33 patents
Utility
Designed Bacterial Compositions for Treating Graft-versus-host-disease
4 Jan 24
Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with immune suppression, including infections and/or GvHD, for example, in HSCT subjects.
Matthew R. HENN, Edward J. O'BRIEN, Ambar PIÑA, Marin VULIC, Christopher B. FORD, Asuncion MARTINEZ, Divya BALASUBRAMANIAN, Elizabeth HALVORSEN, Karen KIESER, Mahmoud SALEH, Mary-Jane LOMBARDO, Sumon DATTA, Madhumitha NANDAKUMAR, Priyanka NARENDAR, Kankana BARDHAN
Filed: 24 Nov 21
Utility
Methods for treatment of Clostridium difficile infection or recurrence or symptoms thereof
22 Aug 23
Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Gregory McKenzie, Mary-Jane Lombardo McKenzie, David N. Cook, Marin Vulic, Geoffrey Von Maltzahn, Brian Goodman, John Grant Aunins, Matthew R. Henn, David Arthur Berry, Jonathan Winkler
Filed: 5 Apr 21
Utility
Synergistic Bacterial Compositions and Methods of Production and Use Thereof
20 Jul 23
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. HENN, Geoffrey von MALTZAHN, Anthony Mario D'ONOFRIO, Kevin Daniel LITCOFSKY, David Arthur BERRY, David N. COOK, Noubar B. AFEYAN, John Grant AUNINS
Filed: 5 Oct 22
Utility
Compositions and methods for treating cholestatic disease
18 Jul 23
The invention provides compositions and methods for use in the treatment and prevention of cholestatic diseases.
Madhumitha Nandakumar, Alice Peiyu Liou, Elizabeth Moritz Halvorsen, Gregory McKenzie, Edward J. O'Brien, David Cook
Filed: 14 Aug 18
Utility
Designed Bacterial Compositions and Uses Thereof
27 Apr 23
Provided herein are bacterial compositions that are useful for treating and preventing complications and side effects associated with a disease or disorder, such as those associated with dysbiosis of a gastrointestinal tract.
Asuncion MARTINEZ, Edward J. O'BRIEN, Sheri Lynn SIMMONS, David COOK, Matthew R. HENN, Christopher B. FORD, Divya BALASUBRAMANIAN, Ambar PIÑA, Liyang DIAO, Meghan CHAFEE, Marin VULIC, Madhumitha NANDAKUMAR, Sumon DATTA, Lata JAYARAMAN
Filed: 25 Nov 20
Utility
Synergistic bacterial compositions and methods of production and use thereof
11 Oct 22
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
Filed: 14 Dec 20
Utility
Synergistic bacterial compositions and methods of production and use thereof
4 Oct 22
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
Filed: 14 Dec 20
Utility
Synergistic bacterial compositions and methods of production and use thereof
4 Oct 22
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. Henn, Geoffrey von Maltzahn, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
Filed: 14 Dec 20
Utility
Synergistic Bacterial Compositions and Methods of Production and Use Thereof
18 Aug 22
Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. HENN, Kevin Daniel LITCOFSKY, Anthony Mario D'ONOFRIO, Toshiro K. OHSUMI, Mary-Jane Lombardo MCKENZIE, Geoffrey VON MALTZAHN, David N. COOK, David Arthur BERRY, Noubar B. AFEYAN, John Grant AUNINS
Filed: 28 Jan 22
Utility
Compositions and Methods for Inhibition of Pathogenic Bacterial Growth
11 Aug 22
Compositions for methods of preventing or reducing pathogenic bacterial growth, proliferation, and/or colonization are described containing one or more types of non-pathogenic bacteria to be introduced into the gastrointestinal tract and effectively compete with pathogenic bacteria for monomeric or polymeric carbohydrate nutrients, and/or amino acid nutrients, and/or vitamin nutrients.
David N. Cook, Han Zhang, Anthony Mario D'Onofrio, David Arthur Berry, Mary-Jane Lombardo McKenzie, John Grant Aunins, Gregory McKenzie, Toshiro K. Ohsumi
Filed: 23 Nov 21
Utility
Synergistic bacterial compositions and methods of production and use thereof
19 Jul 22
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. Henn, Geoffrey von MALTZAHN, Anthony Mario D'Onofrio, Kevin Daniel Litcofsky, David Arthur Berry, David N. Cook, Noubar B. Afeyan, John Grant Aunins
Filed: 14 Dec 20
Utility
Synergistic bacterial compositions and methods of production and use thereof
8 Mar 22
Provided are therapeutic compositions containing microbial populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. Henn, Kevin Daniel Litcofsky, Anthony Mario D'Onofrio, Toshiro K. Ohsumi, Mary-Jane Lombardo McKenzie, Geoffrey von Maltzahn, David N. Cook, David Arthur Berry, Noubar B. Afeyan, John Grant Aunins
Filed: 21 Dec 18
Utility
Compositions for Stabilizing Bacteria and Uses Thereof
20 Jan 22
Provided herein are compositions and formulations that are useful for stabilizing one or more bacteria (e.g., through drying).
