19 patents
Utility
Antibody Drug Conjugates Comprising Sting Agonists, Combinations and Methods of Use
14 Dec 23
The present disclosure provides combinations comprising HER2-targeted STING agonist antibody-drug conjugates and HER2-targeted therapies or immunotherapies.
Raghida A. BUKHALID, Naniye Cetinbas, Marc I. Damelin, Timothy B. Lowinger, Dorin Toader
Filed: 7 Mar 23
Utility
Compositions and Methods for Predicting Response to NAPI2B-TARGETED Therapy
9 Nov 23
This disclosure provides reagents and methods of predicting the responsiveness of a patient to NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates).
Rebecca MOSHER, Laura L. POLING, Donald A. BERGSTROM
Filed: 26 Jan 23
Utility
NaPi2b-TARGETED POLYMER ANTIBODY-DRUG CONJUGATE FOR THE TREATMENT OF OVARIAN CANCER
26 Oct 23
Disclosed herein are dosing regimens for a NaPi2b-targeted antibody-drug conjugates for treating recurrent, platinum-sensitive ovarian cancer.
Robert A. BURGER
Filed: 9 Sep 22
Utility
Antibody Drug Conjugates Comprising Sting Agonists
12 Oct 23
The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING).
Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
Filed: 19 Dec 22
Utility
Dimeric Compounds As Sting Agonists
9 Mar 23
The present disclosure relates to dimeric STING agonists of Formulae (I), (II), (III), (IV), (V), and (VI), and pharmaceutically acceptable salts thereof.
Jeremy R. DUVALL, Keith W. BENTLEY, Ha Thi DO, Brian D. JONES, Nabeelah I. KAUSER, Eugene W. KELLEHER, Soumya S. RAY, Joshua D. THOMAS, Dorin TOADER, Liping YANG
Filed: 4 Dec 20
Utility
Peptide-containing Linkers for Antibody-drug Conjugates
9 Feb 23
The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
Aleksandr V. YURKOVETSKIY, Natalya D. BODYAK, Bingfan DU, Dmitry R. GUMEROV, Mariya KOZYTSKA, Timothy B. LOWINGER, Cheri A. STEVENSON, Mao YIN
Filed: 12 Aug 21
Utility
Cysteine Engineered Antibody-drug Conjugates with Peptide-containing Linkers
26 Jan 23
The present disclosure relates generally to cysteine engineered antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
Dorin TOADER, Kalli CATCOTT, Timothy B. LOWINGER
Filed: 29 Oct 19
Utility
Antibody Drug Conjugates Comprising Sting Agonists
1 Dec 22
The present disclosure provides scaffolds and antibody-drug conjugates (ADCs) comprising a stimulator of interferon genes (STING).
Jeremy R. DUVALL, Keith W. BENTLEY, Raghida A. BUKHALID, Naniye CETINBAS, Marc I. DAMELIN, Eugene W. KELLEHER, Timothy B. LOWINGER, Joshua D. THOMAS, Dorin TOADER, Ling XU, Liping YANG
Filed: 2 Apr 21
Utility
Combination Therapy of Carboplatin and NAPI2B-TARGETED Polymer Antibody-drug Conjugate for the Treatment of Ovarian Cancer
24 Nov 22
Disclose herein are dosing regimens for a combination of carboplatin and a targeted NaPi2b antibody-drug conjugates for treating cancer.
Robert A. BURGER
Filed: 3 May 22
Utility
NaPi2B-TARGETED POLYMER ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
20 Oct 22
Disclose herein are dosing regimens for targeted NaPi2b antibody-drug conjugates for treating cancer.
Eric P. HAILMAN, Donna M. JARLENSKI, Donald A. BERGSTROM
Filed: 28 Jun 22
Utility
Pyrrolobenzodiazepine Antibody Conjugates
29 Sep 22
The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties.
Joshua D. THOMAS, Brian D. JONES, Eugene W. KELLEHER, Timothy B. LOWINGER, Liping YANG, Mao YIN, Aleksandr V. YURKOVETSKIY
Filed: 21 Dec 18
Utility
Pyrrolobenzodiazepine Antibody Conjugates
22 Sep 22
The present disclosure relates generally to antibody-drug conjugates comprising pyrrolo[2, 1-c][1, 4]benzodiazepine (PBD) drug moieties.
Joshua D. THOMAS, Brian D. JONES, Timothy B. LOWINGER, Shuyi TANG, Mao YIN, Aleksandr V. YURKOVETSKIY
Filed: 27 Nov 18
Utility
B7H4-TARGETED Antibody-drug Conjugates and Methods of Use Thereof
28 Jul 22
The present disclosure relates generally to antibody-drug conjugates comprising monoclonal antibodies that specifically bind the human B7-H4 in soluble form, or membrane bound (i.e., when expressed on a cell surface) and to methods of using these conjugates as therapeutics and/or diagnostics.
Timothy B. LOWINGER, Chen-Ni CHIN, Marc I. DAMELIN, Dorin TOADER
Filed: 4 Jan 22
Utility
Sting Agonist Compounds and Methods of Use
3 Mar 22
The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.
Jeremy R. DUVALL, Keith W. BENTLEY, Brian D. JONES, Eugene W. KELLEHER, Soumya S. RAY, Joshua D. THOMAS, Dorin TOADER
Filed: 9 Sep 21
Utility
NAPI2B-TARGETED Antibody-drug Conjugates and Methods of Use Thereof
30 Sep 21
This disclosure provides NaPi2b-targeted antibody-drug conjugates (e.g., NaPi2b-targeted antibody-polymer-drug conjugates) that specifically bind to the extracellular region of SLC34A2, and to methods of using such conjugates in a variety of therapeutic, diagnostic, and prophylactic indications.
Donald A. BERGSTROM, Natalya D. BODYAK, Timothy B. LOWINGER, Peter U. PARK, Laura L. POLING, Aleksandr V. YURKOVETSKIY
Filed: 20 Jan 21
Utility
Site Specific Antibody-drug Conjugates with Peptide-containing Linkers
22 Jul 21
The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics.
Timothy B. LOWINGER, Marc I. DAMELIN, Dorin TOADER
Filed: 8 Jan 21
Utility
Sting Agonist Compounds and Methods of Use
4 Feb 21
The present disclosure relates to STING (Stimulator of Interferon Genes) agonist compounds, methods of making the compounds and their methods of use.
Jeremy R. DUVALL, Keith W. BENTLEY, Brian D. JONES, Eugene W. KELLEHER, Soumya S. RAY, Joshua D. THOMAS, Dorin TOADER
Filed: 31 Jul 20
Utility
NaPi2B-TARGETED POLYMER ANTIBODY-DRUG CONJUGATES AND METHODS OF USE THEREOF
19 Feb 20
Disclose herein are dosing regimens for targeted NaPi2b antibody-drug conjugates for treating cancer.
Eric P. HAILMAN, Donna M. JARLENSKI, Donald A. BERGSTROM
Filed: 15 Aug 19
Utility
Monoclonal Antibodies Against HER2 Epitope and Methods of Use Thereof
29 Jan 20
This invention provides fully human monoclonal antibodies that recognize HER2.
Natalya D. BODYAK, Michael J. DeVIT, Eric M. KRAULAND, Timothy B. LOWINGER, Peter U. PARK, Bianka PRINZ, Aleksandr V. YURKOVETSKIY
Filed: 1 Oct 19
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