485 patents
Page 4 of 25
Utility
Treatment of Major Depressive Disorder
18 May 23
The present disclosure provides methods for the treatment of major depressive disorder by administering cariprazine or a pharmaceutically acceptable salt thereof.
Kumar Budur, Ludmyla Rekeda, Willie R. Earley
Filed: 28 Oct 22
Utility
Medicine container, method of assembling the container, and method of dispensing the medicine from the container
16 May 23
A child-resistant medication container assembly that includes a blister card including a plurality of compartments each configured to support a dosage of medication, and a puck including a body portion, a recess that defines a partition wall in the body portion, and a plurality of openings defined in the partition wall.
Todd Marshall, Bhimaprasad Medhal, John G. Finch, Joy Elizabeth Borgardt
Filed: 13 May 21
Utility
Apoptosis Inducing Agents for the Treatment of Cancer and Immune and Autoimmune Diseases
11 May 23
Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Milan Bruncko, Hong Ding, George A. Doherty, Steven W. Elmore, Lisa A. Hasvold, Laura Hexamer, Aaron R. Kunzer, Xiaohong Song, Andrew J. Souers, Gerard M. Sullivan, Zhi-Fu Tao, Gary T. Wang, Le Wang, Xilu Wang, Michael D. Wendt, Robert Mantei, Todd M. Hansen
Filed: 7 Oct 22
Utility
Modulators of the Integrated Stress Pathway
11 May 23
Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) and for treating related diseases; disorders and conditions.
Kathleen Ann Martin, Carmela Sidrauski, Marina Pliushchev, Yunsong Tong, Xiangdong Xu, Qingwei Zhang, Ramzi Farah Sweis, Michael J. Dart
Filed: 14 Jun 22
Utility
ANTI-CD98 Antibodies and Antibody Drug Conjugates
4 May 23
The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Lorenzo Benatuil, Milan Bruncko, Andrew S. Judd, Yingchun Li, Andrew Mccluskey, Andrew C. Phillips, Darren C. Phillips, Jane Seagal, Andrew J. Souers
Filed: 8 Jun 22
Utility
Injection Device with End of Dose Indicator
4 May 23
An injection device includes a housing having an internal volume and a viewing portion.
Sean Corrigan, Bradley Gould, David T. Andersen, Kelly Burton, Tyler W. Mitchell, Ian Cleathero
Filed: 26 Aug 22
Utility
Anti-alpha-4-beta-7 antibodies
2 May 23
The present disclosure provides anti-α4β7 antibodies that bind human α4β7, their methods of making, and their uses to treat patients with HIV infection.
Jing Min, Teresa (Iok-Chan) Ng, Lorenzo Benatuil, Jacqueline Bixby, Tatyana Dekhtyar, Feng Dong, Axel Hernandez, Jr., Preethi Krishnan, Liangjun Lu, Federico Mensa, Renee Miller, Gautam Sahu
Filed: 16 Jul 21
Utility
Anti-CCR8 antibodies
2 May 23
The present disclosure provides anti-CCR8 antibodies, including compositions and methods of using such antibodies.
Andrew J. McCluskey, Amanda M. Schmidt Paustian, Jane Seagal, Julie L. Wilsbacher
Filed: 27 Jul 22
Utility
Levodopa and Carbidopa Intestinal Gel and Methods of Use
27 Apr 23
The present disclosure provides (a) a pharmaceutical composition comprising a levodopa active agent and a carbidopa active agent and (b) methods of treating Parkinson's disease and associated conditions comprising administering the pharmaceutical composition to a subject with Parkinson's disease.
Alexandru DEAC, Ye HUANG, John M. LIPARI, Alexander RUGGLES, Thin Yu TUN
Filed: 3 Aug 22
Utility
Nicotinamide RIPK1 Inhibitors
27 Apr 23
Kevin Patrick Cusack, Michael Zeller Hoemann, David Andrew Kinsman, Sami Osman, James Patrick Stambuli, Maria Anastasia Argiriadi, Ciaran O'Reilly, Hannah Dexter, Euan Fordyce, Steve St. Gallay
Filed: 8 Aug 22
Utility
Anti-c-Met antibody drug conjugates
25 Apr 23
The present disclosure provides c-Met antibody drug conjugates (ADCs), including compositions and methods of using such ADCs.
