9 patents
Utility
Formulations for Protein Therapeutics
28 Sep 23
Described herein are compositions comprising protein therapeutics, including multispecific polypeptides and fusion proteins, for intravenous administration.
Jonathan CLAPPER, David BIENVENUE, Scott STROMATT, Catherine J. MCMAHAN
Filed: 13 Jan 21
Utility
Methods and Compositions for Preventing Adsorption of Therapeutic Proteins to Drug Delivery System Components
18 May 23
The disclosure provides compositions and methods that reduce protein loss during drug delivery due to adsorption of the protein onto one or more components of a drug delivery system.
Jonathan CLAPPER, Siowfong WEE, Gang LI
Filed: 13 Jan 21
Utility
CD123 Binding Proteins and Related Compositions and Methods
17 Nov 22
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain.
Gabriela HERNANDEZ-HOYOS, Elaine T. SEWELL, Catherine J. MCMAHAN, David BIENVENUE, John W. BLANKENSHIP, Danielle MITCHELL, Peter PAVLIK
Filed: 21 Dec 21
Utility
4-1BB and OX40 Binding Proteins and Related Compositions and Methods, Antibodies Against 4-1BB, Antibodies Against OX40
4 Aug 22
The present disclosure provides antibodies that specifically bind to 4-1BB and/or OX40, including bispecific antibodies that bind to 4-1BB and OX40, and compositions comprising such antibodies.
David Leonard BIENVENUE, Gabriela HERNANDEZ-HOYOS, Lynda MISHER, Danielle Marie MITCHELL, Michelle Hase NELSON, Peter PAVLIK
Filed: 12 Aug 20
Utility
Prostate-specific Membrane Antigen Binding Proteins and Related Compositions and Methods
1 Apr 21
The present invention relates to mono-specific and multi-specific polypeptide therapeutics that specifically target cells expressing prostate-specific membrane antigen (PSMA) and are useful for the treatment of prostate cancer (e.g., castrate-resistant prostate cancer), tumor-related angiogenesis or benign prostatic hyperplasia (BPH).
John W. BLANKENSHIP, Elaine Todd SEWELL, Philip TAN
Filed: 11 May 20
Utility
Single-chain Multivalent Binding Proteins with Effector Function
11 Nov 20
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.
Peter Armstrong THOMPSON, Jeffrey A. LEDBETTER, Martha Susan HAYDEN-LEDBETTER, Laura Sue GROSMAIRE, Robert BADER, William BRADY
Filed: 22 Dec 19
Utility
Antigen Binding Proteins Binding to 5T4 and 4-1BB and Related Compositions and Methods
15 Jul 20
The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB.
David Bienvenue, Gabriela Hernandez-Hoyos, Lynda Misher, Danielle Mitchell, Peter Ellmark, Anna Sall, Christina Furebring, Laura von Schantz, Sara Fritzell, Laura Varas
Filed: 19 Jul 18
Utility
CD123 Binding Proteins and Related Compositions and Methods
27 May 20
The present disclosure relates to protein molecules that specifically bind to CD123, which may have at least one humanized or human CD123-binding domain.
Gabriela Hernandez-Hoyos, Elaine T. Sewell, Catherine J. McMahan, David Bienvenue, John W. Blankenship, Danielle Mitchell, Peter Pavlik
Filed: 20 Sep 17
Utility
Oncofetal Antigen Binding Proteins and Related Compositions and Methods
18 Dec 19
The present disclosure relates to protein molecules that specifically bind to 5T4 and/or 4-1BB.
David Bienvenue, Gabriela Hernandez-Hoyos, Lynda Misher, Danielle Mitchell, Peter Ellmark, Anna Sall, Christina Furebring, Laura von Schantz, Sara Fritzell, Laura Varas
Filed: 20 Feb 19
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