10 patents
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Compositions Of Engineered Human Arginases And Methods For Treating Cancer
11 Jan 24
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete L-Arginine in serum.
George Georgiou, Everett Stone
Filed: 26 Jan 23
Utility
Method and Composition for Treating Arginase 1 Deficiency
11 Jan 24
A method and composition to treat a subject with arginase 1 (ARG1) deficiency (ARG1-D) and to rapidly reduce the levels of at least one of arginine and/or a guanidino compound in the subject.
Scott W. ROWLINSON, Anthony G. QUINN, Ann LOWE, David LOWE
Filed: 29 Jun 23
Utility
Method and composition for treating arginase 1 deficiency
8 Aug 23
A method and composition to treat a subject with arginase 1 (ARG1) deficiency (ARG1-D) and to rapidly reduce the levels of at least one of arginine and/or a guanidino compound in the subject.
Scott W. Rowlinson, Anthony G. Quinn, Ann Lowe, David Lowe
Filed: 5 Dec 18
Utility
Engineered enzymes with methionine-gamma-lyase enzymes and pharmacological preparations thereof
21 Feb 23
Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described.
George Georgiou, Everett Stone
Filed: 21 Nov 19
Utility
Arginine Depletion Therapy For Treatment of GAMT Deficiency
9 Dec 21
Methods and compositions therefor of treating GAMT deficiency or guanidino acetate (GAA) toxicity in a subject comprising administration of an arginine depleting enzyme.
Anthony G. Quinn, Andreas Schulze, Scott W. Rowlinson
Filed: 18 Oct 19
Utility
Methods For Production Of Human Recombinant Arginase 1 And Uses Thereof
24 Jun 21
Described are methods for producing recombinant Arginase, such as PEGylated, cobalt-substituted recombinant human Arginase 1.
Scott W. Rowlinson
Filed: 28 Aug 20
Utility
Compositions Of Engineered Human Arginases And Methods For Treating Cancer
6 May 21
Compositions and methods for the treatment of cancer are described, and, more preferably, to the treatment of cancers that do not express, or are otherwise deficient in, argininosuccinate synthetase, with enzymes that deplete L-Arginine in serum.
George Georgiou, Everett Stone
Filed: 12 Nov 20
Utility
Compositions and Methods for Treating Cancer with Arginine Depletion and Immuno Oncology Agents
18 Nov 20
Methods of treating tumors or cancer include administration of an arginine depleting enzyme and an immune-oncology agent.
David Lowe, Scott W. Rowlinson, Susan Alters, Giulia Agnello
Filed: 2 Aug 20
Utility
Compositions and methods for treating cancer with arginine depletion and immuno oncology agents
3 Aug 20
Methods of treating tumors or cancer include administration of an arginine depleting enzyme and an immune-oncology agent.
David Lowe, Scott W. Rowlinson, Susan Alters, Giulia Agnello
Filed: 7 Sep 17
Utility
Engineered Enzymes with Methionine-gamma-lyase Enzymes and Pharmacological Preparations Thereof
18 Mar 20
Methods and composition related to the engineering of a novel protein with methionine-γ-lyase enzyme activity are described.
George GEORGIOU, Everett STONE
Filed: 20 Nov 19
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