195 patents
Page 9 of 10
Utility
Optimizing Positions of Electrodes for Applying Tumor Treating Fields (TTFields) by Adding a Dipole to a 3D Model
24 Jun 21
When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by generating a 3D map of electrical conductivity or resistivity of the anatomic volume.
Yoram WASSERMAN, Cornelia WENGER, Pedro Michael Cavaleiro MIRANDA, Zeev BOMZON, Noa URMAN, Eilon KIRSON, Yoram PALTI
Filed: 3 Mar 21
Utility
Cage Assembly for Animal Test Subjects
24 Jun 21
A cage assembly can have at least one enclosure.
SHALOM STRAUSS, YORAM WASSERMAN, SHIRi DAVIDI, RONI BLAT, GOLAN BAR TAL, MOSHE GILADI, MICHAEL KRINITSKY, Michal Munster
Filed: 18 Dec 20
Utility
Swivel Assembly for Actively Limiting Torsion of a Cable, and Systems and Methods of Using Same
24 Jun 21
A swivel assembly can have a longitudinal axis.
MICHAEL KRINITSKY, Yoram Wasserman, Michael Shtotland, Shiri Davidi, Roni Blat, Golan Bar Tal, Moshe Giladi, Shalom Strauss, Michal Munster, Nikolai Piterov
Filed: 18 Dec 20
Utility
Treatment Assembly for Providing Tumor Treating Fields to Animal Test Subjects
24 Jun 21
A treatment assembly can have an inner layer having an inner surface and an outer surface and defining a plurality of openings extending therethrough.
Michal MUNSTER, Yoram WASSERMAN, Michael SHTOTLAND, Shiri DAVIDI, Roni BLAT, Golan Bar TAL, Moshe GILADI, Michael KRINITSKY, Shalom STRAUSS
Filed: 18 Dec 20
Utility
Compositions And Methods For Imaging A Cell
17 Jun 21
Disclosed are methods of imaging a cancer cell, the method comprising applying a first alternating electric field at a first frequency to the cancer cell for a first period of time, wherein application of the first alternating electric field at the first frequency to the cancer cell for the first period of time increases permeability of cell membranes of the cancer cell; introducing a nanoparticle to the cancer cell, wherein the increased permeability of the cell membranes enables the nanoparticle to cross the cancer cell membrane; and imaging the cancer cell.
Tali Voloshin-Sela, Hadas Hershkovish, Ze'ev Bomzon
Filed: 30 Nov 20
Utility
Compositions And Methods Of Altering The Electric Impedance To An Alternating Electric Field
17 Jun 21
Disclosed are compositions for and methods of altering the electric impedance to an alternating electric field in a target site of a subject.
Hadas Hershkovich, Tali Voloshin-Sela, Ze'ev Bomzon
Filed: 30 Nov 20
Utility
Compositions And Methods Of Altering The Electric Impedance To An Alternating Electric Field
17 Jun 21
Disclosed are methods of altering the electric impedance to an alternating electric field in a target site of a subject, comprising introducing a nanoparticle to a target site in the subject; and applying an alternating electric field to the target site of the subject, wherein the electric impedance in the target site of the subject to the alternating current is altered.
Hadas Hershkovich, Tali Voloshin-Sela, Ze'ev Bomzon
Filed: 30 Nov 20
Utility
Methods, Systems, and Apparatuses for Optimizing Transducer Array Placement
3 Jun 21
Methods, systems, and apparatuses are described for optimizing placement of transducer arrays on a patient.
Noa Urman, Reuben Ruby Shamir, Zeev Bomzon, Eduard Fedorov, Yoram Wasserman
Filed: 2 Dec 20
Utility
Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
1 Jun 21
Damage from autoimmune diseases can be prevented or minimized by positioning a plurality of electrodes in or on a subject's body, and applying an AC voltage between the plurality of electrodes so as to impose an alternating electric field through the tissue that is being attacked by the autoimmune disease and/or draining lymph nodes associated with that tissue.
Yaniv Alon, Tali Voloshin-Sela, Moshe Giladi
Filed: 4 Sep 19
Utility
TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
25 May 21
When electrodes are used to impose an electric field in target tissue within an anatomic volume (e.g., to apply TTFields to treat a tumor), the position of the electrodes can be optimized by obtaining electrical conductivity measurements in an anatomic volume and generating a 3D map of the conductivity directly from the obtained electrical conductivity or resistivity measurements, without segmenting the anatomic volume into tissue types.
