21 patents
Utility
Compounds for the treatment, alleviation or prevention of disorders associated with Tau aggregates
14 Nov 23
The present invention relates to novel compounds that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).
Sreenivasachary Nampally, Emanuele Gabellieri, Jerome Molette
Filed: 9 Jan 20
Utility
Method of safe administration of phosphorylated tau peptide vaccine
27 Jun 23
Methods for inducing anti-phosphorylated Tau antibodies without inducing a severe adverse event in humans are described.
Andrea Pfeifer, Andreas Muhs, Maria Pihlgren Bosch, Marija Vukicevic Verhille, Nicolas Piot, Saroj Raj Ghimire, Elizabeth Anne Ramsburg, Donata De Marco, Charlotte Sadaka
Filed: 7 Feb 20
Utility
Compounds for the treatment, alleviation or prevention of disorders associated with tau aggregates
27 Jun 23
Sreenivasachary Nampally, Emanuele Gabellieri, Jerome Molette
Filed: 30 May 19
Utility
Bicyclic compounds for diagnosis and therapy
11 Apr 23
The present invention relates to novel compounds that can be employed in the diagnosis, monitoring of disease progression or monitoring of drug activity, of a group of disorders and abnormalities associated with alpha-synuclein (α-synuclein, A-synuclein, aSynuclein, A-syn, α-syn, aSyn) aggregates including, but not limited to, Lewy bodies and/or Lewy neurites, such as Parkinson's disease.
Jérôme Molette, Emanuele Gabellieri, Vincent Darmency
Filed: 5 Jun 20
Utility
Heterologous administration of tau vaccines
28 Feb 23
Methods for inducing an immune response against tau protein in a subject suffering from a neurodegenerative disease, disorder or condition, such as Alzheimer's Disease, are described.
Elizabeth Anne Ramsburg, Donata De Marco, Chakkumkal Anish, Charlotte Sadaka, Jaap Goudsmit, Andreas Muhs, Maria Pihlgren Bosch, Marija Vukicevic Verhille, David Hickman, Nicolas Piot, Saroj Raj Ghimire
Filed: 23 Apr 20
Utility
Anti-Tau antibodies and methods of use
17 Jan 23
The invention provides anti-Tau antibodies and methods of using the same.
Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
Filed: 3 Dec 20
Utility
Mimotopes of alpha-synuclein and vaccines thereof for the treatment of synucleinopathy
27 Dec 22
A method of treating a synucleinopathy with a peptide (C)DQPVLPD (SEQ ID NO: 59), (C)DMPVLPD (SEQ ID NO: 60), (C)DSPVLPD (SEQ ID NO: 61), (C)DQPVLPDN (SEQ ID NO: 64), (C)DMPVLPDN (SEQ ID NO: 65), (C)DSPVLPDN (SEQ ID NO: 66), (C)HDRPVTPD (SEQ ID NO: 70), (C)DRPVTPD (SEQ ID NO: 71), (C)DVPVLPD (SEQ ID NO: 72), (C)DTPVYPD (SEQ ID NO: 73), (C)DTPVIPD (SEQ ID NO: 74), (C)HDRPVTPDN (SEQ ID NO: 75), (C)DRPVTPDN (SEQ ID NO: 76), (C)DVPVLPDN (SEQ ID NO: 78), (C)DTPVYPDN (SEQ ID NO: 79), (C)DQPVLPDG (SEQ ID NO: 81), (C)DMPVLPDG (SEQ ID NO: 82), (C)DSPVLPDG (SEQ ID NO: 83), (C)DHPVHPDS (SEQ ID NO: 86), (C)DMPVSPDR (SEQ ID NO: 87), (C)DRPVYPDI (SEQ ID NO: 90), (C)DHPVTPDR (SEQ ID NO: 91), (C)DTPVLPDS (SEQ ID NO: 93), (C)DMPVTPDT (SEQ ID NO: 94), (C)DAPVTPDT (SEQ ID NO: 95), (C)DSPVVPDN (SEQ ID NO: 96), (C)DLPVTPDR (SEQ ID NO: 97), (C)DSPVHPDT (SEQ ID NO: 98), (C)DAPVRPDS (SEQ ID NO: 99), (C)DMPVWPDG (SEQ ID NO: 100), (C)DRPVQPDR (SEQ ID NO: 102), (C)YDRPVQPDR (SEQ ID NO: 103), (C)DMPVDADN (SEQ ID NO: 105), DQPVLPD(C) (SEQ ID NO: 106), and DMPVLPD(C) (SEQ ID NO: 107.
