45 patents
Page 3 of 3
Utility
Engineered Cascade Components and Cascade Complexes
12 Feb 20
The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides.
Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
Filed: 27 Oct 19
Utility
Modified Cascade Ribonucleoproteins and Uses Thereof
5 Feb 20
A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex comprising at least CRISPR-associated protein subunits Cas7, Cas5 and Cash which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualising, transcription activating or transcription repressing activity.
Stan Johan Jozef Brouns, John van der Oost
Filed: 27 Aug 19
Utility
Engineered nucleic-acid targeting nucleic acids
9 Dec 19
The present disclosure provides engineered cross-type-nucleic-acid targeting nucleic acids and compositions thereof.
Paul Daniel Donohoue, Andrew Paul May
Filed: 17 Dec 18
Utility
Engineered cascade components and cascade complexes
28 Oct 19
The present disclosure provides engineered Class 1 Type I CRISPR-Cas (Cascade) systems that comprise multi-protein effector complexes, nucleoprotein complexes comprising Type I CRISPR-Cas subunit proteins and nucleic acid guides, polynucleotides encoding Type I CRISPR-Cas subunit proteins, and guide polynucleotides.
Peter Sean Cameron, Sanne Eveline Klompe, Samuel Henry Sternberg
Filed: 21 May 19
Utility
Modified cascade ribonucleoproteins and uses thereof
7 Oct 19
A clustered regularly interspaced short palindromic repeat (CRISPR)-associated complex for adaptive antiviral defence (Cascade); the Cascade protein complex comprising at least CRISPR-associated protein subunits Cas7, Cas5 and Cas6 which includes at least one subunit with an additional amino acid sequence possessing nucleic acid or chromatin modifying, visualizing, transcription activating or transcription repressing activity.
Stan Johan Jozef Brouns, John Van Der Oost
Filed: 1 Nov 17