14 patents
Utility
Compositions and methods for modulating FMR1 expression
21 Nov 23
The disclosure relates to methods and compositions for reactivating a silenced FMR1 gene.
Michael R. Green, Minggang Fang, Walter Kowtoniuk
Filed: 16 Sep 16
Utility
Use of P38 Inhibitors to Reduce Expression of DUX4
17 Aug 23
The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4.
Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, III, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
Filed: 20 Sep 22
Utility
Macrocyclic azolopyridine derivatives as EED and PRC2 modulators
28 Feb 23
Ivan Viktorovich Efremov, Steven Kazmirski, Qingyi Li, Lorin A. Thompson, III, Owen Brendan Wallace, Shawn Donald Johnstone, Feng Zhou, Peter Rahl
Filed: 18 Feb 21
Utility
Use of p38 inhibitors to reduce expression of DUX4
25 Oct 22
The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4.
Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, III, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
Filed: 5 Oct 18
Utility
P38 Kinase Inhibitors Reduce DUX4 and Downstream Gene Expression for the Treatment of FSHD
8 Sep 22
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A.
Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, Iii, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
Filed: 11 May 22
Utility
Macrocyclic Azolopyridine Derivatives As Eed and PRC2 Modulators
26 May 22
Ivan Viktorovich Efremov, Steven Kazmirski, Qingyi Li, Lorin A. Thompson, III, Owen Brendan Wallace, Shawn Donald Johnstone, Feng Zhou, Peter Rahl
Filed: 18 Feb 21
Utility
P38 Kinase Inhibitors Reduce DUX4 and Downstream Gene Expression for the Treatment of FSHD
5 May 22
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A.
Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, III, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
Filed: 12 Nov 21
Utility
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
5 Apr 22
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A.
Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, III, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
Filed: 21 Jan 20
Utility
Compositions and Methods for Increasing Fetal Hemoglobin and Treating Sickle Cell Disease
20 Jan 22
The present invention relates to compositions and methods of increasing levels of fetal hemoglobin (HbF) in cells.
Peter Rahl, Angela Marie Cacace, Michael Cameron, Akshay Kakumanu
Filed: 20 Nov 19
Utility
Macrocyclic azolopyridine derivatives as EED and PRC2 modulators
13 Apr 21
Ivan Viktorovich Efremov, Steven Kazmirski, Qingyi Li, Lorin A. Thompson, III, Owen Brendan Wallace, Shawn Donald Johnstone, Feng Zhou, Peter Rahl
Filed: 24 Apr 20
Utility
P38 Kinase Inhibitors Reduce DUX4 and Downstream Gene Expression for the Treatment of FSHD
9 Dec 20
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, orZNF280A.
Angela Marie CACACE, Luis Gustavo Alejandro ROJAS SOTO, Lorin A. THOMPSON, III, Owen Brendan WALLACE, Lucienne V. RONCO, Ning SHEN, Alan Scott ROBERTSON, Aaron Nakwon CHANG
Filed: 20 Jan 20
Utility
Macrocyclic Azolopyridine Derivatives As Eed and PRC2 Modulators
18 Nov 20
Ivan Viktorovich EFREMOV, Steven KAZMIRSKI, Qingyi LI, Lorin A. THOMPSON, III, Owen Brendan WALLACE, Shawn Donald JOHNSTONE, Feng ZHOU, Peter RAHL
Filed: 23 Apr 20
Utility
Use of P38 Inhibitors to Reduce Expression of DUX4
21 Oct 20
The present invention relates to compositions and methods of inhibiting p38 kinase to reduce gene and protein expression of DUX4 and downstream genes regulated by DUX4.
Angela Marie CACACE, Luis Gustavo Alejandro ROJAS SOTO, Lorin A. THOMPSON, III, Owen Brendan WALLACE, Lucienne V. RONCO, Ning SHEN, Alan Scott ROBERTSON, Aaron Nakwon CHANG
Filed: 4 Oct 18
Utility
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
20 Jan 20
The disclosure relates to methods and compositions including p38 kinase inhibitors and agents that regulate expression of DUX4 and downstream genes including but not restricted to ZSCAN4, LEUTX, PRAMEF2, TRIM43, MBD3L2, KHDC1L, RFPL2, CCNA1, SLC34A2, TPRX1, PRAMEF20, TRIM49, PRAMEF4, PRAME6, PRAMEF15, or ZNF280A.
Angela Marie Cacace, Luis Gustavo Alejandro Rojas Soto, Lorin A. Thompson, III, Owen Brendan Wallace, Lucienne V. Ronco, Ning Shen, Alan Scott Robertson, Aaron Nakwon Chang
Filed: 18 Nov 18
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