78 patents
Page 3 of 4
Utility
Treatment of Skin Disorders with Topical Roflumilast Combination Compositions
5 Aug 21
Moshe ARKIN, Marcel ZIGHELBOIM, Karine NEIMANN
Filed: 3 Feb 21
Utility
Compositions Comprising Roflumilast for Treating Hidradenitis Suppurativa and Prurigo Nodularis
5 Aug 21
Moshe Arkin, Marcel Zighelboim, Karine Neimann, Hila Hakak Djerbi
Filed: 3 Feb 21
Utility
Core stabilized microcapsules, method of their preparation and uses thereof
27 Jul 21
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
Filed: 19 Mar 18
Utility
Methods and Compositions for the Treatment of Granuloma Annulare or Subcutaneous Inflammation and Non-infection Granulomatous Diseases
15 Jul 21
The present invention, in some embodiments thereof, relates to topical compositions and methods of treatment, prevention and/or amelioration of granuloma annulare, a non-infection granulomatous disease, or a subcutaneous inflammation by topical or intralesional administration of compositions comprising tapinarof.
Marcel Zighelboim, Hila Hakak Djerbi, Karine Neimann
Filed: 13 Jan 21
Utility
Method for Treatment of Rosacea In Patients Aged 65 Years and Older
10 Jun 21
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 21 Jan 21
Utility
Method for Providing Early Onset of Action In the Treatment of Rosacea
20 May 21
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer TOLEDANO, Ofra LEVY-HACHAM, Ori NOV, Vered RAM
Filed: 25 Jan 21
Utility
Methods and Compositions for the Treatment of Acne
22 Apr 21
The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.
Ofer Toledano, Ofra Levy-Hacham, Rinat Mizrahi
Filed: 30 Dec 20
Utility
Process for the preparation of glycopyrrolate tosylate
23 Mar 21
The present application provides novel process for the preparation of glycopyrrolate tosylate.
Stephen Cherkez, Veera Reddy Arava, Madhusudhanarao Rayapureddi, Venkateswarlu Jasti
Filed: 12 Mar 18
Utility
Method for providing early onset of action in the treatment of rosacea
16 Mar 21
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
Utility
Process for the preparation of glycopyrrolate tosylate
16 Mar 21
This invention is directed to a process for the preparation of glycopyrrolate tosylate comprising the step of reacting a halogen salt of glycopyrrolate with tosylic acid or a salt thereof in the presence of hydrogen peroxide and at least one unsaturated organic agent.
Veera Reddy Arava, Madhusudhanarao Rayapureddi, Venkateswarlu Jasti
Filed: 26 Jul 18
Utility
Method for treatment of rosacea in patients aged 65 years and older
2 Mar 21
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
Utility
Method for Preparing Particles Comprising Metal Oxide Coating and Particles with Metal Oxide Coating
14 Jan 21
The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer.
Ofer TOLEDANO, Haim Bar-Simantov, Nissim Bilman, Leora Shapiro, Raed Abu-Reziq, Hanan Sertchook
Filed: 10 Sep 20
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
6 Jan 21
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 14 Jul 20
Utility
Pharmaceutical Compositions Comprising Silica Microspheres
6 Jan 21
Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof.
MARINA SHEVACHMAN, AMIRA ZE' EVI, EILON ASCULAI, BATELLA BENYAMINOVICH, NIR AVRAM, CHAIM ASCHKENASY
Filed: 16 Sep 20
Utility
Methods for the Treatment of Rosacea
30 Dec 20
The present invention relates to pharmaceutical compositions for topical use (including also dermatological compositions), for treating skin conditions and afflictions, such as rosacea and symptoms and conditions associated there from.
Hanan SERTCHOOK, Ofer Toledano, Haim Bar-Simantov
Filed: 9 Sep 20
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
16 Dec 20
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 21 Jul 20
Utility
Treatment of Ocular Diseases with Ophthalmic Tapinarof Compositions
16 Dec 20
The present invention relates to the treatment of an ocular inflammatory disease or an ocular degeneration disease by ophthalmic administration of a composition comprising tapinarof and optionally at least one additional active agent.
Moshe ARKIN, Marcel ZIGHELBOIM
Filed: 16 Aug 20
Utility
Method for Preparing Particles Comprising Metal Oxide Coating and Particles with Metal Oxide Coating
9 Dec 20
The invention relates to a process for coating a solid, water-insoluble particulate matter, with a metal oxide comprising: (a) contacting the solid, water-insoluble particulate matter with an ionic additive and an aqueous medium to obtain a dispersion of said particulate matter having positive charges on its surface; (b) subjecting the particulate matter to a coating procedure comprising precipitating a metal oxide salt onto the surface of the particulate matter to form a metal oxide layer thereon to thereby obtain particulate matter coated by a metal oxide coating layer; (c) repeating step (b) at least 4 more times; and (d) aging said coating layer.
Ofer TOLEDANO, Haim BAR-SIMANTOV, Nissim BILMAN, Leora SHAPIRO, Raed ABU-REZIQ, Hanan SERTCHOOK
Filed: 24 Aug 20
Utility
Process for the Preparation of Glycopyrrolate Tosylate
2 Dec 20
The present application provides novel process for the preparation of glycopyrrolate tosylate.
Stephen CHERKEZ, Veera Reddy ARAVA, Madhusudhanarao RAYAPUREDDI, Venkateswarlu JASTI
Filed: 11 Mar 18
Utility
Process for the Preparation of Glycopyrrolate Tosylate
2 Dec 20
This invention is directed to a process for the preparation of glycopyrrolate tosylate comprising the step of reacting a halogen salt of glycopyrrolate with tosylic acid or a salt thereof in the presence of hydrogen peroxide and at least one unsaturated organic agent.
Veera Reddy ARAVA, Madhusudhanarao RAYAPUREDDI, Venkateswarlu JASTI
Filed: 25 Jul 18