56 patents
Utility
Dosing Regimens for the Mobilization of Hematopoietic Stem Cells
27 Apr 23
Described herein are compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a subject, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use.
Dwight Morrow, Patrick C. Falahee, Anthony Boitano, Michael P. Cooke, Kevin A. Goncalves
Filed: 12 May 22
Utility
Novel Linkers for Antibody-drug Conjugates and Related Compounds, Compositions, and Methods of Use
6 Apr 23
Provided herein are antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers
David Y. Jackson, Edward Ha
Filed: 8 Dec 21
Utility
Anti-CD117 antibodies and conjugates
7 Feb 23
The invention provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, and autoimmune diseases, among others.
Bradley R. Pearse, Anthony Boitano, Rahul Palchaudhuri, Sean McDonough, Rajiv Panwar, Jonathan Philip Belk, Matthew Duncan Smith
Filed: 17 Nov 20
Utility
Dosing Regimens for the Mobilization of Hematopoietic Stem and Progenitor Cells
22 Dec 22
The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use.
Anthony Boitano, Michael P. Cooke, John C. Davis, Patrick C. Falahee, Kevin A. Goncalves, Sharon Hyzy, Dwight Morrow, Jason Neale, Glen Raffel, William Savage, Veit Schmelmer
Filed: 30 Oct 20
Utility
Methods and Compositions for Treating Autoimmune Diseases
1 Sep 22
Disclosed are methods and compositions relating to the treatment of autoimmune diseases using anti-CD45 antibody drug conjugates (ADCs).
Geoffrey O. Gillard, Jennifer Lynn Proctor, Anthony Boitano, Michael Cooke
Filed: 3 Dec 21
Utility
ANTI-CD45 Antibodies and Conjugates Thereof
25 Aug 22
Disclosed are anti-CD45 antibodies, antigen binding fragments thereof, and antibody drug conjugates (ADCs) that specifically bind to human CD45.
Anthony Boitano, Michael Cooke, Charlotte Fenton McDonagh, Rahul Palchaudhuri, Rajiv Panwar, Bradley Pearse, Paul Fredrick Widboom, Patricia Ann Cruite
Filed: 22 Oct 21
Utility
T-cell Depleting Therapies
11 Aug 22
Provided herein are methods of depleting T cells for therapeutic uses, including administration of anti-CD2 or anti-CD5 antibody drugs conjugates (ADCs) for treatment.
Anthony Boitano, Michael Cooke, Sean Mcdonough, Jennifer Lynn Proctor
Filed: 3 Dec 21
Utility
Anthracycline Antibody-drug Conjugates and Uses Thereof
21 Jul 22
Antibody-drug conjugates (ADCs) comprising an anthracycline and an anti-CD117 antibody are provided, as well as compositions and methods of using the same.
Charlotte Fenton McDonagh, Anthony Boitano, Michael Cooke, Ganapathy N. Sarma, Rajiv Panwar
Filed: 21 Oct 21
Utility
ANTI-CD117 Antibody Drug Conjugates and Uses Thereof
9 Jun 22
Anti-CD117 antibody-drug conjugates (ADCs) comprising calicheamicin and are provided, as well as compositions and methods of using the same.
Charlotte Fenton McDonagh, Anthony Boitano, Michael Cooke, Ganapathy N. Sarma, Rajiv Panwar
Filed: 22 Oct 21
Utility
ANTI-CD117 Antibodies and Uses Thereof
9 Jun 22
The present disclosure provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others.
Rahul Palchaudhuri, Anthony Boitano, Michael Cooke, Bradley R. Pearse
Filed: 22 Oct 21
Utility
ANTI-CD117 Antibodies and Uses Thereof
9 Jun 22
The present disclosure provides compositions and methods useful for the depletion of CD117+ cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others.
Rahul Palchaudhuri, Anthony Boitano, Michael Cooke, Bradley R. Pearse
Filed: 22 Oct 21
Utility
ANTI-CD117 Antibody-drug Conjugates and Uses Thereof
9 Jun 22
Anti-CD117 antibody-drug conjugates (ADCs) comprising pyrrolobenzodiazepine are provided, as well as compositions and methods of using the same.
Charlotte F. McDonagh, Anthony Boitano, Michael Cooke, Ganapathy N. Sarma, Rajiv Panwar
Filed: 21 Oct 21
Utility
Anti-CD45 Antibody Drug Conjugates and Uses Thereof
9 Jun 22
The invention provides anti-CD45 antibody drug conjugates (ADCs), and methods of use thereof.
Anthony Boitano, Michael Cooke, Geoffrey O. Gillard, Charlotte Fenton McDonagh, Rahul Palchaudhuri, Bradley R. Pearse
Filed: 22 Oct 21
Utility
Conditioning Methods for Gene Therapy
9 Jun 22
The disclosure provides compositions and methods useful for the depletion of a specific population of endogenous hematopoietic stem cells and/or immune cells from a subject prior to transplantation with genetically modified stem cells to improve the engraftment of the transplanted stem cells and provide gene therapy.
Anthony BOITANO, Michael Cooke, Rahul Palchaudhuri, Bradley R. Pearse
Filed: 21 Oct 21
Utility
Dosing Regimens for the Mobilization of Hematopoietic Stem and Progenitor Cells
31 Mar 22
The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use.
Dwight Morrow, Patrick C. Falahee, Anthony Boitano, Michael P. Cooke, Kevin A. Goncalves
Filed: 7 May 21
Utility
Use of an ANTI-CD45 Antibody Drug Conjugate (Adc) In Cell Therapy
3 Mar 22
The invention provides methods of depleting CD45+ cells in human patients undergoing chimeric antigen receptor (CAR) immunotherapy in order to promote acceptance of CAR expressing immune cells.
Michael Cooke, Geoffrey O. Gillard, Anthony Boitano
Filed: 6 Jul 21
Utility
Dosing regimens for the mobilization of hematopoietic stem and progenitor cells
1 Mar 22
The invention provides compositions and methods useful for mobilizing populations of hematopoietic stem and progenitor cells within a donor, as well as for determining whether samples of mobilized cells are suitable for release for ex vivo expansion and/or therapeutic use.
Dwight Morrow, Patrick C. Falahee, Anthony Boitano, Michael P. Cooke, Kevin A. Goncalves
Filed: 13 Mar 19
Utility
Linkers for antibody-drug conjugates and related compounds, compositions, and methods of use
25 Jan 22
Provided herein are antibody-cytotoxin antibody-drug conjugates and related compounds, such as linker-cytotoxin conjugates and the linkers used to make them, and intermediates in their synthesis; compositions; and methods, including methods of treating cancers.
David Y. Jackson, Edward Ha
Filed: 6 Jun 14
Utility
Methods of Treating Cancer with Aryl Hydrocarbon Receptor Antagonists
9 Dec 21
The disclosure relates to aryl hydrocarbon receptor antagonists, such as substituted imidazopyridines and imidazopyrazines, as well as methods of modulating aryl hydrocarbon receptor activity and treating various pathologies, such as cancer, by administration of these aryl hydrocarbon receptor antagonists.
Anthony BOITANO
Filed: 17 Oct 19
Utility
Methods for Hematopoietic Stem and Progenitor Cell Transplant Therapy
9 Dec 21
Provided herein are compositions and methods useful for the transplantation of hematopoietic stem and progenitor cells, as well as for preparing patients for receipt of such therapy, such as patients suffering from a variety of inherited metabolic disorders.
Glen RAFFEL
Filed: 31 Oct 19