G. DIXON, James VELTMEYER, Famela RAMOS
Filed: 23 Aug 22
Utility
Induction of Neurogenesis Using Umbilical Cord Derived Mesenchymal Stem Cells and Derivatives Thereof
16 Feb 23
Disclosed are means, compositions of matter and protocols useful for treatment of neurological dysfunctions through stimulation of adult neurogenesis using administration of umbilical cord derived mesenchymal stem cells such as JadiCells.
Thomas E. ICHIM, Timothy G. DIXON, Amit N. PATEL, Famela RAMOS, James VELTMEYER
Filed: 11 Aug 22
Utility
Treatment of Parkinson's Disease by Immune Modulation and Regenerative Means
12 Jan 23
Disclosed are means, methods and compositions of matter for treatment Parkinson's Disease through concurrent immune modulation and regenerative means.
Thomas E. Ichim, Timothy G. Dixon, James Veltmeyer, Kalina O'Connor
Filed: 6 Jul 22
Utility
Compositions Capable of Stimulating Immunity Towards Tumor Blood Vessels
22 Dec 22
Disclosed are novel means, protocols, and compositions of matter for eliciting an immune response against blood vessels supplying neoplastic tissue.
Thomas E. Ichim, Famela Ramos, James Veltmeyer, Timothy G. Dixon, Feng Lin
Filed: 19 May 22
Utility
Treatment of COVID-19 Lung Injury Using Umbilical Cord Plasma Based Compositions
15 Dec 22
Disclosed are means, methods and compositions of matter useful for treatment of lung inflammation associated with viral and bacterial infections, as well as with systemic inflammation, through administration of umbilical cord blood derived plasma-based compositions.
James Veltmeyer, Thomas E. Ichim, Timothy G. Dixon
Filed: 9 Jun 21
Utility
Immunotherapies for Targeting of Tumor Vasculature
24 Nov 22
Disclosed are novel means, protocols, and compositions of matter for creating targeted immune responses and/or induction of immunological memory towards the tumor vasculature.
Thomas E. Ichim, Famela Ramos, James Veltmeyer, Timothy G. Dixon, Feng Lin, Wais Kaihani
Filed: 19 May 22
Utility
Lithium As a Monotherapy And/or Stem Cell Adjuvant Therapy for Pulmonary Fibrosis
24 Nov 22
Disclosed are compositions of matter, therapeutics, and protocols useful for reduction and/or reversion of pulmonary fibrosis.
Thomas E. Ichim, Timothy G. Dixon, Wals Kaihani, Famela Ramos, James Veltmeyer
Filed: 19 May 22
Utility
Neuroprotection and neuroregeneration by pterostilbene and compositions thereof
22 Nov 22
Disclosed are means, compositions of matter, and protocols useful for neuroprotection and neuroregeneration.
Thomas E. Ichim, Timothy G. Dixon, James Veltmeyer
Filed: 28 Jul 21
Utility
Treatment of Major Depressive Disorder by Low Dose INTERLEUKIN-2
17 Nov 22
Disclosed are methods, compositions of matter, and protocols useful for treatment of major depressive disorder through administration of low dose interleukin-2 at a concentration and/or frequency sufficient to increase expansion of T regulatory cell numbers and/or enhancement of T regulatory cell activity.
Thomas E. ICHIM, Timothy G. DIXON, Kalina O'CONNOR, Wais KAIHANI
Filed: 13 May 22
Utility
Amelioration and Treatment of Opioid Addiction
13 Oct 22
Disclosed are compositions of matter, protocols and treatment means for reducing and/or preventing opioid addiction.
Thomas E. Ichim, Timothy G. Dixon, James Veltmeyer, Kalina O'Connor
Filed: 13 Apr 22