19 patents
Utility
ANTI-SIGLEC-8 Antibody Formulations
21 Dec 23
The present disclosure provides pharmaceutical compositions (e.g., liquid formulations) comprising a monoclonal antibody that binds to a human Siglec-8 for subcutaneous administration, as well as articles of manufacture related thereto.
Dan YOUEL, Ruby CASARENO
Filed: 21 Oct 21
Utility
Methods and Compositions for Treating Systemic Mastocytosis
19 Oct 23
The invention provides methods and compositions for the prevention and treatment of advanced systemic mastocytosis such as systemic mastocytosis with an associated hematologic non-mast-cell lineage disease (SM-AHNMD).
Christopher Robert BEBBINGTON, Nenad TOMASEVIC, Rustom FALAHATI
Filed: 26 Oct 22
Utility
Anti-Siglec-7 antibodies for the treatment of cancer
3 Oct 23
The invention provides methods and compositions for the treatment of cancer using anti-Siglec7 antibodies.
Christopher Bebbington, Wouter Korver, Nenad Tomasevic, Suzy El Bader, Kenneth Luehrsen
Filed: 4 Aug 17
Utility
Methods and Compositions for Treating Fibrotic Diseases
28 Sep 23
The invention provides methods and compositions for the prevention or treatment of fibrotic diseases such as idiopathic pulmonary fibrosis and pre-fibrotic diseases such as chronic hypersensitivity pneumonitis.
Christopher Robert BEBBINGTON, Nenad TOMASEVIC, Rustom FALAHATI, Bradford Andrew YOUNGBLOOD
Filed: 21 Oct 22
Utility
Methods and Compositions for Treating Irritable Bowel Syndrome and Functional Dyspepsia
1 Dec 22
The present disclosure provides methods for the treatment of irritable bowel syndrome (IBS) and/or functional dyspepsia.
Bhupinder SINGH, Amol KAMBOJ, Henrik RASMUSSEN
Filed: 23 Oct 20
Utility
ANTI-SIGLEC-8 Antibodies and Methods of Use Thereof
20 Oct 22
The invention provides humanized anti-Siglec-8 antibodies and their use in treating and preventing eosinophil-mediated disorders and/or mast cell-mediated disorders, as well as compositions and kits comprising the humanized anti-Siglec-8 antibodies.
Christopher R. BEBBINGTON, Rustom FALAHATI, Carolina Rita SOUSA FERNANDES, David John MATTHEWS, Nenad TOMASEVIC, Jason WILLIAMS, John LEUNG
Filed: 26 Jan 22
Utility
Methods of Administering ANTI-SIGLEC-8 Antibodies and Corticosteroids
18 Aug 22
The present disclosure provides methods and kits suitable for administering a composition comprising an antibody that binds to human Siglec-8, e.g., to a human individual in need thereof.
Bhupinder SINGH, Henrik RASMUSSEN
Filed: 31 Jul 20
Utility
Methods and Compositions for Treating Allergic Ocular Diseases
26 May 22
The present disclosure provides methods for the treatment of an allergic ocular disease (e.g., allergic conjunctivitis, keratoconjunctivitis, or giant papillary conjunctivitis).
Christopher Robert BEBBINGTON, Bradford Andrew YOUNGBLOOD, Nenad TOMASEVIC
Filed: 5 Nov 21
Utility
Methods and Compositions for Treating Mast Cell Gastritis, Mast Cell Esophagitis, Mast Cell Enteritis, Mast Cell Duodenitis, And/or Mast Cell Gastroenteritis
5 May 22
The present disclosure provides methods for the treatment of mast cell gastritis, mast cell esophagitis, mast cell colitis, mast cell enteritis, mast cell duodenitis, and/or mast cell gastroenteritis.
Bradford Andrew YOUNGBLOOD, Bhupinder SINGH, Amol KAMBOJ, Simon GREENWOOD, Henrik RASMUSSEN
Filed: 14 Feb 20
Utility
Methods and compositions for treating perennial allergic conjunctivitis and keratoconjunctivitis
21 Dec 21
The present disclosure provides methods for the treatment of an allergic ocular disease (e.g., allergic conjunctivitis, keratoconjunctivitis, or giant papillary conjunctivitis).
