7 patents
Utility
Methods of Treating Cryptococcus Infections
6 Oct 22
The present disclosure is directed to a method of treating or preventing a fungal infection in a subject including a Cryptococcus spp., which method includes an induction treatment phase and a consolidation treatment phase, wherein the induction treatment phase includes: administering amphotericin B (cAMB) and 5-Flucytosine or an azole to the subject, wherein the cAMB and the 5-Flucytosine or the azole are mucosally administered. cAMB formulations are also disclosed.
Raphael J. MANNINO, Ruying LU, Theresa MATKOVITS
Filed: 13 Aug 20
Utility
Cochleates and methods of using the same to enhance tissue penetration of pharmacologically active agent
19 Jul 22
A cochleate composition is disclosed.
Raphael J. Mannino, Ruying Lu
Filed: 3 Mar 16
Utility
Encholeated Antifungal Compounds for Central Nervous System Delivery and Treatment of Cryptococcus Infections
23 Dec 21
The present application is directed to a cochleate composition including one or more cochleates and at least two anti-fungal compounds selected from amphotericin B, 5-flucytosine, fluconazole, ketoconazole, ravuconazole, albaconazole, itraconazole, oposaconazole, isavuconazole and/or voriconazole.
Raphael J. Mannino, Ruying Lu, Doug F. Kling
Filed: 31 Aug 21
Utility
Encholeated antifungal compounds for central nervous system delivery and treatment of
21 Sep 21
The present application is directed to a cochleate composition including one or more cochleates and at least two antifungal compounds selected from amphotericin B, 5-flucytosine, fluconazole, ketoconazole, ravuconazole, albaconazole, itraconazole, posaconazole, isavuconazole and/or voriconazole.
Raphael J. Mannino, Ruying Lu, Doug F. Kling
Filed: 12 Jul 17
Utility
Cochleates Made with Soy Phosphatidylserine
11 Feb 21
Unpurified or low pure soy phosphatidylserine is used to make cochleates.
Raphael MANNINO, Ruying LU
Filed: 18 Jun 20
Utility
Cochleates made with soy phosphatidylserine
20 Jul 20
Unpurified or low pure soy phosphatidylserine is used to make cochleates.
Raphael Mannino, Ruying Lu
Filed: 12 Nov 17
Utility
Encholeated Antifungal Compounds for Central Nervous System Delivery and Treatment of Cryptococcus Infections
22 Apr 20
The present application is directed to a cochleate composition including one or more cochleates and at least two antifungal compounds selected from amphotericin B, 5-flucytosine, fluconazole, ketoconazole, ravuconazole, albaconazole, itraconazole, posaconazole, isavuconazole and/or voriconazole.
Raphael J. MANNINO, Ruying LU, Doug F. KLING
Filed: 11 Jul 17
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