37 patents
Utility
Hydrogel Cross-linked Hyaluronic Acid Prodrug Compositions and Methods
28 Dec 23
The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions.
Sebastian STARK, Thomas KNAPPE, Harald RAU, Nicola BISEK, Burkhardt LAUFER, Samuel WEISBROD, Tobias VOIGT
Filed: 27 Mar 23
Utility
Auto Injector with Charger Safety
26 Oct 23
An auto injector is disclosed comprising: a housing, a cartridge receiver, and an ejector member.
Jan Olesen, Flemming Madsen
Filed: 3 Jul 23
Utility
Front Loaded Auto Injector for Administering a Medicament
31 Aug 23
Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament.
Paul Erik Fabricius, Jan Olesen, Steen Jensen, Henrik Egesborg, Per Mølgaard Pedersen
Filed: 21 Feb 23
Utility
Hydrogel Irradiation
3 Aug 23
The present invention relates to a process for the irradiation of a water-insoluble conjugate comprising a polymer Z to which a plurality of moieties -L2-L1-D is covalently conjugated or of a water-insoluble complex comprising a plurality of releasably and non-covalently bound drug molecules D-H or D-OH embedded in a polymer Z′, wherein the process comprises the steps of (a) providing said conjugate or complex; and (b) exposing the conjugate or complex to ionizing radiation; wherein each -L2- is independently a chemical bond or is a spacer moiety; each -L1- is independently a linker moiety covalently and reversibly attached to -D; and each -D is independently a drug moiety.
Oliver Boris STAUCH, Sebastian STARK, Tobias VOIGT, Nicola BISEK
Filed: 3 May 21
Utility
Auto injector with variable plunger force
27 Jun 23
Disclosed is a method and an auto-injector for administering a medicament.
Henrik Egesborg, Steen Jensen, Martin Nørgaard Larsen, Johnny Elkjær, Bjørn Knud Andersen
Filed: 23 May 18
Utility
Hydrogel cross-linked hyaluronic acid prodrug compositions and methods
9 May 23
The present invention relates to hydrogel prodrug compositions comprising cross-linked hyaluronic acid (HA), or a derivative or a salt thereof, wherein the cross-linker system comprises a biodegradable spacer, wherein the cross-linked HA comprises a conjugated drug-linker, and wherein the linker is capable of releasing the drug under physiological conditions.
Sebastian Stark, Thomas Knappe, Harald Rau, Nicola Bisek, Burkhardt Laufer, Samuel Weisbrod, Tobias Voigt
Filed: 19 Sep 19
Utility
Prodrugs comprising an aminoalkyl glycine linker
25 Apr 23
The present invention relates to novel prodrugs of primary or secondary amine- or hydroxyl-comprising biologically active moieties and pharmaceutically acceptable salts thereof, prodrug reagents, pharmaceutical compositions comprising these prodrugs and the use of these prodrugs.
Nicola Bisek, Harald Rau, Felix Cleemann, Thomas Knappe, Romy Reimann
Filed: 4 Aug 15
Utility
Biodegradable Polyethylene Glycol Based Water-Insoluble Hydrogels
20 Apr 23
The present invention relates to biodegradable polyethylene glycol based water-insoluble hydrogels comprising backbone moieties which are interconnected by hydrolytically degradable bonds, the backbone moieties further comprising reactive functional groups, wherein the water-insoluble hydrogel is further characterized in that the ratio between the time period for the complete degradation of the hydrogel by hydrolysis of the degradable bonds into water-soluble degradation products comprising one or more backbone moieties and the time period for the release of the first 10 mol-% of water-soluble degradation products comprising one or more backbone moieties based on the total amount of backbone moieties in the hydrogel is greater than 1 and equal to or less than 2.
Harald Rau, Ulrich Hersel, Mathias Krusch, Dirk Vetter, Tobias Voigt
Filed: 14 Dec 22
Utility
Conjugates Undergoing Intramolecular Rearrangements
13 Apr 23
The present invention relates to conjugates and pharmaceutically acceptable salts thereof, reagents, intermediates, methods for the synthesis of said conjugates, pharmaceutical compositions comprising said conjugates and the use of said conjugates.
Samuel WEISBROD
Filed: 30 Dec 20
Utility
Auto Injector with Reconstitution Handling Support
23 Mar 23
Disclosed herein is an auto injector for administering a medicament, the auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge comprising a first stopper and a cartridge compartment containing the medicament, the cartridge compartment having a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament; a drive module coupled to move a plunger rod between a retracted plunger rod position and an extended plunger rod position, the plunger rod being configured to move the first stopper; a processing unit coupled to the drive module, wherein the processing unit is configured to control the drive module to move the plunger rod from a first plunger rod position to a mix plunger rod position with a mix plunger rod speed, wherein the mix plunger rod position is selected to position the first stopper in a position wherein the first medicament component is mixed with the second medicament component, and to provide an onset signal after a number of completed inversions of the auto injector has been performed.
Steen Jensen, Henrik Egesborg, Bjørn Knud Andersen, Martin Nørgaard Larsen, Johnny Elkjær
Filed: 29 Jun 18
Utility
Front loaded auto injector for administering a medicament
21 Mar 23
Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament.
