44 patents
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
18 Jan 24
Jincong Zhuo, Andrew Combs
Filed: 8 Mar 23
Utility
BRM Targeting Compounds and Associated Methods of Use
18 Jan 24
The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.
Hong Lin, Philip Pitis, Liang Lu, Andrew Paul Combs
Filed: 15 May 23
Utility
KAT6 Targeting Compounds
28 Dec 23
The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.
Sarah Pawley, Andrew Buesking, Andrew Combs
Filed: 16 Jun 23
Utility
BRM Targeting Compounds And Associated Methods Of Use
16 Nov 23
John A. Rose, Corey Howard Basch, Song Mei, Klare Lazor Bersh, Danielle Roth, Katarina Rohlfing, Xiaowei Wu, Artem Shvartsbart, Andrew Paul Combs, Liang Lu
Filed: 9 May 23
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
9 Nov 23
Andrew W. Buesking, Andrew Paul Combs, Jincong Zhou, Ryan Holmes, Sarah Pawley, Xiaowei Wu
Filed: 16 Mar 23
Utility
Spiro-sulfonamide Derivatives As Inhibitors of Myeloid Cell LEUKEMIA-1 (MCL-1) Protein
9 Nov 23
Jincong Zhuo, Ganfeng Cao, Andrew Paul Combs, Qun Li, Huaping Zhang
Filed: 13 May 21
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
17 Aug 23
Jincong ZHUO, Xiaowei Wu, Katarina Rohlfing, Andrew Combs
Filed: 2 Feb 23
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
3 Aug 23
The disclosure is directed to, in part, to CDK inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.
Liang Lu, Rupa Shetty, Andrew Paul Combs, Chaofeng Dai, Raul Andrew Leal, Klare Lazor Bersch
Filed: 4 Apr 23
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
27 Jul 23
Jincong Zhuo, Xiaowei Wu, Katarina Rohlfing, Andrew Combs
Filed: 20 Jan 23
Utility
BRM targeting compounds and associated methods of use
18 Jul 23
The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.
Hong Lin, Philip Pitis, Liang Lu, Andrew Paul Combs
Filed: 9 Jun 21
Utility
Spiro-sulfonimidamide Derivatives As Inhibitors of Myeloid Cell LEUKEMIA-1 (MCL-1) Protein
6 Jul 23
Jincong ZHUO, Andrew Paul COMBS
Filed: 16 Apr 21
Utility
CDK inhibitors and their use as pharmaceuticals
27 Jun 23
Andrew W. Buesking, Andrew Paul Combs, Jincong Zhuo, Ryan Holmes, Sarah Pawley, Xiaowei Wu
Filed: 21 Sep 21
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
11 May 23
The disclosure is directed to, in part, to CDK inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.
Liang Lu, Rupa Shetty, Andrew Paul Combs, Chaofeng Dai, Raul Andrew Leal, Klare Lazor Bersch
Filed: 30 Sep 22
Utility
BCL-2 inhibitors and their use as pharmaceuticals
11 Apr 23
The disclosure is directed to, in part, to BCL-2 inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.
Jincong Zhuo, Andrew Paul Combs, Peng Wei, Jialiang Wang
Filed: 27 Apr 21
Utility
BRM Targeting Compounds And Associated Methods Of Use
16 Mar 23
The present disclosure provides bifunctional compounds comprising a target protein binding moiety and a E3 ubiquitin ligase binding moiety, and associated methods of use.
Liang Lu, Andrew Paul Combs, Corey Howard Basch, Rupa Shetty, Chaofeng Dai, Klare Lazor Bersch, John A. Rose, Danielle Julie Beam, Song Mei
Filed: 8 Nov 21
Utility
Selective Inhibitors Of Protein Arginine Methyltransferase 5 (PRMT5)
26 Jan 23
Ganfeng Cao, Qun Li, Huaping Zhang, Hongwu Yu
Filed: 18 Sep 20
Utility
Spiro-Sulfonamide Derivatives As Inhibitors Of Myeloid Cell Leukemia-1 (MCL-1) Protein
12 Jan 23
Jincong Zhuo, Raul Leal, Rupa Shetty, Juan Luengo, Andrew Paul Combs, Peng Wei
Filed: 17 Aug 21
Utility
Substituted pyrrolo[2,3-d]pyrimidines as inhibitors of protein arginine methyl transferase 5 (PRMT5)
13 Dec 22
Juan Luengo, Hong Lin, Michael Hawkins
Filed: 26 Oct 18
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
13 Oct 22
The disclosure is directed to, in part, to CDK inhibitors, pharmaceutical compositions comprising the same, as well as methods of their use and preparation.
Liang Lu, Rupa Shetty, Andrew Paul Combs, Chaofeng Dai, Raul Andrew Leal, Klare Lazor Bersch
Filed: 11 Sep 20
Utility
CDK Inhibitors And Their Use As Pharmaceuticals
25 Aug 22
Xiaowei Wu, Andrew W. Buesking, Andrew Paul Combs, Ryan Holmes, Sarah Pawley, Katarina Rohlfing
Filed: 17 Dec 21