1063 patents
Page 4 of 54
Utility
Inhibitors of Protein Tyrosine Phosphatase, Compositions, and Methods of Use
12 Oct 23
Haibo Liu, Laura Akullian D′Agostino, Shoshana L. Posy, Annapurna Pendri, Swanee E. Jacutin-Porte
Filed: 30 Jan 23
Utility
Antagonistic CD40 Monoclonal Antibodies and Uses Thereof
12 Oct 23
The disclosure provides for antibodies that bind CD40, including a humanized antibody and a chimeric antibody with different Fc domains.
Aaron Yamniuk, Mary Struthers, Suzanne J. Suchard
Filed: 10 Mar 23
Utility
Quinazolines As Potassium Ion Channel Inhibitors
12 Oct 23
James A. Johnson, John Lloyd, Heather Finlay, James Neels, Naveen Kumar Dhondi, Prashantha Gunaga, Abhisek Banerjee, Ashokkumar Adisechan
Filed: 24 Mar 23
Utility
Method of Making Protein
12 Oct 23
This disclosure provides a novel method of controlling the glycosylation profile of a protein during production.
Amanda Morgan LEWIS, Alison Gene-Wei LEE, Nancy Ann LAMON, Terrance Wayne CARONE, II, Ronald Charles BATES, Richard Thomas LUDWIG
Filed: 13 Aug 21
Utility
Substituted Heteroaryl Compounds Useful As Inhibitors of TLR9
12 Oct 23
Chunjian Liu, Alicia Regueiro-Ren
Filed: 18 Aug 21
Utility
Machine Learning Identification, Classification, and Quantification of Tertiary Lymphoid Structures
12 Oct 23
A method includes receiving an input histology image, processing, using a cell classification model, the input histology image to generate one or more lymphocyte density maps within the input histology image, and performing morphological image processing on the one or more lymphocyte density maps to identify one or more TLS regions within the input histology image.
Vanessa Matos-Cruz, George Lee, Varsha Chinnaobireddy, Maryam Pouryahya, Darren Thomas Fahy, Christian Winskell Kirkup, Kathleen Sucipto, Sai Chowdary Gullapally, Archit Khosla, Nishant Agrawal, Benjamin Patrick Glass, Sergine Brutus, Limin Yu, Murray Berle Resnick, Rachel L. Sargent, Vipul Atulkumar Baxi, Scott Ely, Benjamin J. Chen
Filed: 7 Apr 23
Utility
Substituted Oxoisoindoline Compounds for the Treatment of Cancer
12 Oct 23
Andrew P. Degnan, Godwin Kwame Kumi, Andrew J. Tebben, Audris Huang, Peter Kinam Park, Donna M. Bilder, Emily Charlotte Cherney, Ashok Vinayak Purandare
Filed: 22 Mar 21
Utility
Monoclonal Antibodies Against Bcma
12 Oct 23
The invention relates to new antibodies against BCMA, their manufacture and use.
Minh Diem Vu, Klaus Strein, Oliver Ast, Marina Bacac, Camille Delon, Lydia Jasmin Hanisch, Anne Freimoser-Grundschober, Christian Klein, Ekkehard Moessner, Samuel Moser, Pablo Umana, Tina Weinzierl
Filed: 21 Nov 22
Utility
Manufacturing Process for Protein
5 Oct 23
This disclosure provides a novel method of controlling the glycosylation profile of a protein during production.
Amanda Morgan LEWIS, Daniel Robert MASKAS, Eric Richard GARR, Diane Kay WORRELL, Richard Thomas LUDWIG
Filed: 13 Aug 21
Utility
TLR7 Inhibitor In Combination with Prednisolone or Hydroxychloroquine for Treating Cutaneous Lupus Erythematosus
5 Oct 23
Disclosed is method of treating a patient having cutaneous lupus erythematosus, comprising administering to said patient a therapeutically effective dose of a TLR7 inhibitor or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective dose of a second agent selected from prednisolone and hydroxychloroquine or a pharmaceutically acceptable salt thereof.
