56 patents
Utility
Compositions and methods for phosphoramidite and oligonucleotide synthesis
16 Jan 24
The present disclosure, among other things, provides technologies for oligonucleotide synthesis.
David Charles Donnell Butler, Pachamuthu Kandasamy, Subramanian Marappan, Ik-Hyeon Paik, Jayakanthan Kumarasamy, Gopal Reddy Bommineni
Filed: 22 Nov 17
Utility
Oligonucleotide Compositions and Methods Thereof
7 Dec 23
Among other things, the present disclosure provides oligonucleotides and compositions thereof.
Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Andrew Guzior Hoss, Jigar Desai, Jack David Godfrey, Hailin Yang, Naoki Iwamoto, Jayakanthan Kumarasamy, Anthony Lamattina, Tom Liantang Pu
Filed: 26 Sep 22
Utility
Technologies for Oligonucleotide Preparation
2 Nov 23
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
Keith Andrew Bowman, Chandra Vargeese, David Charles Donnell Butler, Pachamuthu Kandasamy, Mohammed Rowshon Alam, Mamoru Shimizu, Stephany Michelle Standley, Vincent Aduda, Gopal Reddy Bommineni, Snehlata Tripathi, Ilia Korboukh
Filed: 17 Mar 23
Utility
Cells and Non-human Animals Engineered to Express ADAR1 and Uses Thereof
19 Oct 23
Among other things, the present disclosure provides cells and non-human animals engineered to express an ADAR1 polypeptide or a characteristic portion thereof.
Hailin Yang, Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Jack David Godfrey, Naoki Iwanmoto
Filed: 23 Aug 21
Utility
Methods and Compositions of Biologically Active Agents
21 Sep 23
In some embodiments, the present disclosure pertains to compositions and methods related to delivery of a biologically active agent, wherein the compositions comprise a biologically active agent and a lipid.
Chandra Vargeese, Jason Jingxin Zhang, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Naoki Iwamoto, Hailin Yang, Maria David Frank-Kamenetsky, Subramanian Marappan
Filed: 30 Nov 22
Utility
Oligonucleotide Compositions and Methods Thereof
21 Sep 23
Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/ or treating various conditions, disorders or diseases.
Abbie Madeline Maguire, Priyanka Shiva Prakasha, Naoki Iwamoto, Kenneth Allan Longo, Chandra Vargeese, Kevin Kim, Elena Dale, Pachamuthu Kandasamy, Mamoru Shimizu
Filed: 26 Feb 21
Utility
Compounds, compositions and methods for synthesis
8 Aug 23
The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis.
David Charles Donnell Butler, Christopher P. Hencken, Naoki Iwamoto, Pachamuthu Kandasamy, Alvaro Andres Lanao, Genliang Lu, Mamoru Shimizu, Sethumadhavan Divakaramenon, Chandra Vargeese, Gopal Reddy Bommineni, Subramanian Marappan
Filed: 21 Jun 18
Utility
Immunoassays for Detecting Wild Type Huntingtin Protein and Methods of Treatment Employing Such Immunoassays
3 Aug 23
The present disclosure relates to immunoassay methods and immunoassay kits for determining measuring the amount of wild type huntingtin protein in a sample, e.g., a cerebral spinal fluid sample from a Huntington's disease patient, as well as methods of treating Huntington's disease patients employing such immunoassays.
Ramakrishna Bharadwaj Boyanapalli, Jaya Goyal
Filed: 24 Feb 23
Utility
Oligonucleotide Compositions and Methods of Use Thereof
13 Jul 23
Among other things, the present disclosure provides oligonucleotides and compositions thereof.
Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Andrew Guzior Hoss, Jigar Desai, Jack David Godfrey, Hailin Yang, Naoki Iwamoto
Filed: 6 Oct 20
Utility
Double Stranded Oligonucleotide Compositions and Methods Relating Thereto
29 Jun 23
The present disclosure provides double stranded oligonucleotides, compositions, and methods relating thereto.
