17 patents
Utility
Method for treatment of rosacea in patients aged 65 years and older
9 Jan 24
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 21 Jan 21
Utility
Pharmaceutical compositions comprising silica microspheres
9 Jan 24
Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof.
Marina Shevachman, Amira Ze' Evi, Eilon Asculai, Batella Benyaminovich, Nir Avram, Chaim Aschkenasy
Filed: 17 Sep 20
Utility
Treatment of skin disorders with compositions comprising an EGFR inhibitor
25 Apr 23
This invention relates to compositions and methods of treatment of skin or mucosal disorders by administration of compositions comprising at least one EGFR inhibitor, such as topical compositions comprising erlotinib.
Moshe Arkin, Marcel Zighelboim, Ori Nov, Ofer Toledano, Karine Neimann
Filed: 8 Jan 20
Utility
Method for therapeutic treatment of rosacea
18 Apr 23
A regimen and a pharmaceutical composition for the treatment of rosacea are described.
Ofer Toledano, Ori Nov
Filed: 19 Feb 20
Utility
Method for treatment of rosacea
3 Jan 23
A regimen is described for the therapeutic treatment of rosacea.
Moshe Arkin, Karine Neimann, Ofer Toledano
Filed: 3 Dec 21
Utility
Method for long-term treatment of rosacea
30 Aug 22
A regimen for the long-term therapeutic treatment of rosacea.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
Utility
Core stabilized microcapsules, method of their preparation and uses thereof
27 Jul 21
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
Filed: 19 Mar 18
Utility
Process for the preparation of glycopyrrolate tosylate
23 Mar 21
The present application provides novel process for the preparation of glycopyrrolate tosylate.
Stephen Cherkez, Veera Reddy Arava, Madhusudhanarao Rayapureddi, Venkateswarlu Jasti
Filed: 12 Mar 18
Utility
Method for providing early onset of action in the treatment of rosacea
16 Mar 21
A regimen is described for providing early onset of action in the therapeutic treatment of rosacea including topically applying a pharmaceutical composition to the skin of a subject in need of said treatment.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
Utility
Process for the preparation of glycopyrrolate tosylate
16 Mar 21
This invention is directed to a process for the preparation of glycopyrrolate tosylate comprising the step of reacting a halogen salt of glycopyrrolate with tosylic acid or a salt thereof in the presence of hydrogen peroxide and at least one unsaturated organic agent.
Veera Reddy Arava, Madhusudhanarao Rayapureddi, Venkateswarlu Jasti
Filed: 26 Jul 18
Utility
Method for treatment of rosacea in patients aged 65 years and older
2 Mar 21
A regimen for the therapeutic treatment of rosacea in subjects aged 65 years and older, the regimen comprising topically applying to the skin of a subject aged 65 years and older in need of said treatment a pharmaceutical composition, the pharmaceutical composition comprising about 1% w/w to about 10% w/w benzoyl peroxide as an active ingredient, and a pharmaceutically acceptable carrier or excipient, wherein the benzoyl peroxide is the only active ingredient in said pharmaceutical composition, wherein said pharmaceutical composition is applied once daily for a period of at least about 2 weeks, to achieve, in a group of such subjects, a success rate of at least about 15%, wherein the success rate is defined as the number of subjects achieving clear or almost clear skin on the investor global assessment (IGA) scale after treatment with the pharmaceutical composition.
Ofer Toledano, Ofra Levy-Hacham, Ori Nov, Vered Ram
Filed: 19 Feb 20
Utility
Pharmaceutical compositions comprising silica microspheres
21 Sep 20
Topical vaginal compositions are disclosed herein which include silica microspheres and an active ingredient in the amount of 0.001 to 15.0% w/w selected from estradiol, metronidazole, clindamycin, butoconazole, and combinations thereof.
Marina Shevachman, Amira Ze'Evi, Eilon Asculai, Batella Binyaminovich, Nir Avram, Chaim Aschkenasy
Filed: 16 Apr 19
Utility
Methods and compositions for the treatment of acne
6 Jul 20
The present application is directed to regimens, methods of treatment, and compositions for the treatment of acne in a subject suffering therefrom.
Ofer Toledano, Ori Nov
Filed: 16 Jul 19
Utility
Microcapsules comprising active ingredients and a metal oxide shell, a method for their preparation and uses thereof
22 Jun 20
The present invention provides a process for preparing microcapsules comprising a core material encapsulated by a metal oxide shell, microcapsules obtained therewith and uses thereof.
Ofer Toledano, Hanan Sertchook, Natalia Loboda, Raed Abu-Reziq
Filed: 1 Aug 09
Utility
Core stabilized microcapsules, method of their preparation and uses thereof
18 May 20
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within an inorganic oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco
Filed: 1 Aug 18
Utility
Formation of nanometric core-shell particles having a metal oxide shell
6 Jan 20
Ofer Toledano, Hanan Sertchook, Raed Abu-Reziq, Haim Bar-Simantov, Leora Shapiro
Filed: 11 Dec 07
Utility
Core stabilized microcapsules, method of their preparation and uses thereof
23 Dec 19
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
Ofer Toledano, Haim Bar-Simantov, Hanan Sertchook, Sharon Fireman-Shoresh, Dorit Marco-Dagan
Filed: 29 Dec 10
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