Robert K. EVANS, Carl Michael PHILBROOK, Brian Michael SCHUSTER, Lisa MARSHALL
Filed: 5 Dec 19
Utility
Compositions and methods for inhibition of pathogenic bacterial growth
30 Nov 21
Compositions for methods of preventing or reducing pathogenic bacterial growth, proliferation, and/or colonization are described containing one or more types of non-pathogenic bacteria to be introduced into the gastrointestinal tract and effectively compete with pathogenic bacteria for monomeric or polymeric carbohydrate nutrients, and/or amino acid nutrients, and/or vitamin nutrients.
David N. Cook, Han Zhang, Anthony Mario D'Onofrio, David Arthur Berry, Mary-Jane Lombardo McKenzie, John Grant Aunins, Gregory McKenzie, Toshiro K. Ohsumi
Filed: 4 Feb 14
Utility
Treatment of a Cancer by Microbiome Modulation
25 Nov 21
Methods are provided for identifying donors of fecal matter that can improve a subject's response to a checkpoint inhibitor in the treatment of cancer.
Jennifer WORTMAN, Diao LIYANG, Christopher DESJARDINS, Georgios MARNELLOS, Matthew HENN, Jennifer WARGO, Vancheswaran GOPALAKRISHNAN
Filed: 28 Mar 19
Utility
Compositions and Methods
30 Sep 21
Provided are defined bacterial compositions for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for populating the gastrointestinal tract of a subject.
Noubar B. AFEYAN, Mary-Jane LOMBARDO MCKENZIE, Kevin Daniel LITCOFSKY, David N. COOK, Matthew R. HENN, Geoffrey VON MALTZAHN
Filed: 12 Apr 21
Utility
Network-based Microbial Compositions and Methods
19 Aug 21
Provided are therapeutic compositions containing combinations of bacteria, for the maintenance or restoration of a healthy microbiota in the gastrointestinal tract of a mammalian subject, and methods for use thereof.
Matthew R. HENN, David N. COOK, Toshiro K. OHSUMI, Mary-Jane Lombardo MCKENZIE, Kevin D. LITCOFSKY, Han ZHANG, John Grant AUNINS, David Arthur BERRY
Filed: 4 Jan 21
Utility
Compositions and Methods
12 Aug 21
Disclosed herein are therapeutic compositions containing non-pathogenic, germination-competent bacterial spores, for the prevention, control, and treatment of gastrointestinal diseases, disorders and conditions and for general nutritional health.
Gregory MCKENZIE, Mary-Jane LOMBARDO MCKENZIE, David N. COOK, Marin VULIC, Geoffrey VON MALTZAHN, Brian GOODMAN, John Grant AUNINS, Matthew R. HENN, David Arthur BERRY, Jonathan WINKLER
Filed: 5 Apr 21
Utility
Designed Bacterial Compositions and Uses Thereof
1 Jul 21
Our client, Seres Therapeutics, has asked us to file a new provisional application related to bacterial compositions and the use of such compositions for the treatment of inflammatory bowel disease.
Asuncion MARTINEZ, Edward J. O'BRIEN, Sheri Lynn SIMMONS, David COOK, Matthew R. HENN, Christopher B. FORD, Divya BALASUBRAMANIAN, Ambar PIÑA, Liyang DIAO, Meghan CHAFEE, Marin VULIC, Madhumitha NANDAKUMAR, Sumon DATTA, Latta JAYARAMAN
Filed: 24 May 19
Utility
Synergistic Bacterial Compositions and Methods of Production and Use Thereof
10 Jun 21
Provided are therapeutic compositions containing Ecobiotic™ populations for prevention, treatment and reduction of symptoms associated with a dysbiosis of a mammalian subject such as a human.
Matthew R. HENN, Geoffrey von MALTZAHN, Anthony Mario D'ONOFRIO, Kevin Daniel LITCOFSKY, David Arthur BERRY, David N. COOK, Noubar B. AFEYAN, John Grant AUNINS
Filed: 14 Dec 20