Chandra VARGEESE, Naoki IWAMOTO, Luciano H. APPONI, David Charles Donnell BUTLER, Pachamuthu KANDASAMY, Subramanian MARAPPAN, Snehlata TRIPATHI, Wei LIU, Mugdha BEDEKAR, Vinod VATHIPADIEKAL
Filed: 24 May 21
Utility
Oligonucleotide Compositions and Methods Thereof
29 Jun 23
The present disclosure provides modified oligonucleotides and compositions and methods thereof.
Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Chandra Vargeese, Subramanian Marappan, Gopal Reddy Bommineni, Mamoru Shimizu, Naoki Iwamoto, Stephany Michelle Standley, Yuanjing Liu, Amy Jada Andreucci, Genliang Lu, Onanong Chivatakarn, Akbar Husain Khan
Filed: 24 May 21
Utility
Oligonucleotide Compositions and Methods of Use Thereof
11 May 23
Among other things, the present disclosure provides RHO oligonucleotides, compositions, and methods.
Michael John Byrne, Vinod Vathipadiekal, Naoki Iwamoto, Chandra Vargeese, Lankai Guo, Andrew Guzior Hoss
Filed: 24 Apr 20
Utility
Chiral control
9 May 23
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.
David Charles Donnell Butler, Naoki Iwamoto, Meena, Nenad Svrzikapa, Gregory L. Verdine, Ivan Zlatev
Filed: 17 Dec 19
Utility
Compositions and Methods for Phosphoramidite and Oligonucleotide Synthesis
4 May 23
The present disclosure, among other things, provides technologies for preparing and purifying phosphoramidites for oligonucleotide synthesis.
David Charles Donnell Butler, Subramanian Marappan, Ik-Hyeon Paik
Filed: 5 Aug 22
Utility
Oligonucleotide compositions and methods thereof
25 Apr 23
Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof.
Maria David Frank-Kamenetsky, Hailin Yang, Aaron Jay Morris, Chandra Vargeese, Christopher J. Francis
Filed: 4 Feb 20
Utility
Technologies Useful for Oligonucleotide Preparation
23 Mar 23
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
Pachamuthu Kandasamy, Mamoru Shimizu, David Charles Donnell Butler, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Mohammed Rowshon Alam, Sethumadhavan Divakaramenon, Bijay Tilak Bhattarai, Chandra Vargeese, Keith Andrew Bowman, Stephany Michelle Standley
Filed: 19 Mar 20
Utility
Technologies for oligonucleotide preparation
21 Mar 23
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
Keith Andrew Bowman, Chandra Vargeese, David Charles Donnell Butler, Pachamuthu Kandasamy, Mohammed Rowshon Alam, Mamoru Shimizu, Stephany Michelle Standley, Vincent Aduda, Gopal Reddy Bommineni, Snehlata Tripathi, Ilia Korboukh
Filed: 17 Sep 18
Utility
Oligonucleotide compositions and methods of use thereof
14 Mar 23
Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods thereof.
Chandra Vargeese, Naoki Iwamoto, David Charles Donnell Butler, Subramanian Marappan, Genliang Lu, Jason Jingxin Zhang, Vinod Vathipadiekal, Maria David Frank-Kamenetsky, Luciano Henrique Apponi, Young Jin Cho
Filed: 1 Jun 18
Utility
Oligonucleotide compositions and methods thereof
7 Mar 23
Among other things, the present disclosure provides technologies for altering splicing, particularly for increasing inclusion of exons in splicing products.
Jason Jingxin Zhang, Chikdu Shakti Shivalila, Chandra Vargeese, Naoki Iwamoto
Filed: 12 Oct 18
Utility
Oligonucleotide compositions and methods of use thereof
7 Mar 23
Among other things, the present disclosure provides designed PNPLA3 oligonucleotides, compositions, and methods thereof.
Chandra Vargeese, Naoki Iwamoto, David Charles Donnell Butler, Subramanian Marappan, Genliang Lu, Jason Jingxin Zhang, Vinod Vathipadiekal, Luciano Henrique Apponi, Hanna Maria Wisniewska, Xiayun Cheng, Young Jin Cho
Filed: 1 Jun 18