37 patents
Utility
Technologies for Oligonucleotide Preparation
2 Nov 23
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
Keith Andrew Bowman, Chandra Vargeese, David Charles Donnell Butler, Pachamuthu Kandasamy, Mohammed Rowshon Alam, Mamoru Shimizu, Stephany Michelle Standley, Vincent Aduda, Gopal Reddy Bommineni, Snehlata Tripathi, Ilia Korboukh
Filed: 17 Mar 23
Utility
Cells and Non-human Animals Engineered to Express ADAR1 and Uses Thereof
19 Oct 23
Among other things, the present disclosure provides cells and non-human animals engineered to express an ADAR1 polypeptide or a characteristic portion thereof.
Hailin Yang, Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Jack David Godfrey, Naoki Iwanmoto
Filed: 23 Aug 21
Utility
Methods and Compositions of Biologically Active Agents
21 Sep 23
In some embodiments, the present disclosure pertains to compositions and methods related to delivery of a biologically active agent, wherein the compositions comprise a biologically active agent and a lipid.
Chandra Vargeese, Jason Jingxin Zhang, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Naoki Iwamoto, Hailin Yang, Maria David Frank-Kamenetsky, Subramanian Marappan
Filed: 30 Nov 22
Utility
Oligonucleotide Compositions and Methods Thereof
21 Sep 23
Among other things, the present disclosure provides oligonucleotides, compositions, and methods for preventing and/ or treating various conditions, disorders or diseases.
Abbie Madeline Maguire, Priyanka Shiva Prakasha, Naoki Iwamoto, Kenneth Allan Longo, Chandra Vargeese, Kevin Kim, Elena Dale, Pachamuthu Kandasamy, Mamoru Shimizu
Filed: 26 Feb 21
Utility
Immunoassays for Detecting Wild Type Huntingtin Protein and Methods of Treatment Employing Such Immunoassays
3 Aug 23
The present disclosure relates to immunoassay methods and immunoassay kits for determining measuring the amount of wild type huntingtin protein in a sample, e.g., a cerebral spinal fluid sample from a Huntington's disease patient, as well as methods of treating Huntington's disease patients employing such immunoassays.
Ramakrishna Bharadwaj Boyanapalli, Jaya Goyal
Filed: 24 Feb 23
Utility
Oligonucleotide Compositions and Methods of Use Thereof
13 Jul 23
Among other things, the present disclosure provides oligonucleotides and compositions thereof.
Prashant Monian, Chikdu Shakti Shivalila, Subramanian Marappan, Chandra Vargeese, Pachamuthu Kandasamy, Genliang Lu, Hui Yu, David Charles Donnell Butler, Luciano Henrique Apponi, Mamoru Shimizu, Stephany Michelle Standley, David John Boulay, Andrew Guzior Hoss, Jigar Desai, Jack David Godfrey, Hailin Yang, Naoki Iwamoto
Filed: 6 Oct 20
Utility
Double Stranded Oligonucleotide Compositions and Methods Relating Thereto
29 Jun 23
The present disclosure provides double stranded oligonucleotides, compositions, and methods relating thereto.
Chandra VARGEESE, Naoki IWAMOTO, Luciano H. APPONI, David Charles Donnell BUTLER, Pachamuthu KANDASAMY, Subramanian MARAPPAN, Snehlata TRIPATHI, Wei LIU, Mugdha BEDEKAR, Vinod VATHIPADIEKAL
Filed: 24 May 21
Utility
Oligonucleotide Compositions and Methods Thereof
29 Jun 23
The present disclosure provides modified oligonucleotides and compositions and methods thereof.
Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Chandra Vargeese, Subramanian Marappan, Gopal Reddy Bommineni, Mamoru Shimizu, Naoki Iwamoto, Stephany Michelle Standley, Yuanjing Liu, Amy Jada Andreucci, Genliang Lu, Onanong Chivatakarn, Akbar Husain Khan
Filed: 24 May 21
Utility
Oligonucleotide Compositions and Methods of Use Thereof
11 May 23
Among other things, the present disclosure provides RHO oligonucleotides, compositions, and methods.
Michael John Byrne, Vinod Vathipadiekal, Naoki Iwamoto, Chandra Vargeese, Lankai Guo, Andrew Guzior Hoss
Filed: 24 Apr 20
Utility
Compositions and Methods for Phosphoramidite and Oligonucleotide Synthesis
4 May 23
The present disclosure, among other things, provides technologies for preparing and purifying phosphoramidites for oligonucleotide synthesis.
