193 patents
Page 2 of 10
Utility
Systems and methods to detect rare mutations and copy number variation
3 Oct 23
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 20 Jan 23
Utility
Microsatellite instability detection in cell-free DNA
3 Oct 23
Provided herein are methods for determining the microsatellite instability status of samples.
Aliaksandr Artsiomenka, Marcin Sikora, Catalin Barbacioru, Darya Chudova, Martina I. Lefterova
Filed: 19 Jun 20
Utility
Methods and systems for detecting genetic variants
26 Sep 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 27 Oct 21
Utility
Methods and systems for detecting genetic variants
26 Sep 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
Amirali Talasaz, Helmy Eltoukhy
Filed: 27 Oct 21
Utility
Population based treatment recommender using cell free DNA
12 Sep 23
Systems and methods are disclosed for generating a therapeutic response predict or detecting a disease, by: using a genetic analyzer to generate genetic information; receiving into computer memory a training dataset comprising, for each of a plurality of individuals having a disease, (1) genetic information from the individual generated at first time point and (2) treatment response of the individual to one or more therapeutic interventions determined at a second, later, time point; and implementing a machine learning algorithm using the dataset to generate at least one computer implemented classification algorithm, wherein the classification algorithm, based on genetic information from a subject, predicts therapeutic response of the subject to a therapeutic intervention.
Helmy Eltoukhy, AmirAli Talasaz
Filed: 7 Oct 16
Utility
Methods and Systems for Detecting Genetic Variants
31 Aug 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli TALASAZ, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER
Filed: 12 May 23
Utility
Methods for Multi-resolution Analysis of Cell-free Nucleic Acids
17 Aug 23
The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample.
Darya CHUDOVA, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER, DIANA ABDUEVA
Filed: 17 Jan 23
Utility
Methods for Multi-resolution Analysis of Cell-free Nucleic Acids
10 Aug 23
The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample.
Darya CHUDOVA, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER, DIANA ABDUEVA
Filed: 14 Nov 22
Utility
Correcting for deamination-induced sequence errors
8 Aug 23
Sequencing nucleic acids can identify variations associated with presence, susceptibility or prognosis of disease.
Marcin Sikora, Andrew Kennedy, Ariel Jaimovich, Darya Chudova, Stephen Fairclough
Filed: 23 Mar 21
Utility
Methods for 3' Overhang Repair
6 Jul 23
Methods of repairing a partially double-stranded DNA fragment are provided.
Eleen SHUM
Filed: 15 Jun 22
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
18 May 23
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ
Filed: 20 Jan 23
Utility
Methods and systems for detecting genetic variants
16 May 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 28 Dec 21
Utility
Methods for Attaching Adapters to Sample Nucleic Acids
11 May 23
Methods of preparing double-stranded nucleic acids with single-stranded overhangs for amplification and sequencing are disclosed.
Andrew KENNEDY, Stefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY, Oliver ZILL, Richard B. LANMAN, Rebecca NAGY, Christine LEE, Kimberley BANKS
Filed: 28 Jun 22
Utility
Compositions and methods for isolating cell-free DNA
9 May 23
Disclosed herein are compositions and methods for isolating DNA, such as cell-free DNA (cfDNA).
Andrew Kennedy, Ariel Jaimovich, Matthew Schultz, William J. Greenleaf
Filed: 31 Jan 20
Utility
Methods for early detection of cancer
9 May 23
Disclosed herein are methods for use in detection of single nucleotide variants (SNVs) or indels.
Stefanie Ann Ward Mortimer, AmirAli Talasaz, Darya Chudova, Helmy Eltoukhy
Filed: 7 Mar 22
Utility
Computer Architecture for Generating a Reference Data Table
4 May 23
An integrated data repository may be generated that includes genomics information and health insurance claims data information for a common group of individuals.
Naveen KUMAR, Jingwen ZHANG, Nisha SUBRAMANIAN, Gautam NAYAK, David HANNA, Shunxin LU
Filed: 30 Sep 22
Utility
Computer Architecture for Identifying Lines of Therapy
4 May 23
A computing machine accesses a pharmacy transaction data set and a medical procedure transaction data set.
Naveen KUMAR, Jingwen ZHANG, Nisha SUBRAMANIAN, Gautam NAYAK, Shunxin LU, Jiemin LIAO, Junhua YU
Filed: 29 Jul 22
Utility
Methods and systems for detecting genetic variants
2 May 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 30 Jun 22
Utility
Methods and systems for detecting genetic variants
2 May 23
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli Talasaz, Helmy Eltoukhy, Stefanie Ann Ward Mortimer
Filed: 28 Jun 22
Utility
Methods and Systems to Improve the Signal to Noise Ratio of Dna Methylation Partitioning Assays
27 Apr 23
In an aspect, the present disclosure provides a method for determining a methylation status comprises: providing a biological sample of nucleic acid molecules; partitioning at least a subset of the nucleic acid molecules in the biological sample based on the methylation status of the nucleic acid molecules into a plurality of partitioned sets; digesting at least a subset of the one or more partitioned sets in the plurality of partitioned sets with at least one methylation sensitive restriction enzyme; enriching at least a subset of the nucleic acid molecules in the plurality of partitioned sets for genomic regions of interest, wherein the at least a subset of the nucleic acid molecules comprises digested nucleic acid molecules in the one or more partitioned sets; and determining methylation status at one or more genetic loci of the nucleic acid molecules in at least one of the partitioned sets.
Andrew KENNEDY, William J. GREENLEAF
Filed: 22 Dec 22