71 patents
Page 2 of 4
Design
Medicament delivery device
21 Jun 22
Christopher Gregory, Geoffrey Jenkins, Matthew Johnson
Filed: 1 Jul 20
Utility
Time Delay Mechanism for a Hydraulic Drug Delivery Device
26 May 22
A medicament delivery device may comprise a medicament chamber configured to hold a medicament, a plunger configured to move relative to the medicament chamber to expel the medicament from the medicament chamber, a pin configured to move from a first pin position wherein the pin prevents movement of the plunger to a second pin position wherein the pin allows movement of the plunger, an actuation assembly configured to move the pin from the first pin position to the second pin position, and a needle coupled to the medicament chamber.
Christopher Gregory, Geoffrey Jenkins
Filed: 11 Feb 22
Utility
Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease
10 May 22
The use of gap junction intercellular communication (GJIC) modulators in the treatment or prevention of diabetic eye disease is disclosed, and more particularly to their use for the treatment or prevention of early stage diabetic retinopathy and diabetic macular edema by inhibiting apoptosis of retinal endothelial cells and inhibiting pericyte loss.
Bjarne Due Larsen, Ulrik Mouritzen, Dongjoon Kim, Sayon Roy
Filed: 4 May 18
Utility
KV1.3 blockers
5 Apr 22
The present invention provides novel blockers of the potassium channel Kv1.3, polynucleotides encoding them, and methods of making and using them.
Henrik Fischer Munch, Rasmus Bugge Jensen, Jens Kvist Madsen
Filed: 23 Jun 21
Utility
Homodetic cyclic peptides targeting alpha-4-beta-7 integrin
29 Mar 22
There is described herein antagonists of α4β7 integrin, and more particularly cyclic peptide antagonists, such as compounds of formula (I).
Manuel Perez Vazquez, M. Monzur Morshed, Adam Paul Kafal, Jennifer L. Hickey, Andrew Roughton
Filed: 10 May 18
Utility
Time delay mechanism for a hydraulic drug delivery device
22 Mar 22
A medicament delivery device may comprise a medicament chamber configured to hold a medicament, a plunger configured to move relative to the medicament chamber to expel the medicament from the medicament chamber, a pin configured to move from a first pin position wherein the pin prevents movement of the plunger to a second pin position wherein the pin allows movement of the plunger, an actuation assembly configured to move the pin from the first pin position to the second pin position, and a needle coupled to the medicament chamber.
Christopher Gregory, Geoffrey Jenkins
Filed: 20 Jun 18
Utility
Acylated glucagon analogue
15 Mar 22
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders.
Ditte Riber, Jakob Lind Tolborg, Dieter Wolfgang Hamprecht, Leo Thomas
Filed: 13 May 19
Utility
Acylated Glucagon Analogues
10 Mar 22
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders.
Ditte RIBER, Jakob Lind TOLBORG, Dieter Wolfgang HAMPRECHT, Wolfgang RIST
Filed: 7 Jul 21
Utility
Gip Agonist Compounds and Methods
10 Feb 22
The present invention relates to acylated GIP analogues which have GIP agonist activity, and their use in the treatment of metabolic disorders.
Anne Pernille Tofteng SHELTON, Pia NØRREGAARD, Maria Alexandrovna DERYABINA, Bjarne Due LARSEN, Jacob Ulrik FOG
Filed: 2 Apr 21
Utility
Formulations of GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) Analogues
3 Feb 22
Liquid formulations of GLP-2 analogues are described that make it possible to include a preservative while allowing the formulation to be stabilised for long term storage as liquids and/or as multi-dose liquid formulations.
Henrik Rajesh Kumar PARSHAD, Lise GIEHM, Claes MELANDER
Filed: 27 Sep 19
Utility
Multi-Cartridge Fluid Delivery Device
20 Jan 22
A fluid delivery device for administering a first medicament and a second medicament includes a first fluid reservoir configured to contain the first medicament and a second fluid reservoir configured to contain the second medicament.
Robert R. GONNELLI, Steven F. LEVESQUE, Ronald V. NARDI
Filed: 1 Oct 21
Utility
KV1.3 Blockers
9 Dec 21
The present invention provides novel blockers of the potassium channel Kv1.3, polynucleotides encoding them, and methods of making and using them.
Henrik Fischer Munch, Rasmus Bugge Jensen, Jens Kvist Madsen
Filed: 23 Jun 21
Utility
GLUCAGON-GLP-1-GIP Triple Agonist Compounds
25 Nov 21
The present invention relates to compounds which have agonist activity at the glucagon, GIP and GLP-1 receptors, and to their use in the treatment of metabolic disorders.
Rasmus JUST, Ditte RIBER, Anne Pernille Tofteng SHELTON, Torben ØSTERLUND, Kate HANSEN, Lene JESSEN
Filed: 29 Jul 21
Utility
Amylin Analogues
11 Nov 21
The present invention relates to amylin analogues and to their use in the treatment or prevention of a variety of diseases, conditions or disorders, including obesity, excess food intake and associated metabolic diseases such as diabetes.
Jesper Mosolff MATHIESEN, Jesper Skodborg VILLADSEN, Lise GIEHM, Henrik Kofoed MUNCH, Dieter Wolfgang HAMPRECHT, Alexander HEIM-RIETHER, Giacomo FOSSATI
Filed: 21 Jul 21
Design
Medicament delivery device
9 Nov 21
Christopher Gregory, Geoffrey Jenkins, Matthew Johnson
Filed: 25 Feb 21
Utility
Cyclic Peptides Multimers Targeting ALPHA-4-BETA-7 Integrin
21 Oct 21
Mohammed Monzur MORSHED, Sai Kumar CHAKKA, Jennifer L. HICKEY, Manuel Perez VAZQUEZ, Andrew ROUGHTON, Adam Paul KAFAL, Narendrakumar B. PATEL
Filed: 19 Apr 21
Utility
GLUCAGON-LIKE-PEPTIDE-2 (GLP-2) Analogues
7 Oct 21
GLP-2 analogues are disclosed which comprise one of more substitutions as compared to [hGly2]GLP-2 and which improved biological activity in vivo and/or improved chemical stability, e.g., as assessed in in vitro stability assays.
Bjarne Due LARSEN, Yvette Miata PETERSEN
Filed: 21 Jan 21
Utility
Cyclic Peptides Targeting ALPHA-4-BETA-7 Integrin
30 Sep 21
Manuel Perez VAZQUEZ, M. Monzur MORSHED, Jennifer L. HICKEY, Adam Paul KAFAL, James GILLARD, Narendra PATEL, Sai Kumar CHAKKA, Andrew L. ROUGHTON, Marc-André POUPART, Gaoqiang YANG
Filed: 26 Mar 21
Utility
GLP-1/GLP-2 dual agonists
28 Sep 21
The invention relates to compounds having agonist activity at the GLP-1 (glucagon-like-peptide 1) and GLP-2 (glucagon-like peptide 2) receptors.
Bjarne Due Larsen, Lise Giehm, Alistair Vincent Gordon Edwards
Filed: 11 Dec 17
Utility
Liquid Formulations of Glucagon Analogues
16 Sep 21
The present invention relates to formulations of glucagon analogues, or a pharmaceutically acceptable salt thereof and/or a derivative thereof; and their medical use, for example in the treatment of hypoglycaemia.
Jesper Skodborg VILLADSEN, Tine Elisabeth Gottschalk BØVING
Filed: 16 Mar 21