9 patents
Utility
Analysis and prediction of traumatic brain injury and concussion symptoms
27 Sep 22
Provided are methods for detecting or diagnosing a traumatic brain injury or TBI by detecting concentration levels miRNAs associated with TBI in saliva.
Steven D. Hicks, Frank A. Middleton, Richard Uhlig
Filed: 23 Mar 18
Utility
Molecular and Functional Characterization of Early-stage Parkinson's Disease and Treatments Therein
10 Feb 22
A method and composition for detecting, diagnosing, prognosing or monitoring a subject suspected of having or having Parkinson's disease by detecting miRNAs and microbial RNAs in saliva.
Frank A. MIDDLETON, Richard UHLIG
Filed: 18 Oct 19
Utility
Analysis of autism spectrum disorder
8 Feb 22
This application provides methods to differentiate between subjects with autism spectrum disorder (ASD) and typically developing (TD) or developmentally delayed (DD) subjects using miRNA and/or microbiome levels detected in saliva samples and patient information.
Steven D. Hicks, Frank A. Middleton, Richard Uhlig, Alexander Rajan
Filed: 22 Mar 18
Utility
Methods and Machine Learning for Disease Diagnosis
9 Dec 21
A machine learning classifier that diagnoses autism spectrum disorder (ASD) is described that transforms data obtained from a patient medical history and a patients saliva into data that correspond to a test panel of features, the data for the features including human microtranscriptome and microbial transcriptome data, wherein the transcriptome data are associated with respective RNA categories for ASD.
Alexander RAJAN, Steven D. HICKS, Frank A. MIDDLETON
Filed: 25 Oct 19
Utility
Salivary Microrna Levels In Anorexia Nervosa Provide a Liquid Biopsy of Metabolic and Neuropsychiatric Status
6 May 21
A method for detecting a risk of, diagnosing, prognosing, or monitoring anorexia nervosa or another eating disorder or for distinguishing a healthy subject from one with anorexia, an eating disorder, or an anxiety disorder comprising detecting at least one abnormal or altered pattern of miRNA and/or microbial RNA in biological sample compared to a control value from one or more normal subjects or healthy controls, and selecting a subject having at least one abnormal or altered pattern of miRNA and/or microbial RNA correlated with anorexia nervosa or another eating disorder.
Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG
Filed: 15 Apr 19
Utility
a Method for Monitoring Metabolism Before and after Exercise or Injury Using Salivary Micro-rnas
30 Dec 20
A method for evaluating or monitoring metabolic effects of exercise or injury by detecting and/or quantifying microR-NAs in saliva.
Richard UHLIG, Steven D. HICKS, Frank A. MIDDLETION
Filed: 26 Feb 19
Utility
Analysis and Prediction of Traumatic Brain Injury and Concusion Symptoms
2 Sep 20
Provided are methods for detecting or diagnosing a traumatic brain injury or TBI by detecting concentration levels miRNAs associated with TBI in saliva.
Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG
Filed: 22 Mar 18
Utility
Analysis of Autism Spectrum Disorder
20 May 20
This application provides methods to differentiate between subjects with autism spectrum disorder (ASD) and typically developing (TD) or developmentally delayed (DD) subjects using miRNA and/or microbiome levels detected in saliva samples and patient information.
Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG, Alexander RAJAN
Filed: 21 Mar 18
Utility
Method for Diagnosing or Monitoring Conditions Characterized by Abnormal Temporal Variations and Method of Normalizing Epigenetic Data to Compensate for Temporal Variations
20 May 20
Methods for diagnosing or monitoring a condition, disorder or disease associated with circadian, diurnal or other temporal rhythms by detecting circa-miRNAs and circa-microbiomes associated with said condition, disorder or disease.
Steven D. HICKS, Frank A. MIDDLETON, Richard UHLIG
Filed: 19 Mar 18
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