16 patents
Utility
Treatment of uterine fibroids using purified collagenase
16 Jan 24
Disclosed herein are compositions and methods for treating uterine fibroids in vivo, and methods of reducing symptoms associated with uterine fibroids, including pain, bleeding and infertility.
James H. Segars, Phyllis Carolyn Leppert, Thomas L. Wegman, Jean-Marie Soma
Filed: 14 Oct 20
Utility
Treatment method and product for uterine fibroids using purified collagenase
2 Jan 24
Compositions and methods for treating uterine fibroids are described, wherein a uterine fibroid treatment agent comprising collagenase in an amount effective to cause shrinkage of uterine fibroids is injected or inserted into the uterine fibroid.
Phyllis Carolyn Leppert, Thomas L. Wegman
Filed: 5 Apr 21
Utility
Methods of Reducing Collagenase-mediated Bruising In a Subject Having Cellulite
21 Dec 23
Disclosed herein are methods of reducing collagenase-mediated bruising in a subject having cellulite, methods of treating cellulite in a subject, and collagenase-containing formulations.
Saji Vijayan, David Hernandez, James Patrick Tursi
Filed: 10 May 23
Utility
N-acetylcysteine Compositions and Methods
16 Nov 23
Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics.
Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
Filed: 26 Jul 23
Utility
Method of assessing and treating cellulite
14 Nov 23
The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.
Jeffrey Davidson, Michael McLane, Genzhou Liu
Filed: 30 Aug 21
Utility
Isoproterenol compositions and methods
7 Nov 23
Storage stable aqueous ready-to-administer formulations comprising isoproterenol are presented with desirable stability characteristics.
Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
Filed: 18 Feb 21
Utility
N-acetylcysteine compositions and methods
12 Sep 23
Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics.
Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
Filed: 5 Jul 22
Utility
Hydralazine Compositions and Methods
29 Jun 23
A sterile, ready-to-use pharmaceutical composition having hydralazine and/or a salt thereof at a concentration of less than about 20 mg/mL and a solvent comprising an organic co-solvent, wherein the hydralazine and/or salt thereof and the organic co-solvent are provided at a first weight ratio sufficient for the hydralazine and/or salt thereof to have a change in concentration of no more than about 10% after 2 months of storage at 60° C.
Kumaresh Soppimath, Tushar Hingorani, Hari A. Attluri, Harshil H. Jain
Filed: 27 Dec 22
Utility
Compositions and Methods for Treating Collagen-mediated Diseases
25 May 23
A drug product comprising a combination of highly purified collagenase I and collagenase II from Clostridium histolyticum is disclosed.
Gregory L. Sabatino, Benjamin J. Del Tito, JR., Phillip J. Bassett, Hazel A. Tharia, Antony G. Hitchcock, Bo Yu, Thomas L. Wegman
Filed: 14 Sep 22
Utility
N-acetylcysteine Compositions and Methods
20 Oct 22
Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics.
Ronald DOMALAON, Jinjiang LI, Tushar HINGORANI, Kumaresh SOPPIMATH
Filed: 5 Jul 22
Utility
Method of producing collagenase
18 Oct 22
The present invention relates to the fields of collagenase production and collagenase products, and particularly to improving the reproducibility, purity, and stability of collagenase I and collagenase II compositions, where the compositions are pure to at least 95% by area as measured by reverse phase high pressure liquid chromatography (RP-HPLC) and essentially free of neutral protease.
Christine A. Sheaffer, Michael Berbaum, John Hanna, Jason Dziadosz, Daniel Shanafelt
Filed: 28 Mar 18
Utility
Collagenase Formulations and Methods of Producing the Same
29 Sep 22
Disclosed herein are improved collagenase-containing formulations and methods of preparing the same.
Karunakar SUKURU
Filed: 3 Jan 20
Utility
N-acetylcysteine compositions and methods
16 Aug 22
Storage stable sterile ready-to-administer formulations comprising N-acetylcysteine are presented with desirable stability characteristics.
Ronald Domalaon, Jinjiang Li, Tushar Hingorani, Kumaresh Soppimath
Filed: 17 Feb 21
Utility
Method of Assessing and Treating Cellulite
16 Dec 21
The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.
Jeffrey Davidson, Michael McLane, Genzhou Liu
Filed: 30 Aug 21
Utility
Method of assessing and treating cellulite
21 Sep 21
The present disclosure relates to a method for rating the severity of cellulite on a thigh or buttock in a human subject by utilizing a photonumeric scale that provides reliable results from physician-to-physician and patient-to-patient.
Jeffrey Davidson, Michael McLane, Genzhou Liu
Filed: 1 Mar 18
Utility
Injection Techniques for the Treatment of Cellulite
24 Jun 21
The present disclosure relates to a method of treating cellulite on a thigh or buttock in a human subject by administering an effective amount of collagenase, and then assessing the reduction in the severity of cellulite by one or more scales.
Saji VIJAYAN, Matthew W. DAVIS, Michael MCLANE, George OMBURO, Todd KIRBY
Filed: 12 Jul 19
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