Cornelia Wenger, Pedro Michael Cavaleiro Miranda, Zeev Bomzon, Noa Urman, Eilon Kirson, Yoram Wasserman, Yoram Palti
Filed: 17 Dec 18
Utility
Perforated Hydrogel Configurations and Methods of Production and Use Thereof
13 May 21
Improved hydrogel configurations for use with a TTField-generating system is disclosed.
Richard Deslauriers
Filed: 6 Nov 20
Utility
Delivering Tumor Treating Fields (TTFields) to the Neck
4 Mar 21
Tumor Treating Fields (TTFields) can be used to treat tumors (and/or prevent metastases) in or near a person's neck by affixing a first transducer array (i.e., a set of electrode elements) to the person's head and affixing a second transducer array to the person's chest.
Yissachar AVRAHAM, Ariel NAVEH, Zeev BOMZON
Filed: 28 Aug 20
Utility
Increasing Cancer Cells' Sensitivity to Tumor Treating Fields (TTFields) by Inhibiting IL11 Activity
11 Feb 21
A reduction in viability of cancer cells (e.g., glioblastoma) and a reduction in tumor volume can be achieved by applying a 100-500 kHz (e.g., 200 kHz) alternating electric field to the cancer cells and inhibiting IL11 (interleukin-11) activity and optionally administering and anti-fibrotic agent.
Tali VOLOSHIN-SELA
Filed: 3 Aug 20
Utility
Applying Tumor Treating Fields (TTFields) Via Electrodes Embedded into Skull Implants
4 Feb 21
Tumors inside a person's head (e.g., brain tumors) can be treated using tumor treating fields (TTFields) by positioning capacitively coupled electrodes on opposite sides of the tumor, and applying an AC voltage between the electrodes.
Yoram WASSERMAN, Uri WEINBERG, Zeev BOMZON
Filed: 24 Jul 20
Utility
Reducing Motility of Cancer Cells Using Tumor Treating Fields (TTFields)
14 Jan 21
The spreading of cancer cells in a target region can be inhibited by imposing a first AC electric field in the target region for a first interval of time, with a frequency and amplitude selected to disrupt mitosis of the cancer cells; and imposing a second AC electric field in the target region for a second interval of time, with a frequency and the amplitude selected to reduce motility of the cancer cells.
Moshe GILADI, Rosa S. SHNAIDERMAN
Filed: 30 Sep 20
Utility
Optimizing Treatment Using TTFields by Changing the Frequency During the Course of Long Term Tumor Treatment
6 Jan 21
Tumors can be treated with an alternating electric field.
Yoram PALTI, Matan DISHON
Filed: 16 Sep 20
Utility
Methods of Treating Glioblastoma
25 Nov 20
The present disclosure provides a method for treating cancer in a patient harboring an EGFR-expressing tumor and/or tumor cell, such as glioblastoma, comprising the combination of (i) applying an AC electric field to a target area, wherein the target area comprises an EGFR-expressing tumor or cancer cell); and (ii) administering an effective amount of depatuxizumab mafodotin.
David MAAG, Moshe GILADI, Rosa S. SCHNAIDERMAN, Einav ZEEVI, Eilon KIRSON
Filed: 18 Nov 18
Utility
Methods, Systems, and Apparatuses for Managing Transducer Array Placement
25 Nov 20
Methods, systems, and apparatuses are described for managing placement of transducer arrays on a subject/patient.
Hadas Sara Hershkovich, Zeev Bomzon, Gil Zigleman, Shira Luk-Zilberman, Ori Kook, Oren Bakalo
Filed: 3 May 20
Utility
Reducing motility of cancer cells using tumor treating fields (TTFields)
2 Nov 20
The spreading of cancer cells in a target region can be inhibited by imposing a first AC electric field in the target region for a first interval of time, with a frequency and amplitude selected to disrupt mitosis of the cancer cells; and imposing a second AC electric field in the target region for a second interval of time, with a frequency and the amplitude selected to reduce motility of the cancer cells.
Moshe Giladi, Rosa S. Shnaiderman
Filed: 2 Apr 17
Utility
Uploading Data from an Isolated System without Compromising Isolation
21 Oct 20
A data transfer apparatus (“DTA”) connects to the field generator in a TTFields therapy system using the same connector on the field generator that is used to connect a transducer interface to the field generator.
Yoram WASSERMAN, Golan BAR-TAL, Michael VARSHAVER, Shimon ELKABETZ
Filed: 12 Apr 20