1063 patents
Page 3 of 54
Utility
Treatment of LAG-3 positive tumors
7 Nov 23
The invention provides a method of treating a tumor in a human patient comprising (i) identifying a patient as having a LAG-3 positive tumor and (ii) administering to the patient a PD-1 pathway inhibitor, a combination of a PD1 pathway inhibitor and an immune checkpoint inhibitor, a combination of a LAG-3 inhibitor and a PD-1 pathway inhibitor, or an anti-CTLA4 antibody.
James Novotny, Jr., Nils Lonberg, Cyrus Hedvat, Raphael Clynes, Darren Locke, John P. Cogswell, Jeffrey Jackson, Christopher Harbison, Robin Edwards
Filed: 30 May 18
Utility
FGF-21 Conjugate Formulations
2 Nov 23
The present application provides pharmaceutical formulations comprising PEGylated FGF−21, e.g., a FGF-21 conjugate, and one or more stabilizers such as the chelator DPTA.
Thomas PALM, Mehrnaz KHOSSRAVI, Sanket PATKE
Filed: 7 Jan 21
Utility
Oxopyrrolidine FPR2 Agonists
2 Nov 23
Pravin Sudhakar Shirude, Chandrasekhar Reddy Rachamreddy, Amit Kumar Chattopadhyay, Balaji Seshadri, Vishweshwaraiah Baligar, Sudhakara Reddy Madduri, Ellen K. Kick, Nicholas R. Wurtz
Filed: 8 Jul 21
Utility
NLRP3 Modulators
2 Nov 23
Scott Hunter Watterson, Hua Gong, Kristin Williams, Ashvinikumar V. Gavai, Prasanna Sivaprakasam, Yong Zhang
Filed: 8 Jan 21
Utility
1H-PYRAZOLO[4,3-d]PYRIMIDINE COMPOUNDS AS TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS
2 Nov 23
Matthew COX, Naidu S. CHOWDARI, Ashvinikumar V. GAVAI, Sanjeev GANGWAR, Christine M. TARBY, Yam B. POUDEL, Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH
Filed: 26 Jan 21
Utility
Combinatorial drug delivery device
31 Oct 23
In one aspect, a combinatorial drug delivery device is provided for delivering a predetermined selection of drug components.
Martin John McLoughlin, Chester Larrow, Mariano Mumpower
Filed: 26 Oct 22
Utility
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
31 Oct 23
Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR).
Changyu Wang, Nils Lonberg, Alan J. Korman, Mark J. Selby, Mohan Srinivasan, Karla A. Henning, Michelle Minhua Han, Guodong Chen, Richard Huang, Indrani Chakraborty, Haichun Huang, Susan Wong, Huiming Li
Filed: 25 Oct 19
Utility
Plug-and-analyze Framework for Knowledge Base Construction
26 Oct 23
Provided herein are system, apparatus, device, method, and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for generating a knowledge base.
Octavian Florin FILOTI, Christian Joseph MERRILL, Mark SALACINSKI, Irene Yue-Ling PAK
Filed: 20 Apr 22
Utility
Treatment of Cancer with TOR Kinase Inhibitors
26 Oct 23
Provided herein are methods for treating or preventing triple negative breast cancer or hormone receptor positive breast cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having triple negative breast cancer or hormone receptor positive breast cancer.
Shuichan Xu, Kristen Mae Hege, Heather Raymon, Rama K. Narla
Filed: 28 Oct 22
Utility
Framework for Document Layout and Information Extraction
26 Oct 23
Provided herein are system, apparatus, device, method, and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for extracting data from a file.
Mark SALACINSKI, Christian Joseph Merrill, Octavian Florin Filoti, Irene Yue-Ling Pak
Filed: 20 Apr 22
Utility
Triazole N-Linked Carbamoyl Cyclohexyl Acids as LPA Antagonists
26 Oct 23
Yan Shi, Peter Tai Wah Cheng, Ying Wang, Jun Shi, Shiwei Tao, Jun Li, Lawrence J. Kennedy, Robert F. Kaltenbach, III, Hao Zhang, James R. Corte
Filed: 22 May 23
Utility
Uracil Derivatives As Mer-axl Inhibitors
26 Oct 23
The invention relates generally to compounds that are Mer-Ax1 inhibitors, pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.
Christine M. Tarby, Derek J. Norris, Julian C. Lo, Vijay T. Ahuja, Steven P. Seitz, Ashvinikumar V. Gavai, John S. Tokarski, Mohini Rajasagi, Michael Wichroski, Matthias Broekema
Filed: 2 May 19
Utility
Transforming Growth Factor Beta (Tgfbeta) Binding Agents and Uses Thereof
26 Oct 23
There are provided tetravalent TGFβ receptor-ectodomain based traps having a tailored isoform-specificity profile for neutralization of TGFβ ligands, and methods of use thereof in the treatment of diseases and conditions associated with TGFβ, particularly TGFβ1 and TGFβ3.
Maureen O’Connor, Gilles Tremblay, Jean-Francois Denis, Vannakambadi K. Ganesh
Filed: 11 Jun 21
Utility
Antagonistic CD40 monoclonal antibodies and uses thereof
24 Oct 23
The disclosure provides for antibodies that bind CD40, including a humanized antibody.
Aaron Yamniuk, Mary Struthers, Stanley R. Krystek, Jr., Akbar Nayeem, Ginger Rakestraw
Filed: 11 Feb 22
Utility
GSPT1 Compounds and Methods of Use of the Novel Compounds
19 Oct 23
Joshua Hansen, Mimi L. Quan
Filed: 13 Apr 23
Utility
Method of Treating an Autoimmune Disease with Antagonistic CD40 Monoclonal Antibodies
19 Oct 23
A method of treating an autoimmune disease such as Sjögren's Syndrome is provided.
Ying Ye, Urvi Aras, Nidhi Sharda, Mary Struthers, Karen Price, Ihab Girgis, Aberra Fura
Filed: 25 Aug 21
Utility
Sulfone pyridine alkyl amide-substituted heteroaryl compounds
17 Oct 23
Chunjian Liu, Michael G. Yang, Zili Xiao, Ling Chen, Ryan M. Moslin, John S. Tokarski, David S. Weinstein, Stephen T. Wrobleski
Filed: 28 Apr 21
Utility
TIM-3 antagonists for the treatment and diagnosis of cancers
17 Oct 23
Provided herein are methods for treating a subject afflicted with a cancer, comprising administering to the subject a TIM3 agonist (e.g., an anti-TIM3 antibody), alone or in conjunction with another immune checkpoint inhibitor (e.g., a PD-1 antagonist), wherein the subject is identified as having a high frequency of TIM3 positive cells (e.g., on the tumor infiltrating inflammatory cells) or soluble TIM3 in peripheral blood.
Anke Klippel, Laurence Celine Menard
Filed: 28 Aug 18
Reissue
Substituted nitrogen containing compounds
17 Oct 23
Navnath Dnyanoba Yadav, Rajeev S. Bhide, Rajesh Onkardas Bora, Prashantha Gunaga, Manoranjan Panda, Eldon Scott Priestley, Jeremy Richter
Filed: 23 Feb 21
Utility
Classifying pharmacovigilance documents using image analysis
17 Oct 23
Provided herein are system, apparatus, device, method, and/or computer program product embodiments, and/or combinations and sub-combinations thereof, for classifying a document using image analysis.
Sameen Mayur Desai
Filed: 11 Jun 21