3 patents
Utility
3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-3-deuteropiperidine-2,6-dione derivatives and compositions comprising and methods of using the same
21 Nov 23
The invention provides 3-deuterium-enriched 3-(5-substituted-4-oxoquinazolin-3(4H)-yl)-piperidine-2,6-diones, deuterated derivatives thereof, stereoisomers thereof, pharmaceutically acceptable salt forms thereof, and methods of treatment using the same, such as in the treatment of cancer, an immune-related disease, or an inflammatory disease.
Sheila DeWitt
Filed: 18 May 21
Utility
Deuterium-enriched isoindolinonyl-azepanediones and related compounds and methods of treating medical disorders using same
3 Oct 23
The invention provides deuterium-enriched isoindolinonyl-azepanediones, deuterium-enriched oxoquinazolin-3(4H)-yl-azepanediones, related compounds, pharmaceutical compositions, and methods of using such compounds and pharmaceutical compositions to treat cancer, angiogenesis disorders, immune disorders, and other medical disorders.
Sheila DeWitt, Vincent Jacques
Filed: 21 Dec 18
Utility
Methods of Inhibiting Lysine-specific Demethylase 1 (LSD-1)
17 Feb 22
Methods of inhibiting LSD1 activity by administering a compound that binds to SWIRM domain of LSD1 and inhibits LSD1 activity; methods of inhibiting LSD1 activity where the compound interacts with L547 residue within the hydrophobic pocket of LSD1; methods of determining the efficacy of a drug to be an LSD1 inhibitor wherein a candidate drug is screened to determine whether it binds to SWIRM domain of LSD1 and inhibits LSD1 activity.
Shawn Blumberg, Jonathan Bohmann, Aundrietta D. Duncan, Stephen Horrigan, Bruce McCreedy, Daniela Santiesteban
Filed: 26 Jul 21
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