21 patents
Utility
Farnesoid X Receptor Agonists and Uses Thereof
30 Nov 23
Described herein are compounds that are farnesoid X receptor agonists, methods of making such compounds, pharmaceutical compositions and medicaments comprising such compounds, and methods of using such compounds in the treatment of conditions, diseases, or disorders associated with farnesoid X receptor activity.
Nicholas D. SMITH, Steven P. GOVEK, Karensa L. DOUGLAS, Andiliy G. LAI
Filed: 17 Jul 23
Utility
Multilayered Vascular Tubes
12 Oct 23
Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold.
Chirag KHATIWALA, Keith MURPHY, Benjamin SHEPHERD
Filed: 17 Apr 23
Utility
Engineered Three-Dimensional Skin Tissues, Arrays Thereof, and Methods of Making the Same
29 Jun 23
Disclosed are bioprinted, three-dimensional, biological skin tissues comprising: a dermal layer comprising dermal fibroblasts; and an epidermal layer comprising keratinocytes, the epidermal layer in contact with the dermal layer to form the three-dimensional, engineered, biological skin tissue.
Kelsey Nicole RETTING, Colin M. O'NEILL, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Jessica LANGER, Guive BALOOCH, Elizabeth WU, Julien DEMAUDE
Filed: 19 Dec 22
Utility
Use of Engineered Renal Tissues in Assays
21 Jul 22
Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent renal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological renal tubule model.
Shelby Marie KING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL
Filed: 26 Jan 22
Utility
Engineered Intestinal Tissue and Uses Thereof
30 Jun 22
Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Lauran MADDEN
Filed: 15 Mar 22
Utility
Engineered Intestinal Tissue and Uses Thereof
30 Jun 22
Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Lauran MADDEN
Filed: 15 Mar 22
Utility
Methods for Tissue Fabrication
23 Jun 22
Disclosed herein are improved methods for fabricating bioprinted, three-dimensional, biological tissues.
Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Sharon C. PRESNELL, Shelby Marie KING
Filed: 1 Oct 21
Utility
Devices, Systems, and Methods for the Fabrication of Tissue
13 Jan 22
Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge.
Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
Filed: 22 Sep 21
Utility
Devices, Systems, and Methods for the Fabrication of Tissue
13 Jan 22
Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge.
Keith MURPHY, Scott DORFMAN, Nathan SMITH, Larry BAUWENS, Ian SOHN, Tim MCDONALD, Chris LEIGH-LANCASTER, Richard Jin LAW
Filed: 23 Sep 21
Utility
Devices, Systems, and Methods for the Fabrication of Tissue
13 Jan 22
Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge.
Keith MURPHY, Scott DORFMAN, Nathan SMITH, Larry BAUWENS, Ian SOHN, Tim MCDONALD, Chris LEIGH-LANCASTER, Richard Jin LAW
Filed: 24 Sep 21
Utility
Engineered Liver Tissues, Arrays Thereof, and Methods of Making the Same
23 Dec 21
Engineered, living, three-dimensional liver tissue constructs comprising: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct.
Benjamin R. SHEPHERD, Justin B. ROBBINS, Vivian A. GORGEN, Sharon C. PRESNELL
Filed: 2 Sep 21
Utility
Devices, Systems, and Methods for the Fabrication of Tissue
23 Sep 21
Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge.
Keith Murphy, Scott Dorfman, Nathan Smith, Larry Bauwens, Ian Sohn, Tim McDonald, Chris Leigh-Lancaster, Richard Jin Law
Filed: 15 Mar 21
Utility
Engineered Intestinal Tissue and Uses Thereof
16 Sep 21
Disclosed are methods of assessing the ability of a candidate therapeutic agent to reverse, reduce or prevent intestinal injury by a potential toxic agent using a three-dimensional, engineered, bioprinted, biological intestinal tissue model.
Kelsey Nicole RETTING, Deborah Lynn Greene NGUYEN, Lauran MADDEN
Filed: 10 Nov 17
Utility
Engineered Renal Tissues, Arrays Thereof, and Methods of Making the Same
8 Jul 21
Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue.
Deborah Lynn Greene NGUYEN, Shelby Marie KING, Sharon C. PRESNELL
Filed: 25 Mar 21
Utility
Engineered Tissues for in vitro Research Uses, Arrays Thereof, and Methods of Making the Same
29 Apr 21
Disclosed are living, three-dimensional tissue constructs for in vitro scientific and medical research, arrays thereof, and methods of making said tissues and arrays.
Keith MURPHY, Chirag KHATIWALA, Scott DORFMAN, Benjamin SHEPHERD, Sharon PRESNELL, Justin ROBBINS
Filed: 4 Sep 20
Utility
Automated Devices, Systems, and Methods for the Fabrication of Tissue
14 Jan 21
Described herein are improvements to bioprinting technology that facilitate automation of tissue and organ fabrication processes.
Keith MURPHY, Stephen PENTONEY, JR., Frank LIN, Vivian GORGEN, Clay PLATT, Harry Scott RAPOPORT, Samir DAMLE, Vaidehi JOSHI, Sharon C. PRESNELL
Filed: 30 Apr 20
Utility
Platform for Engineered Implantable Tissues and Organs and Methods of Making the Same
24 Jun 20
Disclosed are engineered tissues and organs comprising one or more layers of muscle, the engineered tissue or organ consisting essentially of cellular material, provided that the engineered tissue or organ is implantable in a vertebrate subject and not a vascular tube.
Keith MURPHY, Chirag KHATIWALA, Scott DORFMAN, Benjamin SHEPHERD, Sharon PRESNELL
Filed: 4 Aug 19
Utility
Multilayered Vascular Tubes
17 Jun 20
Described herein are engineered multilayered vascular tubes comprising at least one layer of differentiated adult fibroblasts, at least one layer of differentiated adult smooth muscle cells, wherein any layer further comprises differentiated adult endothelial cells, wherein said tubes have the following features: (a) a ratio of endothelial cells to smooth muscle cells of about 1:99 to about 45:55; (b) the tube is compliant; (c) the internal diameter of the tube is about 6 mm or smaller; (d) the length of the tube is up to about 30 cm; and (e) the thickness of the tube is substantially uniform along a region of the tube; provided that the engineered multilayered vascular tube is free of any pre-formed scaffold.
Chirag KHATIWALA, Keith MURPHY, Benjamin SHEPHERD
Filed: 13 Aug 19
Utility
Engineered Liver Tissues, Arrays Thereof, and Methods of Making the Same
10 Jun 20
Engineered, living, three-dimensional liver tissue constructs comprising: one or more layers, wherein each layer contains one or more liver cell types, the one or more layers cohered to form a living, three-dimensional liver tissue construct.
Benjamin R. SHEPHERD, Justin B. ROBBINS, Vivian A. GORGEN, Sharon C. PRESNELL
Filed: 17 Jul 19
Utility
Engineered Three-Dimensional Breast Tissue, Adipose Tissue, and Tumor Disease Model
15 Apr 20
Described are three-dimensional, engineered, biological breast tissues, adipose tissues, and tumor models, including breast cancer models.
Shelby Marie KING, Deborah Lynn Greene NGUYEN, Vivian A. GORGEN, Benjamin R. SHEPHERD, Sharon C. PRESNELL, Rosalie SEARS, Brittany ALLEN-PETERSEN, Ellen LANGER
Filed: 11 Dec 19