Paul Erik Fabricius, Jan Olesen, Steen Jensen, Henrik Egesborg, Per Mølgaard Pedersen
Filed: 29 Dec 16
Utility
Auto Injector with Cartridge Locking System
9 Mar 23
An auto injector (4) for administering injection of a medicament from a cartridge containing the medicament, the auto injector (4) comprising: a housing (6); a cartridge receiver (300) with a cartridge receiver compartment (302) configured to receive a cartridge assembly (600), with at least one cartridge retention member (808), when inserted through a cartridge receiver opening (301) along a longitudinal axis (L) in a receiving direction; wherein the cartridge receiver (300) has a passage (316) through which the at least one cartridge retention member (808) travels at least in the receiving direction, and a member (312) preventing movement beyond a retention position in a direction opposite of the receiving direction; an elongated ejector (200) that is configured with: an ejector support face (204) for supporting the cartridge or cartridge assembly (600), a longitudinal ejector slot (228) extending towards the ejector support face (204) from an ejector rest portion (206); wherein the elongated ejector (200) is suspended to move along the longitudinal direction and is spring-loaded in the direction opposite of the receiving direction; and an ejector lock (212) supported for turning at least a fraction of a revolution and maintained in a longitudinal position relative to the housing (6); wherein the ejector lock (212) has a ejector lock support portion (214) that is configured to align with and slide along the longitudinal ejector slot (228) at a first angle and to be brought to align with the ejector rest portion (206) at a second angle.
Thorben Kvisgaard Jacobsen, Jan Olesen
Filed: 11 Nov 22
Utility
Conjugates Of-electron-pair-donating Heteroaromatic Nitrogen-comprising Compounds
2 Mar 23
The present invention relates to conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising drugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said conjugates and the use of said conjugates as medicaments.
Nicola BISEK, Samuel WEISBROD
Filed: 19 Jun 20
Utility
Biodegradable polyethylene glycol based water-insoluble hydrogels
24 Jan 23
The present invention relates to biodegradable polyethylene glycol based water-insoluble hydrogels comprising backbone moieties which are interconnected by hydrolytically degradable bonds, the backbone moieties further comprising reactive functional groups, wherein the water-insoluble hydrogel is further characterized in that the ratio between the time period for the complete degradation of the hydrogel by hydrolysis of the degradable bonds into water-soluble degradation products comprising one or more backbone moieties and the time period for the release of the first 10 mol-% of water-soluble degradation products comprising one or more backbone moieties based on the total amount of backbone moieties in the hydrogel is greater than 1 and equal to or less than 2.
Harald Rau, Ulrich Hersel, Mathias Krusch, Dirk Vetter, Tobias Voigt
Filed: 30 Jul 10
Utility
Auto Injector with Adaptable Air-shot Mechanism
19 Jan 23
Disclosed is an auto injector for administering a medicament.
Per Mølgaard Pedersen, Flemming Madsen, Sven Erik Poulsen, Steen Jensen, Henrik Egesborg
Filed: 29 Jul 22
Utility
Auto injector with cartridge locking system
13 Dec 22
An auto injector for administering injection of a medicament from a cartridge containing the medicament, includes a housing, a cartridge receiver with a cartridge receiver compartment configured to receive a cartridge assembly including at least one cartridge retention member when the cartridge assembly is inserted through a cartridge receiver opening along a longitudinal axis in a receiving direction, an elongated ejector including an ejector support face for supporting the cartridge or the cartridge assembly and a longitudinal ejector slot extending towards the ejector support face from an ejector rest portion, wherein the elongated ejector is suspended to move along the longitudinal direction and is spring-loaded in the direction opposite of the receiving direction, and an ejector lock supported for turning at least a fraction of a revolution and maintained in a longitudinal position relative to the housing.
Thorben Kvisgaard Jacobsen, Jan Olesen
Filed: 29 Dec 16
Utility
Auto injector with adaptable air-shot mechanism
6 Dec 22
Disclosed is an auto injector for administering a medicament.
Per Mølgaard Pedersen, Flemming Madsen, Sven Erik Poulsen, Steen Jensen, Henrik Egesborg
Filed: 29 Dec 16
Utility
Prodrug Comprising a Drug-Linker Conjugate
20 Oct 22
Felix Cleeman, Ulrich Hersel, Silva Kaden, Harald Rau, Thomas Wegge
Filed: 23 Jun 22
Utility
Conjugates of an Electron-donating Nitrogen or Tertiary Amine Comprising Compounds
29 Sep 22
The present invention relates to conjugates of an electron-donating heteroaromatic nitrogen or tertiary amine comprising drugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said conjugates and the use of said conjugates as medicaments.
Nicola BISEK, Samuel WEISBROD
Filed: 19 Jun 20
Utility
Conjugates of Heteroaromatic Nitrogen-comprising Compounds
29 Sep 22
The present invention relates to conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising drugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said conjugates and the use of said conjugates as medicaments.
Nicola BISEK, Samuel WEISBROD
Filed: 19 Jun 20