2 patents
Utility
Synthetic RIG-I-like receptor agonists
2 Feb 21
The present disclosure relates to, inter alia, RNA molecules (e.g., RNA hairpin agonists) that bind to and agonize RIG-I-like receptors (RLRs), and to use of the molecules in methods for treating, or ameliorating one or more symptoms of, a disorder (e.g., cancer).
Arthur M. Krieg, Aaron Jay Morris
Filed: 19 Apr 19
Utility
Combination tumor immunotherapy
15 Jun 20
Provided are methods for treating cancer using local administration of certain CpG oligonucleotides (CpG ODN) and systemic administration of a checkpoint inhibitor such as an anti-PD-1 antibody, an anti-PD-L1 antibody, and/or an anti-CTLA-4 antibody.
Arthur M. Krieg
Filed: 21 Dec 15
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