Gary L. Schieven, Shailesh Dudhgaonkar
Filed: 10 Jun 21
Utility
Treating Rheumatoid Arthritis
5 Oct 23
Disclosed is a method of treating rheumatoid arthritis, comprising administering to a patient a therapeutically effective dose of a TLR7/8 inhibitor or a pharmaceutically acceptable salt thereof, in combination with a therapeutically effective dose of a TNFα inhibitor.
Gary L. Schieven, Shailesh Dudhgaonkar, Michael Louis Doyle
Filed: 21 Jun 21
Utility
1H-PYRROLO[3,2-C]PYRIDINE and 1H-PYRROLO[2,3-C]PYRIDINE Derivatives As TLR9 Inhibitors for the Treatment of Fibrosis
5 Oct 23
Chunjian Liu, Alicia Regueiro-Ren
Filed: 18 Aug 21
Utility
GLYPICAN-3-BINDING Fibronectin Based Scaffold Molecules
5 Oct 23
Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3.
Dasa LIPOVSEK, Joseph TOTH, Ginger C, RAKESTRAW, Irvith M. CARVAJAL, Stanley Richard KRYSTEK, JR., Steven R. O'NEIL, Guodong CHEN, Richard Y. HUANG, Bryan C. BARNHART, John Thomas LOFFREDO, III, Christina TERRAGNI
Filed: 10 Nov 22
Utility
Antagonistic CD40 monoclonal antibodies and uses thereof
3 Oct 23
The disclosure provides for antibodies that bind CD40, including a humanized antibody.
Aaron Yamniuk, Mary Struthers, Stanley R. Krystek, Jr., Akbar Nayeem, Ginger Rakestraw
Filed: 31 Jan 22
Utility
Bromodomain Inhibitor
28 Sep 23
Described herein is the bromodomain inhibitor 4-[2-(cyclopropylmethoxy)-5-methylsulfonylphenyl]-2-methylisoquinolin-1-one, including crystalline forms, amorphous forms, solvates, and hydrates thereof, as well as pharmaceutical compositions that include this bromodomain inhibitor.
Juan Manual Betancort, Jeffrey Alan Stafford, Ryan Stansfield, James Marvin Veal
Filed: 8 May 23
Utility
Cell Localization Signature and Immunotherapy
28 Sep 23
The present disclosure provides methods of identifying a subject suitable for an anti-PD-⅟PD-L1 antagonist therapy comprising measuring assay CD8 localization and PD-L1 expression in a tumor sample obtained from the subject.
George C. LEE, Robin EDWARDS, Scott ELY, Daniel N. COHEN, John B. WOJCIK, Vipul A. BAXI, Dimple PANDYA, Jimena TRILLO-TINOCO, Benjamin J. CHEN, Andrew FISHER, Falon GRAY
Filed: 31 Aug 21
Utility
Oxopyrrolidine Urea FPR2 Agonists
28 Sep 23
Pravin Sudhakar Shirude, Chandrasekhar Reddy Rachamreddy, Vishweshwaraiah Baligar, Balaji Seshadri, Sudhakara Reddy Madduri, Ellen K. Kick, Nicholas R. Wurtz
Filed: 11 Aug 21
Utility
Biomarker Topology Quantification and Assessment for Multiple Tissue Types
28 Sep 23
Described herein are methods and computer systems for classification of CD8 T-cell topology using artificial intelligence and machine learning.
George C. LEE, Robin EDWARDS, Scott ELY, Daniel N. COHEN, John B. WOJCIK, Vipul A. BAXI, Dimple PANDYA, Jimena TRILLO-TINOCO, Benjamin J. CHEN, Andrew FISHER, Falon GRAY
Filed: 31 Aug 21
Utility
Pyridinyl Substituted Oxoisoindoline Compounds
28 Sep 23
Yan Chen, Godwin Kwame Kumi, Audris Huang, Satheesh Kesavan Nair, Bharat Dinkar Shimpukade, Suresh Babu Vishwa Krishna Penmetsa, James Aaron Balog
Filed: 8 Jun 23
Utility
GALECTIN-3 Inhibitors
28 Sep 23
The present disclosure relates to compounds of Formula (I), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods using and making such compounds and compositions.
CHUNJIAN LIU, Wei Wang, Bruce A. Ellsworth, James Aaron Balog, Alicia Regueiro-Ren
Filed: 27 May 21