SQZ Biotechnologies (SQZ) USPTO patents

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Methods for Treating Cancer with Activating Antigen Carriers

22 Sep 22

The present application provides activating antigen carriers (AACs) for treating HPV-associated cancers.

Oliver ROSEN

Filed: 28 Dec 21

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Formulations of PBMCS

4 Aug 22

The present application provides formulations of modified peripheral blood mononuclear cells (PBMCs), wherein the formulation comprises: PBMCs comprising at least one antigen (e.g., a human papillomavirus (HPV) antigen) and a cryopreservation medium.

Howard BERNSTEIN, Scott LOUGHHEAD, Matthew BOOTY, Kelan HLAVATY, Tarek ABDELJAWAD, Maisam DADGAR, Jason MURRAY, David CHIRGWIN, Harry AN, Armon R. SHAREI

Filed: 28 Dec 21

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Formulations of Activating Antigen Carriers

28 Jul 22

The present application provides formulations of activating antigen carriers (AACs), wherein the formulation comprises: AACs comprise at least one antigen and an adjuvant and a cryopreservation medium.

Howard BERNSTEIN, Defne YARAR, Katarina BLAGOVIC, Amritha RAMAKRISHNAN, Maisam DADGAR, Louise CLEAR, Jason MURRAY, Tarek ABDELJAWAD, Claire PAGE

Filed: 28 Dec 21

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Methods for Treating Cancers with Modified PBMCS

28 Jul 22

The present application provides modified PBMCs for treating HPV-associated cancers.

Oliver ROSEN, Ruiru JI

Filed: 28 Dec 21

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Microfluidic Chip Having Increased Throughput for Use In a System for Delivery of a Payload into a Cell

30 Jun 22

Provided is a microfluidic chip for causing the delivery of a payload to a cell comprising a first layer, a second layer, and a fluid flow region between the first layer and the second layer.

Maisam DADGAR

Filed: 27 Dec 21

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High-throughput Microfluidic Chip Having Parallelized Constrictions for Perturbing Cell Membranes

30 Jun 22

A microfluidic chip for causing the delivery of a payload to a cell comprises a plurality of constrictions configured to allow a cell suspension to flow through one or more of the plurality of constrictions from a first fluid flow region to a second fluid flow region within the microfluidic chip, wherein a cross-sectional width of each of the plurality of constrictions is less than a diameter of cells in the cell suspension, such that membranes of the cells are perturbed when passing through the constrictions such that a payload is able to pass through the perturbed cell membranes, and wherein a quotient of a cross-sectional area over a cross-sectional perimeter of each of the plurality of constrictions is greater than greater than or equal to 0.5 μm.

Maisam DADGAR, Jacquelyn L. Sikora HANSON, Armon R. SHAREI

Filed: 27 Dec 21

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Intracellular Delivery of Biomolecules to Enhance Antigen Presenting Cell Function

16 Dec 21

The present application provides enhanced antigen presenting cells comprising an agent that enhances the viability and/or function of the antigen presenting cell and/or an antigen and/or an adjuvant, methods of manufacturing such modified antigen presenting cells, and methods of using such modified antigen presenting cells, such as for modulating an immune response in an individual.

Howard BERNSTEIN, Matt BOOTY, Luke CASSEREAU, Jonathan CHOW, Kelan HLAVATY, Scott LOUGHHEAD, Melissa MYINT, Scott SAUER, Armon SHAREI, Vidhya VIJAYAKUMAR

Filed: 3 Oct 19

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Point of Care System for Automatically Processing Cells

25 Nov 21

The present disclosure generally relates to a systems and methods for processing cells, and kits for use with such methods and processes.

Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN

Filed: 21 May 21

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Intracellular Delivery of Biomolecules to Modulate Antibody Production

14 Oct 21

The present invention provides methods and systems for modulating antibody production by passing a cell suspension through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that a compound that modulates antibody production enters the cell.

Armon R. SHAREI, Jonathan B. GILBERT

Filed: 4 Dec 18

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Intracellular Delivery of Biomolecules to Induce Tolerance

13 May 21

The present invention provides methods for inducing tolerance or suppressing an immune response to an antigen by passing a cell suspension containing an immune cell through a constriction, wherein the constriction deforms the cell thereby causing a perturbation of the cell such that an antigen and/or tolerogenic factor enters the cell, thereby generating a tolerogenic and/or immunosuppressive immune cell.

Scott LOUGHHEAD, Jonathan B. GILBERT, Howard BERNSTEIN, Armon R. SHAREI, Finola MOORE

Filed: 3 May 17

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Intracellular Delivery of Biomolecules to Modify Immune Response

22 Apr 21

Provided herein are methods and compositions related to bacteria of genus Burkholderia useful as therapeutic agents.

Scott LOUGHHEAD, LeeAnn TALARICO, Alfonso VICENTE-SUAREZ, Matt BOOTY, Howard BERNSTEIN, Katarina BLAGOVIC, Armon R. SHAREI, Kelan HLAVATY

Filed: 12 Mar 19

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Methods for Treating Hpv-associated Diseases

11 Feb 21

The present application provides immune cells comprising an HPV antigen and an adjuvant, methods of manufacturing such modified immune cells, and methods of using such modified immune cells for treating an HPV-associated disease, preventing an HPV-associated disease and/or for modulating an immune response in an individual with an HPV-associated disease.

Scott LOUGHHEAD, LeeAnn TALARICO, Alfonso VICENTE-SUAREZ, Matt BOOTY, Howard BERNSTEIN, Katarina BLAGOVIC, Armon R. SHAREI, Kelan HLAVATY, Melissa MYINT

Filed: 11 Mar 19

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System for Delivery of a Payload into a Cell

21 Oct 20

A system for delivering a payload to a cell that includes: a platform supporting an input container, an output container, and a receiver for receiving all or part of a disposable assembly, the disposable assembly including a preparation vessel and a constriction cartridge.

Maisam DADGAR, Tarek ABDELJAWAD, Howard BERNSTEIN

Filed: 17 Dec 18

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Cartridge for Use In a System for Delivery of a Payload into a Cell

7 Oct 20

A cartridge for delivering a payload to cells of a cell suspension is provided, wherein the cartridge comprises an input channel that delivers the cell suspension to a first plurality of branch channels, and wherein the first plurality of branch channels each deliver the cell suspension into a respective one or a plurality of microfluidic chips or filters.

Maisam DADGAR

Filed: 5 Apr 20

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DELIVERY OF BIOMOLECULES TO PBMCs TO MODIFY AN IMMUNE RESPONSE

7 Oct 20

The present application provides peripheral blood mononuclear cells comprising an antigen, methods of manufacturing such PBMCs, and methods of using such PBMCs, such as for modulating an immune response in an individual.

Armon R. SHAREI, Howard BERNSTEIN, Scott LOUGHHEAD, Matthew BOOTY, Katarina BLAGOVIC, Kelan HLAVATY, Defne YARAR, Emrah Ilker OZAY, Carolyne Kelly SMITH

Filed: 26 Feb 20

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Intracellular Delivery of Biomolecules Mediated by a Surface with Pores

18 Dec 19

The present disclosure pertains to methods and devices for delivering a compound into a cell, including passing a cell suspension through a surface containing pores, wherein the pores deform the cell thereby causing a perturbation of the cell such that the compound enters the cell, wherein the cell suspension is contacted with the compound.

Jonathan B. GILBERT, Kirubel FREW, Howard BERNSTEIN, Armon R. SHAREI

Filed: 1 Sep 16