12 patents
Utility
Pregnancy clock proteins for predicting due date and time to birth
21 Dec 23
The present invention provides compositions and methods for due date and time to birth prediction for a pregnancy with significantly higher accuracy than current clinical methods.
John Jay Boniface, Paul Edward Kearney, Julja Burchard, Gregory Charles Critchfield, Durlin Edward Hickok, Tracey Cristine Fleischer, Ashoka Dharmapriya Polpitiya
Filed: 31 Mar 23
Utility
Pregnancy clock proteins for predicting due date and time to birth
30 May 23
Compositions and methods for predicting due date and time to birth for a pregnancy with significantly higher accuracy than current clinical methods.
John Jay Boniface, Paul Edward Kearney, Julja Burchard, Gregory Charles Critchfield, Durlin Edward Hickok, Tracey Cristine Fleischer, Ashoka Dharmapriya Polpitiya
Filed: 17 Aug 18
Utility
Biomarkers and Methods for Predicting Preterm Birth
9 Jun 22
The disclosure provides biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female.
Durlin Edward Hickok, John Jay Boniface, Gregory Charles Critchfield, Tracey Cristine Fleischer
Filed: 21 Jun 21
Utility
Nucleic Acid Biomarkers for Placental Dysfunction
27 Jan 22
The present invention provides compositions and methods for determining a pregnant female's risk of developing placental dysfunction later in the pregnancy.
John Jay Boniface, Julja Burchard, Ryan Michael Treacy, Louise C. Laurent
Filed: 9 Dec 19
Utility
Biomarkers for Predicting Preterm Birth Due to Preterm Premature Rupture of Membranes (Pprom) Versus Idiopathic Spontaneous Labor (PTL)
24 Jun 21
The present invention provides compositions and methods for predicting the probability of preterm birth in a pregnant female.
John Jay Boniface, Julja Burchard, Gregory Charles Critchfield, Tracey Cristine Fleischer, Durlin Edward Hickok, Chien Hsu
Filed: 5 Aug 20
Utility
Biomarker Pairs for Predicting Preterm Birth
17 Jun 21
The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls.
John Jay Boniface, Andrew Gassman, Jeff Flick, Chad Bradford, Ashoka Polpitiya, Tracey Cristine Fleischer, Durlin Edward Hickok, Paul Kearney, Gregory Charles Critchfield
Filed: 1 Mar 21
Utility
Biomarkers and Methods for Predicting Preeclampsia
27 May 21
The disclosure provides biomarker panels, methods and kits for determining the probability for preeclampsia in a pregnant female.
Durlin Edward Hickok, John Jay Boniface, Gregory Charles Critchfield, Tracey Cristine Fleischer
Filed: 2 Jul 20
Utility
Biomarker pairs for predicting preterm birth
30 Mar 21
The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls.
John Jay Boniface, Andrew Gassman, Jeff Flick, Chad Bradford, Ashoka Polpitiya, Tracey Cristine Fleischer, Durlin Edward Hickok, Paul Kearney, Gregory Charles Critchfield
Filed: 10 Apr 19
Utility
Biomarker Pairs for Predicting Preterm Birth
4 Mar 20
The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls.
John Jay Boniface, Andrew Gassman, Jeff Flick, Chad Bradford, Ashoka Polpitiya, Tracey Cristine Fleischer, Durlin Edward Hickok, Paul Kearney, Gregory Charles Critchfield
Filed: 9 Apr 19
Utility
Biomarkers and Methods for Predicting Preterm Birth
11 Dec 19
The disclosure provides biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female.
Durlin Edward Hickok, John Jay Boniface, Gregory Charles Critchfield, Tracey Cristine Fleischer
Filed: 22 Jan 19
Utility
Biomarkers for Predicting Preterm Birth In a Pregnant Female Exposed to Progestogens
4 Dec 19
The present invention provides compositions and methods for predicting the probability of preterm birth in a pregnant female.
John Jay Boniface, Julja Burchard, Gregory Charles Critchfield, Tracey Cristine Fleischer, Durlin Edward Hickok, Todd Lenwell Randolph, Babak Shahbaba
Filed: 20 Dec 18
Utility
Biomarkers and Methods for Predicting Preterm Birth
16 Oct 19
The disclosure provides biomarker panels, methods and kits for determining the probability for preterm birth in a pregnant female.
John Jay Boniface, Gregory Charles Critchfield, Durlin Edward Hickok
Filed: 13 Nov 18
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