Christopher Robert Bebbington, Bradford Andrew Youngblood, Nenad Tomasevic
Filed: 4 May 18
Utility
Methods and Compositions for Treating Chronic Urticaria
12 Aug 21
The present disclosure provides methods for the treatment of chronic urticaria.
Christopher Robert BEBBINGTON, Nenad TOMASEVIC, Henrik RASMUSSEN
Filed: 3 May 19
Utility
ANTI-SIGLEC-7 Antibodies Having Reduced Effector Function
25 Feb 21
The invention provides methods and compositions for the treatment of cancer using anti-Siglec-7 antibodies that have reduced effector function.
Christopher Bebbington, Wouter Korver, Nenad Tomasevic
Filed: 11 Jan 19
Utility
Methods and compositions for treating fibrotic diseases
14 Sep 20
The invention provides methods and compositions for the prevention or treatment of fibrotic diseases such as idiopathic pulmonary fibrosis and pre-fibrotic diseases such as chronic hypersensitivity pneumonitis.
Christopher Robert Bebbington, Nenad Tomasevic, Rustom Falahati, Bradford Andrew Youngblood
Filed: 15 Jun 16
Utility
Methods and Compositions for Treating Inflammatory Gastrointestinal Disorders
26 Aug 20
The present disclosure provides methods for the treatment of inflammatory bowel disease (IBD) or an eosinophilic gastrointestinal disorder (EGID), such as eosinophilic esophagitis (EOE), eosinophilic gastritis (EG), eosinophilic gastroenteritis (EGE), and eosinophilic colitis (EC).
Christopher Robert BEBBINGTON, Bradford Andrew YOUNGBLOOD, Nenad TOMASEVIC, Emily C. BROCK
Filed: 3 May 18
Utility
Methods and Compositions for Treating Systemic Mastocytosis
10 Jun 20
The invention provides methods and compositions for the prevention and treatment of advanced systemic mastocytosis such as systemic mastocytosis with an associated hematologic non-mast-cell lineage disease (SM-AHNMD).
Christopher Robert BEBBINGTON, Nenad TOMASEVIC, Rustom FALAHATI
Filed: 19 Feb 20
Utility
Methods and Compositions for Treating Allergic Ocular Diseases
13 May 20
The present disclosure provides methods for the treatment of an allergic ocular disease (e.g., allergic conjunctivitis, keratoconjunctivitis, or giant papillary conjunctivitis).
Christopher Robert BEBBINGTON, Bradford Andrew YOUNGBLOOD, Nenad TOMASEVIC
Filed: 3 May 18
Utility
Methods and compositions for treating systemic mastocytosis
30 Mar 20
The invention provides methods and compositions for the prevention and treatment of advanced systemic mastocytosis such as systemic mastocytosis with an associated hematologic non-mast-cell lineage disease (SM-AHNMD).
Christopher Robert Bebbington, Nenad Tomasevic, Rustom Falahati
Filed: 19 Oct 16
Utility
ANTI-SIGLEC-8 Antibodies and Methods of Use Thereof
19 Feb 20
The invention provides humanized anti-Siglec-8 antibodies and their use in treating and preventing eosinophil-mediated disorders and/or mast cell-mediated disorders, as well as compositions and kits comprising the humanized anti-Siglec-8 antibodies.
Christopher R. BEBBINGTON, Rustom FALAHATI, Carolina Rita SOUSA FERNANDES, David John MATTHEWS, Nenad TOMASEVIC, Jason WILLIAMS, John LEUNG
Filed: 16 May 19
Utility
Methods and Compositions for Treating Chronic Obstructive Pulmonary Disorder
6 Nov 19
The present disclosure provides methods for the treatment of chronic obstructive pulmonary disease (COPD) (e.g., non-eosinophilic COPD).
Bradford Andrew YOUNGBLOOD, Nenad TOMASEVIC, Christopher Robert BEBBINGTON
Filed: 4 Jan 18
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