193 patents
Page 5 of 10
Utility
Cancer evolution detection and diagnostic
22 Mar 22
The present disclosure provides methods for determining a probability that after any of a number of therapeutic interventions, an initial state of a subject, such as somatic cell mutational status of a subject with cancer, will develop a subsequent state.
Helmy Eltoukhy, AmirAli Talasaz
Filed: 3 Sep 20
Utility
Computational Detection of Copy Number Variation at a Locus In the Absence of Direct Measurement of the Locus
3 Mar 22
Methods and systems are described for improving detection of copy number loss of a locus of interest without requiring direct measurement of the locus of interest.
Stephen FAIRCLOUGH
Filed: 27 Aug 21
Utility
Methods and Systems for Detecting Genetic Variants
17 Feb 22
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli TALASAZ, Helmy ELTOUKHY
Filed: 27 Oct 21
Utility
Methods and Systems for Detecting Genetic Variants
17 Feb 22
AmirAli TALASAZ, Helmy ELTOUKHY, Stefanie Ann Ward MORTIMER
Filed: 27 Oct 21
Utility
Methods for Detecting Single Nucleotide Variants or Indels by Deep Sequencing
17 Feb 22
Disclosed herein are methods for use in detection of single nucleotide variants (SNVs) or indels.
Stefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY
Filed: 21 Oct 21
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
10 Feb 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz
Filed: 23 Mar 21
Utility
Systems and methods to detect rare mutations and copy number variation
8 Feb 22
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli Talasaz, Stefanie Ann Ward Mortimer
Filed: 13 Oct 20
Utility
Methods to determine tumor gene copy number by analysis of cell-free DNA
8 Feb 22
Methods are provided herein to improve automatic detection of copy number variation in nucleic acid samples.
Helmy Eltoukhy, AmirAli Talasaz, Darya Chudova, Diana Abdueva
Filed: 8 Jan 20
Utility
Homologous Recombination Repair Deficiency Detection
27 Jan 22
Provided herein are methods of generating a homologous recombination repair deficiency (HRD) score, determining a reference HRD score, determining a HRD status of a test subject having one or more cancer types, and/or treating a disease based on HRD status.
Jennifer YEN, Elena HELMAN, Arielle YABLONOVITCH
Filed: 14 May 21
Utility
Methods for Computer Processing Sequence Reads to Detect Molecular Residual Disease
27 Jan 22
Disclosed herein are methods for use in detection of molecular residual disease.
Stefanie Ann Ward MORTIMER, AmirAli TALASAZ, Darya CHUDOVA, Helmy ELTOUKHY
Filed: 2 Jul 21
Utility
Methods and Systems for Determining the Cellular Origin of Cell-free Dna
27 Jan 22
Provided herein are methods for determining the cellular origin of cell-free DNA.
OSCAR WESTESSON, ELENA ZOTENKO
Filed: 19 Aug 21
Utility
Determining Tumor Fraction for a Sample Based on Methyl Binding Domain Calibration Data
30 Dec 21
The application is directed to systems and processes to determine an estimate for tumor fraction of a sample.
Oscar WESTESSON, Yupeng He, William J. GREENLEAF, Ariel JAIMOVICH, AmirAli TALASAZ
Filed: 31 Mar 21
Utility
Correcting for Deamination-induced Sequence Errors
23 Dec 21
Sequencing nucleic acids can identify variations associated with presence, susceptibility or prognosis of disease.
Marcin SIKORA, Andrew KENNEDY, Ariel JAIMOVICH, Darya CHUDOVA, Stephen FAIRCLOUGH
Filed: 23 Mar 21
Utility
Gene Mutations and Copy Number Alterations of Egfr, Kras and Met
23 Dec 21
Sequence variants and copy number variations in the EGFR, KRAS and MET genes are biomarkers for resistance to anti-EGFR therapies for cancer.
Scott KOPETZ, AmirAli TALASAZ
Filed: 22 Jul 21
Utility
Detection and Treatment of Disease Exhibiting Disease Cell Heterogeneity and Systems and Methods for Communicating Test Results
23 Dec 21
This disclosure provides, among other things, methods for generating and applying therapeutic interventions.
Helmy ELTOUKHY, AmirAli TALASAZ, Bahram Ghaffarzadeh KERMANI, Nnamdi IHUEGBU
Filed: 31 Aug 21
Utility
Methods and Systems for Detecting Genetic Variants
23 Dec 21
Disclosed herein in are methods and systems for determining genetic variants (e.g., copy number variation) in a polynucleotide sample.
AmirAli TALASAZ, Helmy ELTOUKHY
Filed: 24 Aug 21
Utility
Significance Modeling of Clonal-level Absence of Target Variants
23 Dec 21
Provided herein are methods of making negative predictions.
Aliaksandr ARTSIOMENKA, Aaron Isaac HARDIN, Stephen FAIRCLOUGH, Marcin SIKORA, Catalin BARBACIORU
Filed: 29 Jan 21
Utility
Normalizing tumor mutation burden
7 Dec 21
Values for tumor mutation burden from different samples can be made more comparable to each other or control standards by a normalization regime that takes into account the minor allele fraction of highly rated mutations in a sample.
Darya Chudova
Filed: 4 May 20
Utility
Methods and Systems for Determining Fusion Events
2 Dec 21
Methods, systems, and apparatuses for determining fusion events are described.
Sante Gnerre
Filed: 12 Feb 21
Utility
Systems and Methods to Detect Rare Mutations and Copy Number Variation
2 Dec 21
The present disclosure provides a system and method for the detection of rare mutations and copy number variations in cell free polynucleotides.
AmirAli TALASAZ, Stefanie Ann Ward MORTIMER
Filed: 6 Aug 21