Andrew C. Phillips, Regina M. Reilly, George A. Doherty, Cheng Ji, Milan Bruncko, Erwin R. Boghaert, Mark Anderson
Filed: 29 Apr 22
Utility
ANTI-CD98 Antibodies and Antibody Drug Conjugates
20 Apr 23
The invention relates to anti-CD98 antibodies and antibody drug conjugates (ADCs), including compositions and methods of using said antibodies and ADCs.
Lorenzo Benatuil, Milan Bruncko, Andrew S. Judd, Yingchun Li, Andrew Mccluskey, Andrew C. Phillips, Darren C. Phillips, Jane Seagal, Andrew J. Souers
Filed: 27 Apr 22
Utility
Anti-egfr Antibody Drug Conjugates
13 Apr 23
The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.
Erwin R. Boghaert, Milan Bruncko, Andrew S. Judd, Andrew C. Phillips, Andrew J. Souers
Filed: 8 Mar 22
Utility
IL-1 Binding Proteins
13 Apr 23
Proteins that bind IL-1α and IL-1β are described along with their use in compositions and methods for treating, preventing, and diagnosing IL-1-related disorders and for detecting IL-1α and IL-1β in cells, tissues, samples, and compositions.
Chengbin WU, Dominic J. AMBROSI, Chung-ming HSIEH, Tariq GHAYUR
Filed: 29 Apr 22
Utility
Methods of Treating Parkinson's Disease
6 Apr 23
The present disclosure relates to (a) carbidopa prodrugs, (b) pharmaceutical combinations and compositions comprising a carbidopa prodrug and/or an L-dopa prodrug, and (c) methods of treating Parkinson's disease and associated conditions comprising administering a carbidopa prodrug and an L-dopa prodrug to a subject with Parkinson's disease.
Benoit Cardinal-David, Vincent S. Chan, Kassibla E. Dempah, Brian P. Enright, Rodger F. Henry, Raimundo Ho, Ye Huang, Alexander D. Huters, Russell C. Klix, Scott W. Krabbe, Philip R. Kym, Yanbin Lao, Xiaochun Lou, Sean E. Mackey, Mark A. Matulenko, Peter T. Mayer, Christopher P. Miller, James Stambuli, Valentino J. Stella, Eric A. Voight, Zhi Wang, Geoff G. Zhang
Filed: 24 Oct 22
Utility
Bromodomain Inhibitors
30 Mar 23
Andrew Bogdan, Steven Fidanze, Keith McDaniel, John Pratt, Le Wang
Filed: 11 Mar 22
Design
Infusion pump
28 Mar 23
Ian Charles Cleathero, Carsten Petersen
Filed: 29 Jul 19
Utility
Methods of treating Crohn's disease and ulcerative colitis
21 Mar 23
The present disclosure is directed to methods for treating Crohn's disease, and in particular, to methods for inducing clinical remission and/or endoscopic improvement of Crohn's disease, using a JAK1 inhibitor.
Ana Paula Machado De Lacerda, Jose Jeffrey V. Enejosa, Aileen L. Pangan, Mohamed-Eslam F. Mohamed, Ahmed A. Othman, Ben Klünder, Wen Zhou
Filed: 1 Apr 22
Utility
Novel Tricyclic Compounds
16 Mar 23
Neil WISHART, Maria A. ARGIRIADI, David J. CALDERWOOD, Anna M. Ericsson, Bryan A. FIAMENGO, Kristine E. FRANK, Michael M. FRIEDMAN, Dawn M. GEORGE, Eric R. GOEDKEN, Nathan S. JOSEPHSOHN, Biqin C. LI, Michael J. MORYTKO, Kent D. STEWART, Jeffrey W. VOSS, Grier A. WALLACE, Lu WANG, Kevin R. WOLLER
Filed: 14 Jan 22
Utility
Anti-egfr Antibody Drug Conjugates
16 Mar 23
The invention relates to anti-Epidermal Growth Factor Receptor (EGFR) antibody drug conjugates (ADCs) which inhibit Bcl-xL, including compositions and methods of using said ADCs.
Erwin R. Boghaert, Milan Bruncko, Andrew S. Judd, Andrew C. Phillips, Andrew J. Souers
Filed: 10 Sep 21