15 patents
Utility
Methods and Compositions for Treating Amyotrophic Lateral Sclerosis
23 Nov 23
Provided herein are methods and compositions for treating a neurodegenerative disease (e.g., ALS).
Joshua Cohen, Justin Klee
Filed: 17 May 22
Utility
Methods and Compositions for Treating Amyotrophic Lateral Sclerosis
16 Nov 23
Provided herein are methods for treating at least one symptom of ALS in a subject who has received a first dosage of BSEP inhibitor, the method including administering to the subject a composition comprising a bile acid or a pharmaceutically acceptable salt thereof and a phenylbutyrate compound, monitoring the subject for response to the BSEP inhibitor, and administering a second dosage of the BSEP inhibitor, wherein the second dosage is less than the first dosage.
Joshua Cohen, Justin Klee
Filed: 12 May 22
Utility
Methods and Compositions for Treating Amyotrophic Lateral Sclerosis
7 Sep 23
Provided herein are methods for treating at least one symptom of ALS in a subject who has received a first dosage of a substrate of a CYP or a transporter, the method including administering to the subject a composition comprising a bile acid or a pharmaceutically acceptable salt thereof and a phenylbutyrate compound, monitoring the subject for response to the substrate, and administering a second dosage of the substrate, wherein the second dosage is less than the first dosage.
Joshua Cohen, Justin Klee
Filed: 2 Mar 22
Utility
Compositions of Bile Acids and Phenylbutyrate Compounds
6 Jul 23
The present disclosure relates to compositions including a phenylbutyrate compound and a bile acid, and methods of processing such compositions.
Joshua Cohen, Justin Klee, David Wai Fung Ma
Filed: 8 Dec 22
Utility
Compositions of bile acids and phenylbutyrate compounds
21 Feb 23
The present disclosure relates to compositions including a phenylbutyrate compound and a bile acid, and methods of processing such compositions.
Joshua Cohen, Justin Klee, David Wai Fung Ma
Filed: 27 Jul 20
Utility
Compositions of bile acids and phenylbutyrate compounds
24 Jan 23
The present disclosure relates to compositions including a phenylbutyrate compound and a bile acid, and methods of processing such compositions.
Joshua Cohen, Justin Klee, David Wai Fung Ma
Filed: 21 Dec 21
Utility
Compositions for Improving Cell Viability and Methods of Use Thereof
26 May 22
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell.
Joshua Cohen, Justin Klee
Filed: 2 Nov 21
Utility
Compositions of Bile Acids and Phenylbutyrate Compounds
21 Apr 22
The present disclosure relates to compositions including a phenylbutyrate compound and a bile acid, and methods of processing such compositions.
Joshua Cohen, Justin Klee, David Wai Fung Ma
Filed: 21 Dec 21
Utility
Compositions for Improving Cell Viability and Methods of Use Thereof
14 Apr 22
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell.
Joshua Cohen, Justin Klee
Filed: 21 Dec 21
Utility
Compositions for improving cell viability and methods of use thereof
27 Jul 21
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell.
Joshua Cohen, Justin Klee
Filed: 20 Feb 19
Utility
Methods and Compositions for Treating Various Disorders
24 Jun 21
Provided herein are methods and compositions for treating at least one symptom of ALS, slowing ALS di,sease progression, or reducing the deterioration of one or more bodily functions affected by ALS in a subject.
Joshua Cohen, Justin Klee
Filed: 28 Aug 20
Utility
Compositions of Bile Acids and Phenylbutyrate Compounds
17 Jun 21
The present disclosure relates to compositions including a phenylbutyrate compound and a bile acid, and methods of processing such compositions.
Joshua Cohen, Justin Klee, David Wai Fung Ma
Filed: 27 Jul 20
Utility
Compositions for improving cell viability and methods of use thereof
7 Dec 20
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell.
Joshua Cohen, Justin Klee
Filed: 3 Feb 20
Utility
Compositions for Improving Cell Viability and Methods of Use Thereof
22 Jul 20
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell.
Joshua Cohen, Justin Klee
Filed: 1 Apr 20
Utility
Compositions for Improving Cell Viability and Methods of Use Thereof
3 Jun 20
This invention relates to methods and compositions for use improving cell viability, particularly neural cell viability, and more particularly to methods and compositions for use improving cell viability by reducing reactive oxygen metabolite-mediated oxidative damage in a cell, regulating redox homeostasis in a cell, or reducing mitochondrial dysfunction in a cell.
Joshua Cohen, Justin Klee
Filed: 3 Feb 20
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