110 patents
Page 4 of 6
Utility
HTP Engineering Platform
22 Jul 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zachariah SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 22 Mar 21
Utility
Monothioether Crosslinkers In Polymers and Applications Thereof
8 Jul 21
John McNamara, Nicole G. Ricapito, Timothy J. Deming, Eric G. Gharakhanian
Filed: 30 May 19
Utility
Engineered Biosynthetic Pathways for Production of Histamine by Fermentation
17 Jun 21
The present disclosure describes the engineering of microbial cells for fermentative production of histamine and provides novel engineered microbial cells and cultures, as well as related histamine production methods.
Cara Ann Tracewell, Alexander Glennon Shearer, Michael Shareef Siddiqui, Steven M. Edgar, Nicolaus Herman, Murtaza Shabbir Hussain
Filed: 19 Apr 19
Utility
Genotyping Edited Microbial Strains
22 Apr 21
The present invention relates to methods for genotyping microbial host cells that have been subjected to metabolic engineering.
Philip D. WEYMAN, Kedar PATEL, Aaron MILLER, Sara da Luz Areosa CLETO, Kunal MEHTA
Filed: 16 Oct 20
Utility
Automated System for HTP Genomic Engineering
8 Apr 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach SERBER, Erik Jedediah DEAN, Shawn MANCHESTER, Katherine GORA, Michael FLASHMAN, Erin SHELLMAN, Aaron KIMBALL, Shawn SZYJKA, Barbara FREWEN, Thomas TREYNOR, Kenneth S. BRUNO
Filed: 18 Dec 20
Utility
Method for Counterselection In Microorganisms
25 Mar 21
The present disclosure is directed to methods of scarless genomic engineering in microorganisms, such as Bacillus, and provides for new molecular tools and methods which enable scarless genetic editing using at least one counterselectable marker that has been codon optimized for the microorganism.
Tara F. MAHONEY, Amanda Renae REIDER APEL, Paloma RUEDA ROMERO
Filed: 23 Sep 20
Utility
Surface Formulations Comprising Phenols
11 Feb 21
John MCNAMARA, Nicole G. RICAPITO, Alejandra Alvarez ALBARRAN, Joachim C. RITTER, Carol KOCH
Filed: 15 Mar 19
Utility
Microbial Strain Improvement by a HTP Genomic Engineering Platform
28 Jan 21
The present disclosure provides a HTP microbial genomic engineering platform that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Zach SERBER, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Michael Flashman, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Kenneth S. Bruno
Filed: 15 Oct 20
Utility
Insecticidal Protein Discovery Platform and Insecticidal Proteins Discovered Therefrom
21 Jan 21
The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
William W. HWANG, Jeffrey KIM, Oliver LIU, Jennifer SHOCK
Filed: 1 Mar 19
Utility
Insecticidal Protein Discovery Platform and Insecticidal Proteins Discovered Therefrom
23 Dec 20
The disclosure presents a platform for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
William W. HWANG, Jeffrey Kim, Oliver Liu, Jennifer Shock
Filed: 31 Aug 20
Utility
Scalable, Mobile, and Reconfigurable Modules for Processing Biological and Chemical Materials
16 Dec 20
Disclosed are apparatuses, systems, and methods for processing materials, including biological or chemical materials.
Jay S. Davey, Matthew Jonathan Myers, William Serber, Aneesh Khullar, Christopher James Bremner, David J. McLoughlin
Filed: 22 May 19
Utility
Method for Creating a Genomic Library Enriched for Bacillus and Identification of Novel Cry Toxins
9 Dec 20
The disclosure is directed to an approach for discovering novel insecticidal proteins from highly heterogeneous environmental sources.
Jeffrey KIM, Oliver LIU, Jennifer SHOCK, Maritza DUARTE
Filed: 19 Aug 20
Utility
a HTP Genomic Engineering Platform for Improving Escherichia Coli
25 Nov 20
The present disclosure provides a HTP genomic engineering platform for improving Escherichia coli. that is computationally driven and integrates molecular biology, automation, and advanced machine learning protocols.
Matthew Davis, Christy Wisnewski, Patrick Westfall, Zach Serber, Erik Jedediah Dean, Shawn Manchester, Katherine Gora, Erin Shellman, Aaron Kimball, Shawn Szyjka, Barbara Frewen, Thomas Treynor, Michael Flashman, Robert Haushalter, Stacy-Anne Morgan, Michael Blaisse, Prabha Ramakrishnan, Kyle Rothschild-Mancinelli, Youngnyun Kim
Filed: 5 Jun 18
Utility
Nepetalactol Oxidoreductases, Nepetalactol Synthases, and Microbes Capable of Producing Nepetalactone
18 Nov 20
The present disclosure provides isolated nepetalactone oxidoreductase polypeptides (NORs), nepetalactol synthases (NEPSs), and related polynucleotides, engineered host cells, and cultures, as well as methods for producing NORs and NEPSs, and for using them to produce nepetalactol, nepetalactone, and dihydronepetalactone.
Grayson Wawrzyn, Christine Roche, Patrick J. Westfall, Warren Lau, Savita Ganesan, Fern R. McSorley, Zach Serber
Filed: 28 May 20
Utility
Genome Editing Using Crispr In Corynebacterium
18 Nov 20
A CRISPR system is successfully used to modify the genomes of a gram-positive bacterium, such as a species of the Corynebacterium genus.
Stephen BLASKOWSKI, Robert COATES, Kedar PATEL, Hendrik Marinus VAN ROSSUM, Shawn SZYJKA
Filed: 29 Jul 20
Utility
Optimization of Organisms for Performance In Larger Scale Conditions Based on Performance In Smaller Scale Conditions
11 Nov 20
Systems, methods and computer-readable media storing executable instructions are provided for improving performance of an organism with respect to a phenotype of interest at a second scale based upon measurements at a first scale.
Stefan De Kok, Peter Enyeart, Richard Hansen, Trent Hauck, Zachariah Serber, Amelia Taylor, Thomas Treynor, Kristina Tyner, Sarah Lieder
Filed: 8 Nov 18
Utility
HTP Platform for the Genetic Engineering of Chinese Hamster Ovary Cells
4 Nov 20
Presented herein is a high-throughput (HTP) genomic engineering platform for improving the production of therapeutic proteins in Chinese hamster ovary (CHO) cells.
Kate CAVES, Amar Singh
Filed: 19 Jul 20
Utility
Device-agnostic System for Planning and Executing High-throughput Genomic Manufacturing Operations
4 Nov 20
High-throughput production of modified microbes is achieved through optimization of directed build graph data structures representing biological workflows.
Kiyan Ahmadizadeh, Tessa Alexanian, Barbara Frewen, Prasad Ganesan, Aaron Kimball, William J. Mania, Zachary Palchick, Erin Rhode, Dylan Webster
Filed: 24 Oct 18
Utility
Apparatuses and Methods for Electroporation
14 Oct 20
Disclosed are apparatuses, systems, and methods for performing electroporation.
John Cesarek, Travis Lee, Richard Hansen
Filed: 25 Jun 20
Utility
Identifying Organisms for Production Using Unsupervised Parameter Learning for Outlier Detection
30 Sep 20
Systems, methods and computer-readable media are provided for identifying organisms for production.
Amelia Taylor
Filed: 29 Nov 18