Markus Mandler, Harald Weninger, Radmila Santic, Edith Kopinits
Filed: 11 Dec 19
Utility
Misfolded TDP-43 binding molecules
11 Oct 22
The present invention is in the field of transactive response DNA binding protein with a molecular weight of 43 kDa (TARDB or also TDP-43).
Tamara Seredenina, Oskar Adolfsson
Filed: 4 Jan 19
Utility
Anti-Tau antibodies and methods of use
30 Aug 22
The invention provides anti-Tau antibodies and methods of using the same.
Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
Filed: 5 Jun 20
Utility
Anti-tau antibodies and methods of use
7 Jun 22
The invention provides anti-Tau antibodies and methods of using the same.
Oskar Adolfsson, Kristin Ruth Wildsmith, Marcel Van Der Brug, Andreas Muhs
Filed: 9 Oct 20
Utility
Gamma-carboline compounds for the detection of Tau aggregates
19 Apr 22
Mathias Berndt, Andre Müller, Felix Oden, Hanno Schieferstein, Heribert Schmitt-Willich, Heiko Kroth, Jérôme Molette
Filed: 22 Jan 19
Utility
Compositions of phosphorylated tau peptides and uses thereof
21 Sep 21
Liposomes containing tau peptides, preferably phosphorylated tau peptides, and conjugates containing tau peptides, preferably phosphorylated tau peptides, conjugated to an immunogenic carrier are described.
Elizabeth Anne Ramsburg, Donata De Marco, Charlotte Sadaka, Jaap Goudsmit, Andreas Muhs, Maria Pihlgren Bosch, Marija Vukicevic Verhille, Nicolas Piot, Saroj Raj Ghimire
Filed: 24 Oct 18
Utility
Compounds for imaging Tau protein aggregates
14 Dec 20
Heiko Kroth, Jérôme Molette, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden
Filed: 20 Jul 17
Utility
Compounds for imaging Tau protein aggregates
16 Nov 20
Heiko Kroth, Jérôme Molette, Vincent Darmency, Hanno Schieferstein, Andre Müller, Heribert Schmitt-Willich, Mathias Berndt, Felix Oden, Emanuele Gabellieri
Filed: 20 Jul 17
Utility
Anti-Tau antibodies and methods of use
16 Nov 20
The invention provides anti-Tau antibodies and methods of using the same.
Oskar Adolfsson, Kristin Ruth Wildsmith, Marcel Van Der Brug, Andreas Muhs
Filed: 22 May 19
Utility
Anti-abeta therapeutic vaccines
9 Nov 20
A liposomal vaccine composition comprises a β-amyloid (Aβ)-derived peptide antigen displayed on the surface of the liposome.
Emma Fiorini, Marija Vukicevic Verhille, Maria Pihlgren Bosch
Filed: 8 Apr 19
Utility
Anti-Tau antibodies and methods of use
13 Jul 20
The invention provides anti-Tau antibodies and methods of using the same.
Oskar Adolfsson, Isidro Hotzel, Danielle DiCara
Filed: 22 May 19
Utility
Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins
25 May 20
The present invention relates to novel compounds that can be employed in the diagnosis, treatment, alleviation or prevention of a group of disorders and abnormalities associated with amyloid proteins and amyloid-like proteins, such as Alzheimer's disease.
Heiko Kroth, Sreenivasachary Nampally, Jér{hacek over (o)}me Molette, Emanuele Gabellieri, Pascal André René Benderitter, Wolfgang Froestl, Hanno Schieferstein, Andre Mueller, Heribert Schmitt-Willich, Mathias Berndt
Filed: 20 Jan 15
Utility
Compounds for the treatment, alleviation or prevention of disorders associated with Tau aggregates
27 Apr 20
The present invention relates to novel compounds that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).
Sreenivasachary Nampally
Filed: 12 Mar 19
Utility
Anti-tau antibodies and methods of use
27 Apr 20
The invention provides anti-Tau antibodies and methods of using the same.
Oskar Adolfsson, Gai Ayalon, Isidro Hotzel, Danielle Marie Di Cara
Filed: 6 May 19