19 patents
Utility
Cyclized Acetamido Derivatives As Dna Polymerase Theta Inhibitors
28 Sep 23
Hilary Plake BECK, Michael Patrick DILLON, Brian Thomas JONES, Luisruben Padilla MARTINEZ
Filed: 28 Jul 21
Utility
Piperazine Substituted Indazole Compounds As Inhibitors of Parg
28 Sep 23
Paul A. BARSANTI, Michael Patrick DILLON, Firoz Ali JAIPURI, Ying-Zi XU, Xin LINGHU, Monah ABED
Filed: 22 Mar 23
Utility
4-ARYLQUINAZOLINE Derivatives As Methionine Adenosyltransferase 2A Inhibitors
17 Aug 23
Leah CLEARY, Melissa FLEURY, Zhonghua PEI, Richard STEEL
Filed: 9 Jun 21
Utility
2-AMINOQUINAZOLINONE Derivatives As Methionine Adenosyltransferase 2A Inhibitors
17 Aug 23
Richard STEEL, Melissa FLEURY, Paul A. BARSANTI
Filed: 9 Jun 21
Utility
Quinolinone Derivatives As Methionine Adenosyltransferase 2A Inhibitors
20 Jul 23
Leah CLEARY, Melissa FLEURY, Zhonghua PEI
Filed: 9 Jun 21
Utility
Thiadiazolyl Derivatives
16 Mar 23
Paul A. BARSANTI, Hilary Plake BECK, Melissa FLEURY, John E. KNOX, Ethan DeNardo MCSPADDEN, Brian Thomas JONES, Luisruben P. MARTINEZ, Zhonghua PEI, Chenbo WANG
Filed: 29 May 20
Utility
AhR MODULATORS
9 Feb 23
Muzaffar ALAM, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, James Clifford SUTTON, JR.
Filed: 29 Jun 22
Utility
Dosing Regimens for a Protein Kinase C Inhibitor
22 Dec 22
Disclosed herein are dosing regimens for the treatment of cancer mediated by protein kinase C (PKC) with 3-amino-N-(3-(4-amino-4-methylpiperidin-1-yl)pyridin-2-yl)-6-(3-(trifluoromethyl)pyridin-2-yl)pyrazine-2-carboxamide, Compound (I), or a pharmaceutically acceptable salt thereof.
Julie Hambleton, Jianhong Wang
Filed: 18 Nov 20
Utility
4-SUBSTITUTED Indole and Indazole Sulfonamido Derivatives As Parg Inhibitors
8 Dec 22
James Clifford SUTTON, Jr., Michael Patrick Dillon
Filed: 18 Sep 20
Utility
Methods of Culturing And/or Expanding Stem Cells And/or Lineage Committed Progenitor Cells Using Amido Compounds
27 Oct 22
Muzaffar ALAM, Fred ASWAD, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, Yujiro HATA, Alice Chen RICO, James Clifford SUTTON, Jr.
Filed: 18 Jul 19
Utility
Treatment of Cancer Having Gnaq or GNA11 Genetic Mutations with Protein Kinase C Inhibitors
29 Sep 22
The present disclosure relates in part to methods for treating non-uveal melanoma cancers having GNAQ or GNA11 genetic mutations that include administering a PKC small molecule inhibitor.
John Knox, Mark Lackner, Zineb Mounir, Carol O'Brien
Filed: 7 Jan 20
Utility
DIHYDROTHIENO[3,2-b]PYRIDINE COMPOUNDS
21 Jul 22
Hilary Plake BECK, Leah Brigit CLEARY, Michael Patrick DILLON, Marcos GONZALES-LOPEZ, Luis Ruben P. MARTINEZ, James Clifford SUTTON
Filed: 25 Sep 18
Utility
Acetamido Derivatives As Dna Polymerase Theta Inhibitors
31 Mar 22
Hilary Plake BECK, Michael DILLON, Brian JONES, Luisruben P. MARTINEZ, Zhonghua PEI
Filed: 29 Jan 20
Utility
Heteroarylmethylene Derivatives As Dna Polymerase Theta Inhibitors
16 Dec 21
Hilary Plake BECK, Michael DILLON, Brian JONES, Luisruben P. MARTINEZ
Filed: 30 Jan 20
Utility
Methods of Inhibiting Proliferative Cells
2 Dec 21
The present invention provides methods of negatively modulating the Werner protein (WRN) to inhibit proliferative cells characterized by high microsatellite instability (MSI-H), for example to treat proliferative diseases (such as cancer) characterized by high MSI (MSI-H).
Lisa BELMONT, Jeff HAGER, Yujiro HATA, Lorn KATEGAYA
Filed: 17 Jun 19
Utility
Methods of Culturing And/or Expanding Stem Cells And/or Lineage Committed Progenitor Cells Using Lactam Compounds
19 Aug 21
Muzaffar ALAM, Fred ASWAD, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, Yujiro HATA, James Clifford SUTTON, Jr.
Filed: 5 Jun 19
Utility
AMIDO COMPOUNDS AS AhR MODULATORS
22 Apr 21
Muzaffar ALAM, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, Alice Chen RICO, James Clifford SUTTON, Jr.
Filed: 18 Jul 18
Utility
Compounds and Methods for the Modulation of Ahr
18 Mar 21
Hilary Plake BECK, Marcos GONZALEZ-LOPEZ, James Clifford SUTTON, JR.
Filed: 5 Feb 19
Utility
AhR MODULATORS
6 Jan 21
Muzaffar ALAM, Hilary Plake BECK, Michael Patrick DILLON, Marcos GONZALEZ-LOPEZ, James Clifford SUTTON, JR.
Filed: 16 Sep 20
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