David Charles Donnell Butler, Subramanian Marappan, Ik-Hyeon Paik
Filed: 5 Aug 22
Utility
Technologies Useful for Oligonucleotide Preparation
23 Mar 23
Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.
Pachamuthu Kandasamy, Mamoru Shimizu, David Charles Donnell Butler, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Mohammed Rowshon Alam, Sethumadhavan Divakaramenon, Bijay Tilak Bhattarai, Chandra Vargeese, Keith Andrew Bowman, Stephany Michelle Standley
Filed: 19 Mar 20
Utility
Oligonucleotides, Compositions and Methods Thereof
22 Dec 22
The present disclosure pertains to the recognition that immune responses mediated by CpG oligonucleotides can be affected by the stereochemistry of modified internucleotidic linkages such as phosphorothioates.
Jason Jingxin Zhang, Naoki Iwamoto, Christopher J. Francis, Chandra Vargeese, David Charles Donnell Butler, Sethumadhavan Divakaramenon, Genliang Lu, Subramanian Marappan
Filed: 16 Feb 21
Utility
Compounds, Compositions and Methods for Synthesis
10 Nov 22
The present disclosure, among other things, provides technologies for synthesis, including reagents and methods for stereoselective synthesis.
David Charles Donnell Butler, Christopher P. Hencken, Naoki Iwamoto, Pachamuthu Kandasamy, Alvaro Andres Lanao, Genliang Lu, Mamoru Shimizu, Sethumadhavan Divakaramenon, Chandra Vargeese, Gopal Reddy Bommineni, Subramanian Marappan
Filed: 21 Jun 18
Utility
Double-stranded Nucleic Acid Complex and Use Thereof
29 Sep 22
A double-stranded nucleic acid complex is a double-stranded nucleic acid complex including a first nucleic acid strand and a second nucleic acid strand bonded to each other, the second nucleic acid strand including a complementary region having a base sequence complementary to the first nucleic acid strand; the first nucleic acid strand including natural nucleosides and non-natural nucleosides; some of the nucleosides in at least one nucleic acid strand selected from the group consisting of the first nucleic acid strand and the second nucleic acid strand being bonded together by bonds including asymmetric phosphorus atoms; and absolute configurations of the asymmetric phosphorus atoms being regulated.
Takanori YOKOTA, Takeshi WADA, Mamoru SHIMIZU
Filed: 25 Mar 20
Utility
Oligonucleotide Compositions and Methods of Use Thereof
29 Sep 22
Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods of use thereof.
Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian
Filed: 11 Apr 19
Utility
Oligonucleotide Compositions and Methods Thereof
23 Jun 22
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 14 Jul 21
Utility
Oligonucleotide Compositions and Methods Thereof
16 Jun 22
Among other things, the present disclosure provides designed DMD oligonucleotides, compositions, and methods of use thereof.
Jason Jingxin Zhang, Chandra Vargeese, Naoki Iwamoto, Chikdu Shakti Shivalila, Nayantara Kothari, Ann Fiegen Durbin, Selvi Ramasamy, Pachamuthu Kandasamy, Jayakanthan Kumarasamy, Gopal Reddy Bommineni, Subramanian Marappan, Sethumadhavan Divakaramenon, David Charles Donnell Butler, Genliang Lu, Hailin Yang, Mamoru Shimizu, Prashant Monian, Khoa Ngoc Dang Luu
Filed: 6 Dec 19
Utility
Oligonucleotide Compositions and Methods Thereof
26 May 22
Among other things, the present disclosure relates to chirally controlled oligonucleotides of select designs, chirally controlled oligonucleotide compositions, and methods of making and using the same.
Chandra Vargeese, Meena, Nenad Svrzikapa, Susovan Mohapatra, Christopher J. Francis, Gregory L. Verdine, Anna Sokolovska
Filed: 7 May 20
Utility
Oligonucleotide Compositions and Methods of Use Thereof
12 May 22
Among other things, the present disclosure provides C9orf72 oligonucleotides, compositions, and methods thereof.
Yuanjing Liu, Naoki Iwamoto, Chandra Vargeese, Zhong Zhong, Amy Jada Andreucci
Filed: 8 May 20
Utility
Asymmetric Auxiliary Group
28 Apr 22
Mamoru Shimizu, Takeshi Wada
Filed: 2 Sep 21